期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
组胺调节胃肠功能的机制 被引量:4
1
作者 刘莉洁 杨德治 《南京铁道医学院学报》 2001年第2期134-137,共4页
目前已发现 3种组胺受体 :H1 R、H2 R和H3 R。组胺与细胞膜上相应受体结合 ,可影响细胞膜的离子通透性及细胞内的代谢过程 ,进而调节靶细胞的功能。现就组胺通过 3种组胺受体调节胃肠功能的机制作一综述。
关键词 组胺 受体 离子通 激素 平滑肌 胃粘道
下载PDF
Mucosal Schwann cell “Hamartoma”:A new entity? 被引量:2
2
作者 Paola Pasquini Andrea Baiocchini +4 位作者 Laura Falasca Dante Annibali Guido Gimbo Francesco Pace Franca Del Nonno 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第18期2287-2289,共3页
Schwannoma is a well-described,benign nerve sheath tumor of the soft tissue,but is rare in the gastrointestinal tract.Gastrointestinal schwannomas are often incidentally discovered as small polypoid intraluminal lesio... Schwannoma is a well-described,benign nerve sheath tumor of the soft tissue,but is rare in the gastrointestinal tract.Gastrointestinal schwannomas are often incidentally discovered as small polypoid intraluminal lesions.In this report,we describe the clinicopathologic and immunohistochemical features of a distinctive neural mucosal polyp composed of a diffuse cellular proliferation of uniform bland spindled cells in the lamina propria that entraps the colonic crypts.Immunohistochemical analysis revealed strong and diffuse positivity for the S-100 protein.To avoid confusion of these solitary colorectal polyps containing pure spindled Schwann cell proliferation in the lamina propria with neural lesions that have significant association with inherited syndromes,it is better to use the designation "mucosal Schwann hamartoma". 展开更多
关键词 Nerve sheath tumors Gastrointestinal Schwannoma HAMARTOMA
下载PDF
Progress in researches about focal adhesion kinase in gastrointestinal tract 被引量:8
3
作者 Hui Fang Hao Yoshio Naomoto +9 位作者 Xiao-Hong Bao Nobuyuki Watanabe Kazufumi Sakurama Kazuhiro Noma Yasuko Tomono Takuya Fukazawa Yasuhiro Shirakawa Tomoki Yamatsuji Junji Matsuoka Munenori Takaoka 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第47期5916-5923,共8页
Focal adhesion kinase(FAK)is a 125-kDa non-receptor protein tyrosine.Growth factors or the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in turn recruits Src-family protein ty... Focal adhesion kinase(FAK)is a 125-kDa non-receptor protein tyrosine.Growth factors or the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in turn recruits Src-family protein tyrosine kinases,resulting in the phosphorylation of Tyr-576 and Tyr-577 in the FAK activation loop and full catalytic FAK activation.FAK plays a critical role in the biological processes of normal and cancer cells including the gastrointestinal tract.FAK also plays an important role in the restitution,cell survival and apoptosis and carcinogenesis of the gastrointestinal tract.FAK is over-expressed in cancer cells and its over-expression and elevated activities are associated with motility and invasion of cancer cells.FAK has been proposed as a potential target in cancer therapy.Small molecule inhibitors effectively inhibit the kinase activity of FAK and show a potent inhibitory effect for the proliferation and migration of tumor cells,indicating a high potential for application in cancer therapy. 展开更多
关键词 Focal adhesion kinase RESTITUTION Survival and apoptosis Cancer INHIBITOR
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部