加世纪80年代以前，能性胃肠病（FGID）的研究主要集中在胃肠运动障碍上，胃肠运动障碍病在一定程度上被认为与FGID相同。虽然胃肠动力的研究已超过一个世纪，在临床实践中，胃肠运动障碍性疾病（Disorders of gastrointestinal motilit...加世纪80年代以前，能性胃肠病（FGID）的研究主要集中在胃肠运动障碍上，胃肠运动障碍病在一定程度上被认为与FGID相同。虽然胃肠动力的研究已超过一个世纪，在临床实践中，胃肠运动障碍性疾病（Disorders of gastrointestinal motility）的诊断仍存在问题。过去20年，认识到胃肠运动活动受神经调控，并伴内脏感觉异常，以往医患双方常认为“痉挛”症状是动力异常引起，感知好即动力正常，胃肠道内存在异常感知也可以感到“痉挛痛”。神经胃肠病学的发展，对控制胃肠运动的复杂神经调控机制有了进一步的认识。展开更多
AIM: To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatrnent of gastrointestinal motility diseases.METHODS: Gastrointestinal pro...AIM: To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatrnent of gastrointestinal motility diseases.METHODS: Gastrointestinal propulsion rate was measured by the migration rate of activated charcoal, which reflexes gastrointestinal motility function. 120 Spraque-Dawley rats were randomly divided into four groups and received an intravenous injection of physiological saline (served as control), prucalopdde 1 mg/kg, prucalopride 2 mg/kg and cisapride 1 mg/kg,respectively. The gastrointestinal propulsion rate was measured 1, 2 or 4 hours after intravenous injection of the drugs.RESULTS: Significant accelerations of gastrointestinal propulsion rate in prucalopride 1 mg/kg and 2 mg/kg groups were found compared with control group at 2 and 4 hours (83.2%±5.5%, 81.7%±8.5% vs70.5%±9.2%, P＜0.01;91.2%±2.2%, 91.3%±3.9% vs86.8%±2.6%, P＜0.01).The gastrointestinal propulsion rates at 1, 2 or 4 hours were faster in prucalopride 1 mg/kg and 2 mg/kg groups than in cisapride group (84.0%±11.7%, 77.1%±11.9% vs 66.3%±13.6%, P＜0.01, P＜0.05; 83.2%±5.5%, 81.7%±8.5% vs75.4%±5.9 %, P＜0.01, P＜0.05; 91.2%±2.2%,91.3%±3.9% vs 88.6%±3.5%,P＜0.05, P＜0.05). No difference of gastrointestinal propulsion rate was found between prucalopride 1 mg/kg group and prucalopride 2 mg/kg group (P＞0.05).CONCLUSION: Prucalopride accelerates intestinal motility in fast rats, and has no dose dependent effect.展开更多
文摘加世纪80年代以前，能性胃肠病（FGID）的研究主要集中在胃肠运动障碍上，胃肠运动障碍病在一定程度上被认为与FGID相同。虽然胃肠动力的研究已超过一个世纪，在临床实践中，胃肠运动障碍性疾病（Disorders of gastrointestinal motility）的诊断仍存在问题。过去20年，认识到胃肠运动活动受神经调控，并伴内脏感觉异常，以往医患双方常认为“痉挛”症状是动力异常引起，感知好即动力正常，胃肠道内存在异常感知也可以感到“痉挛痛”。神经胃肠病学的发展，对控制胃肠运动的复杂神经调控机制有了进一步的认识。
文摘AIM: To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatrnent of gastrointestinal motility diseases.METHODS: Gastrointestinal propulsion rate was measured by the migration rate of activated charcoal, which reflexes gastrointestinal motility function. 120 Spraque-Dawley rats were randomly divided into four groups and received an intravenous injection of physiological saline (served as control), prucalopdde 1 mg/kg, prucalopride 2 mg/kg and cisapride 1 mg/kg,respectively. The gastrointestinal propulsion rate was measured 1, 2 or 4 hours after intravenous injection of the drugs.RESULTS: Significant accelerations of gastrointestinal propulsion rate in prucalopride 1 mg/kg and 2 mg/kg groups were found compared with control group at 2 and 4 hours (83.2%±5.5%, 81.7%±8.5% vs70.5%±9.2%, P＜0.01;91.2%±2.2%, 91.3%±3.9% vs86.8%±2.6%, P＜0.01).The gastrointestinal propulsion rates at 1, 2 or 4 hours were faster in prucalopride 1 mg/kg and 2 mg/kg groups than in cisapride group (84.0%±11.7%, 77.1%±11.9% vs 66.3%±13.6%, P＜0.01, P＜0.05; 83.2%±5.5%, 81.7%±8.5% vs75.4%±5.9 %, P＜0.01, P＜0.05; 91.2%±2.2%,91.3%±3.9% vs 88.6%±3.5%,P＜0.05, P＜0.05). No difference of gastrointestinal propulsion rate was found between prucalopride 1 mg/kg group and prucalopride 2 mg/kg group (P＞0.05).CONCLUSION: Prucalopride accelerates intestinal motility in fast rats, and has no dose dependent effect.
