目的评估中医药减少艾滋病患者高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)所致胃肠道不良反应的临床疗效及安全性。方法采用随机、多中心、阳性对照的临床试验方法,对符合病例纳入标准的HIV/AIDS患者进行临床...目的评估中医药减少艾滋病患者高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)所致胃肠道不良反应的临床疗效及安全性。方法采用随机、多中心、阳性对照的临床试验方法,对符合病例纳入标准的HIV/AIDS患者进行临床治疗观察,试验组患者在常规HAART基础上,采用中医辨证治疗方案,对照组患者在常规HAART基础上,服用吗丁啉片,疗程为4周。结果共纳入HIV/AIDS患者354名,试验结束时,两组在恶心、呕吐、腹胀、腹泻及食欲不振等5种胃肠道不良反应症状的消除情况差异无统计学意义(P>0.05);治疗前后,5种胃肠道不良反应症状的严重程度总体上均有改善,但改善程度的组间差异无统计学意义(P>0.05);治疗结束时,两组检查指标正常转异常的发生率均无统计学差异(P>0.05);两组不良反应发生率分别为1.27%和0.88%,差异无统计学意义。结论中医药能够减少或改善HIV/AIDS患者因HAART导致的胃肠道不良反应,并具有良好的安全性,值得在临床上推广应用。展开更多
目的:评价针灸联合昂丹司琼片的针药结合的治疗策略在胃肠肿瘤化疗患者胃肠道反应中的干预效果。方法:受试对象来自于我院2022年4月至2023年4月收治的80例胃肠肿瘤化疗患者,排除因颅内转移、胃肠道梗阻导致的中枢性呕吐或器质性病变性...目的:评价针灸联合昂丹司琼片的针药结合的治疗策略在胃肠肿瘤化疗患者胃肠道反应中的干预效果。方法:受试对象来自于我院2022年4月至2023年4月收治的80例胃肠肿瘤化疗患者,排除因颅内转移、胃肠道梗阻导致的中枢性呕吐或器质性病变性呕吐患者后,结合盲法分组原则将患者依次纳入对照组(n = 40,予以昂丹司琼治疗)与研究组(n = 40,实施针灸联合昂丹司琼治疗),评价两组主要疗效、肝功能生化指标、安全性指标、营养状况。结果:较对照组,研究组患者症状积分水平更低(P 0.05)。结论:中医针灸配合昂丹司琼片形成的针药结合的治疗策略在满足了胃肠肿瘤化疗患者对胃肠道反应治疗需求的同时,也兼顾了安全性,价值显著,疗效确切,具有积极的应用前景。Objective: To evaluate the intervention efficacy of acupuncture combined with ondansetron tablets, a treatment strategy combining acupuncture and medicine, in the gastrointestinal response of patients with gastrointestinal tumor chemotherapy. Methods: Subjects were derived from 80 patients with gastrointestinal tumor chemotherapy admitted to our hospital from April 2022 to April 2023. After excluding patients with central vomiting due to intracranial metastasis, gastrointestinal obstruction, or vomiting due to organic lesions, patients were included in the control group (n = 40, ondansetron) and the study group (n = 40, acupuncture with ondansetron) in accordance with the principle of blinded grouping, to evaluate the main efficacy, biochemical index of liver function, safety index and nutritional status of the two groups. Results: Compared with the control group, the study group had a lower symptom score (P 0.05). Conclusion: The treatment strategy of acupuncture and medicine formed by Chinese acupuncture and moxibustion and ondansetron tablets not only meets the needs of gastrointestinal tumor chemotherapy patients for the treatment of gastrointestinal response, but also takes into account the safety, with significant value and definite efficacy, and has a positive application prospect.展开更多
文摘目的评估中医药减少艾滋病患者高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)所致胃肠道不良反应的临床疗效及安全性。方法采用随机、多中心、阳性对照的临床试验方法,对符合病例纳入标准的HIV/AIDS患者进行临床治疗观察,试验组患者在常规HAART基础上,采用中医辨证治疗方案,对照组患者在常规HAART基础上,服用吗丁啉片,疗程为4周。结果共纳入HIV/AIDS患者354名,试验结束时,两组在恶心、呕吐、腹胀、腹泻及食欲不振等5种胃肠道不良反应症状的消除情况差异无统计学意义(P>0.05);治疗前后,5种胃肠道不良反应症状的严重程度总体上均有改善,但改善程度的组间差异无统计学意义(P>0.05);治疗结束时,两组检查指标正常转异常的发生率均无统计学差异(P>0.05);两组不良反应发生率分别为1.27%和0.88%,差异无统计学意义。结论中医药能够减少或改善HIV/AIDS患者因HAART导致的胃肠道不良反应,并具有良好的安全性,值得在临床上推广应用。
文摘目的:评价针灸联合昂丹司琼片的针药结合的治疗策略在胃肠肿瘤化疗患者胃肠道反应中的干预效果。方法:受试对象来自于我院2022年4月至2023年4月收治的80例胃肠肿瘤化疗患者,排除因颅内转移、胃肠道梗阻导致的中枢性呕吐或器质性病变性呕吐患者后,结合盲法分组原则将患者依次纳入对照组(n = 40,予以昂丹司琼治疗)与研究组(n = 40,实施针灸联合昂丹司琼治疗),评价两组主要疗效、肝功能生化指标、安全性指标、营养状况。结果:较对照组,研究组患者症状积分水平更低(P 0.05)。结论:中医针灸配合昂丹司琼片形成的针药结合的治疗策略在满足了胃肠肿瘤化疗患者对胃肠道反应治疗需求的同时,也兼顾了安全性,价值显著,疗效确切,具有积极的应用前景。Objective: To evaluate the intervention efficacy of acupuncture combined with ondansetron tablets, a treatment strategy combining acupuncture and medicine, in the gastrointestinal response of patients with gastrointestinal tumor chemotherapy. Methods: Subjects were derived from 80 patients with gastrointestinal tumor chemotherapy admitted to our hospital from April 2022 to April 2023. After excluding patients with central vomiting due to intracranial metastasis, gastrointestinal obstruction, or vomiting due to organic lesions, patients were included in the control group (n = 40, ondansetron) and the study group (n = 40, acupuncture with ondansetron) in accordance with the principle of blinded grouping, to evaluate the main efficacy, biochemical index of liver function, safety index and nutritional status of the two groups. Results: Compared with the control group, the study group had a lower symptom score (P 0.05). Conclusion: The treatment strategy of acupuncture and medicine formed by Chinese acupuncture and moxibustion and ondansetron tablets not only meets the needs of gastrointestinal tumor chemotherapy patients for the treatment of gastrointestinal response, but also takes into account the safety, with significant value and definite efficacy, and has a positive application prospect.