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胃癌术后化疗联合四野盒式照射的治疗报告
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作者 张萍 吴式琇 +2 位作者 谢聪颖 王玉明 姚建高 《中国癌症杂志》 CAS CSCD 2004年第5期474-476,共3页
目的 :探讨胃癌术后化疗联合四野盒式放疗技术对中晚期胃癌的疗效和安全性。方法采用胃全切或胃次全切除加淋巴结扩大清扫 (D2 )术的胃癌 32例 ,采用直线加速器 6MVX线常规四野外照射 ,肿瘤量 4 6~ 5 0Gy ,同时在放疗的第 1~ 3天和第 ... 目的 :探讨胃癌术后化疗联合四野盒式放疗技术对中晚期胃癌的疗效和安全性。方法采用胃全切或胃次全切除加淋巴结扩大清扫 (D2 )术的胃癌 32例 ,采用直线加速器 6MVX线常规四野外照射 ,肿瘤量 4 6~ 5 0Gy ,同时在放疗的第 1~ 3天和第 2 9~ 31天给予紫杉醇 (135mg/m2 )和顺铂 (70mg/m2 )方案化疗二疗程。结果 :二年总生存率为 87.5 0 % ,二年无瘤生存率 81.2 5 % ,肝转移 4例 (6 .3% ) ,腹膜转移 2例 (6 .3% ) ,吻合口复发 2例 (12 .5 % ) ,经三维治疗计划系统DVH评价 ,90 %等剂量线包括整个临床靶区 ,除左肾外 ,OAR受量均在耐受剂量以下。结论 :胃癌术后四野放疗技术靶区剂量分布满意 ,无严重毒副反应 。 展开更多
关键词 肿瘤/外科学 胃肿瘤/放射治疗 剂量体积直方图
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Patients with brain metastases from gastrointestinal tract cancer treated with whole brain radiation therapy:Prognostic factors and survival 被引量:10
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作者 SusanneBartelt FelixMomm ChristianWeissenberger JohannesLutterbach 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第22期3345-3348,共4页
AIM: To identify the prognostic factors with regard to survival for patients with brain metastasis from primary tumors of the gastrointestinal tract. METHODS: Nine hundred and sixteen patients with brain metastases, t... AIM: To identify the prognostic factors with regard to survival for patients with brain metastasis from primary tumors of the gastrointestinal tract. METHODS: Nine hundred and sixteen patients with brain metastases, treated with whole brain radiation therapy (WBRT) between January 1985 and December 2000 at the Department of Radiation Oncology, University Hospital Freiburg, were analyzed retrospectively. RESULTS: Fifty-seven patients presented with a primary tumor of the gastrointestinal tract (esophagus: n=0, stomach: n=10, colorectal: n=47). Twenty-six patients had a solitary brain metastasis, 31 patients presented with multiple brain metastases. Surgical resection was performed in 25 patients. WBRT was applied with daily fractions of 2 Gray (Gy) or 3Gy to a total dose of 50Gy or 30Gy, respectively. The interval between diagnoses of the primary tumors and brain metastases was 22.6mo vs 8.0mo for patients with primary tumors of the colon/rectum vs other primary tumors, respectively (P<0.01, log-rank). Median overall survival for all patients with brain metastases (n=916) was 3.4mo and 3.2mo for patients with gastrointestinal neoplasms. Patients with gastrointestinal primary tumors presented significantly more often with a solitary brain metastasis than patients with other primary tumors (P<0.05, log-rank). In patients with gastrointestinal neoplasms (n=57), the median overall survival was 5.8 mo for patients with solitary brain metastasis vs 2.7mo for patients with multiple brain metastases (P<0.01, log-rank). The median overall survival for patients with a Karnofsky performance status (KPS) ≥70 was 5.5mo vs 2.1mo for patients with KPS <70 (P<0.01, log-rank). At multivariate analysis (Cox Model) the performance status and the number of brain metastases were identified as independent prognostic factors for overall survival. CONCLUSION: Brain metastases occur late in the course of gastrointestinal tumors. Pretherapeutic variables like KPS and the number of brain metastases have a profound influence on treatment outcome. 展开更多
关键词 ADULT Aged Aged 80 and over Brain Neoplasms FEMALE Gastrointestinal Neoplasms Humans MALE Middle Aged Prognosis Retrospective Studies Risk Factors Survival Analysis
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Premature chomosome condensation technique: A very promising approach to radiotherapy for digestive system cancers
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作者 Jian-She Yang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第44期7227-7227,共1页
Dear Editior-in-Chief, I am grateful to the renowned World Journal of Gastroenterology for publishing our manuscript about hepatoma radiosensitivity in volume 11 issue 26, page 4098-4101m, Since this paper appeared on... Dear Editior-in-Chief, I am grateful to the renowned World Journal of Gastroenterology for publishing our manuscript about hepatoma radiosensitivity in volume 11 issue 26, page 4098-4101m, Since this paper appeared online first, it was widely considered. Up to date, it has been cited four times in various journals covered by Science Citation IndexE241, and the click count and download count added up to 459 and 163tsl, respectively. 展开更多
关键词 CARBON-IONS
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基于4D-CT的放疗计划在胃癌中的应用价值
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作者 龚军 唐昃 +2 位作者 费国新 李荣峰 舒畅 《武汉大学学报(医学版)》 CAS 2015年第2期243-247,共5页
目的:比较分析4D-CT计划和常规3D-CT计划两种不同计划的靶区体积及相关剂量学方面的差异,评估4D-CT技术应用于胃癌放疗在剂量学方面的价值。方法:胃癌术后患者10例,在仰卧位平静自由呼吸下行CT模拟定位,先常规3D扫描再行4D扫描并根据呼... 目的:比较分析4D-CT计划和常规3D-CT计划两种不同计划的靶区体积及相关剂量学方面的差异,评估4D-CT技术应用于胃癌放疗在剂量学方面的价值。方法:胃癌术后患者10例,在仰卧位平静自由呼吸下行CT模拟定位,先常规3D扫描再行4D扫描并根据呼吸周期重建得到10个不同呼吸时相的CT图像。勾画完整的放疗靶区(GTVs、CTVs)及危及器官。在三维计划系统中,以20%的时相基准,分别根据计划靶体积(PTV3D、PTV4D)为10例患者各设计2套放射治疗计划,PTV3D在临床靶体积(CTV)的基础上外加常规安全边界,PTV4D是在10个时相CTV融合后形成的4D内靶体积(ITV4D)基础上外放摆位边界,比较两者靶区及正常组织在体积及相关剂量学方面的差异。结果:在靶区PTV覆盖率与剂量分布均匀性方面差异无显著性;4D计划较3D计划肝平均剂量明显下降(P<0.05),肝V30、V40有下降但差异无显著性(P>0.05);双肾V20及平均剂量未见显著差异(P>0.05);CTV3D与ITV4D的体积分别为(433.04±139.71)cm3和(535.44±150.89)cm3,后者体积增加了(102.40±21.77)cm3;PTV3D与PTV4D的体积分别为(860.87±226.52)cm3和(787.87±193.83)cm3,后者体积减少了(73.00±46.38)cm3,均具有显著的统计学差异。结论:3D计划存在夸大或遗漏靶区的风险,应用4D-CT能在不遗漏肿瘤放疗靶区的基础上尽可能的缩小靶体积,保护危及器官。 展开更多
关键词 胃肿瘤/放射治疗 4D-CT 靶区位移 内靶体积 自由呼吸
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卡莫氟加放疗在局部晚期贲门癌介入化疗后的临床研究 被引量:1
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作者 李焕义 赵红 +2 位作者 高宗毅 牛业来 姜玉棋 《肿瘤研究与临床》 CAS 2005年第5期345-346,共2页
目的讨论卡莫氟结合放射治疗在局部晚期贲门癌介入治疗后的临床研究。方法综合组先行介入动脉灌注化疗,化疗用FAM方案或FAD方案。介入治疗后2 ̄4周行放射治疗。放疗外照射使用直线加速器6MV-X线,常规照射(1.8 ̄2Gy/d,5次/周,总剂量64 ̄7... 目的讨论卡莫氟结合放射治疗在局部晚期贲门癌介入治疗后的临床研究。方法综合组先行介入动脉灌注化疗,化疗用FAM方案或FAD方案。介入治疗后2 ̄4周行放射治疗。放疗外照射使用直线加速器6MV-X线,常规照射(1.8 ̄2Gy/d,5次/周,总剂量64 ̄70Gy/6 ̄7周)。从放疗当日起开始服用卡莫氟200mg/次,3次/d,用药至放疗结束。结果近期疗效:单纯放疗组的完全消退率为20.5%(7/34),部分消退率为47.0%(16/34);综合治疗组的完全消退率为35.2%(12/34),部分消退率为50.0%(17/34)。两组比较差异有显著性意义(P<0.05)。远期疗效:单放组1,2,3年生存率70.5%(24/34),47.0%(16/34),14.7%(5/34),综合组1,2,3年生存率分别为88.2%(30/34),64.7%(22/34),23.5%(8/34),两组比较差异有显著性意义(P<0.05)。结论卡莫氟加放疗结合介入化疗治疗局部晚期贲门癌疗效肯定、复发率较低,和单纯放射治疗相比副作用无明显增加,1,2,3年生存率高于单放组。为治疗局部晚期贲门癌提供了一种新的途径。 展开更多
关键词 肿瘤/介入疗法 胃肿瘤/放射治疗 卡莫氟/放射增敏 肿瘤 综合治疗
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