观察对比氢溴酸山莨菪碱注射液与盐酸消旋山莨菪碱注射液治疗胃肠痉挛性腹痛的有效性和安全性。方法:对照组用盐酸消旋山莨菪碱注射液,试验组用氢溴酸山莨菪碱注射液。结果:试验组有效率高于对照组(96.34% VS 91.67%),差异有统计学意义(...观察对比氢溴酸山莨菪碱注射液与盐酸消旋山莨菪碱注射液治疗胃肠痉挛性腹痛的有效性和安全性。方法:对照组用盐酸消旋山莨菪碱注射液,试验组用氢溴酸山莨菪碱注射液。结果:试验组有效率高于对照组(96.34% VS 91.67%),差异有统计学意义(P<0.05);显效率两组差异无统计学意义(P>0.05)。NRS疼痛评分,两组用药前差异无统计学意义;用药30min后,试验组的评分低于对照组,差异有统计学意义(P<0.05)。试验组疼痛缓解短于对照组,差异有统计学意义(P<0.05);试验组疼痛消失时间短于对照组,差异有统计学意义(P<0.05)。用药30min后,试验组恶心抑制率高于对照组(93.24% vs 87.67%),差异有统计学意义(P<0.05);试验组呕吐抑制率高于对照组(97.75% VS 94.67%),差异有统计学意义(P<0.05)。试验组和对照组不良反应发生率(8.67% VS 5.35%),差异无统计学意义(P>0.05)。结论:氢溴酸山莨菪碱注射液用于胃肠痉挛性腹痛安全、有效,可缓解胃肠痉挛引发的恶心、呕吐等不适症状,值得临床进一步推广使用。展开更多
AIM:To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan. METHODS: In Japan, mature adults are offered regular check-ups for the prevention of ...AIM:To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan. METHODS: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged > 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period. RESULTS: The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year agegroup. Dysphagia was also significantly more frequent in female patients. CONCLUSION: The prevalence of typical GERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group.展开更多
Gastrointestinal involvement of neurof ibromatosis type 1 (NF1, Von Recklinghausen’s disease) is generally associated with the upper gastrointestinal tract. Abdominal manifestation of NF1 includes several tumors such...Gastrointestinal involvement of neurof ibromatosis type 1 (NF1, Von Recklinghausen’s disease) is generally associated with the upper gastrointestinal tract. Abdominal manifestation of NF1 includes several tumors such as malignant peripheral nerve sheath tumors, gastrointestinal stromal tumors and ampulla of vater tumors. However, colonic involvement in NF1 patients is rare. We report a case of a patient presenting with dysphagia, weight loss, intermittent abdominal pain and constipation caused by a single cecal neurof ibroma obstructing the ileocecal valve. Also gastrointestinal involvement of the lower tract should be considered in patients with NF1 presenting with abdominal complaints.展开更多
Vesical diverticula frequently result from bladder outlet obstructions. However, giant vesical diverticula which cause acute abdomen or intestinal obstruction are very rare. Our review of the English medical literatur...Vesical diverticula frequently result from bladder outlet obstructions. However, giant vesical diverticula which cause acute abdomen or intestinal obstruction are very rare. Our review of the English medical literature found 3 cases of bladder diverticula which caused gastrointestinal symptoms. Here, we present a 57-yearold man with a giant diverticulum of the urinary bladder who complained of abdominal pain, nausea and vomiting, constipation, no passage of gas or feces, and abdominal distension for 3 d. A 20 cm x 15 cm diverticulum was observed upon laparotomy. The colonic obstruction was secondary to external compression of the rectum against the sacrum by a distended vesical diverticulum. We performed a diverticulectomy and primary closure. Twelve months postoperatively, the patient had no difficulty with voiding or defecation.展开更多
文摘观察对比氢溴酸山莨菪碱注射液与盐酸消旋山莨菪碱注射液治疗胃肠痉挛性腹痛的有效性和安全性。方法:对照组用盐酸消旋山莨菪碱注射液,试验组用氢溴酸山莨菪碱注射液。结果:试验组有效率高于对照组(96.34% VS 91.67%),差异有统计学意义(P<0.05);显效率两组差异无统计学意义(P>0.05)。NRS疼痛评分,两组用药前差异无统计学意义;用药30min后,试验组的评分低于对照组,差异有统计学意义(P<0.05)。试验组疼痛缓解短于对照组,差异有统计学意义(P<0.05);试验组疼痛消失时间短于对照组,差异有统计学意义(P<0.05)。用药30min后,试验组恶心抑制率高于对照组(93.24% vs 87.67%),差异有统计学意义(P<0.05);试验组呕吐抑制率高于对照组(97.75% VS 94.67%),差异有统计学意义(P<0.05)。试验组和对照组不良反应发生率(8.67% VS 5.35%),差异无统计学意义(P>0.05)。结论:氢溴酸山莨菪碱注射液用于胃肠痉挛性腹痛安全、有效,可缓解胃肠痉挛引发的恶心、呕吐等不适症状,值得临床进一步推广使用。
文摘AIM:To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan. METHODS: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged > 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period. RESULTS: The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year agegroup. Dysphagia was also significantly more frequent in female patients. CONCLUSION: The prevalence of typical GERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group.
文摘Gastrointestinal involvement of neurof ibromatosis type 1 (NF1, Von Recklinghausen’s disease) is generally associated with the upper gastrointestinal tract. Abdominal manifestation of NF1 includes several tumors such as malignant peripheral nerve sheath tumors, gastrointestinal stromal tumors and ampulla of vater tumors. However, colonic involvement in NF1 patients is rare. We report a case of a patient presenting with dysphagia, weight loss, intermittent abdominal pain and constipation caused by a single cecal neurof ibroma obstructing the ileocecal valve. Also gastrointestinal involvement of the lower tract should be considered in patients with NF1 presenting with abdominal complaints.
文摘Vesical diverticula frequently result from bladder outlet obstructions. However, giant vesical diverticula which cause acute abdomen or intestinal obstruction are very rare. Our review of the English medical literature found 3 cases of bladder diverticula which caused gastrointestinal symptoms. Here, we present a 57-yearold man with a giant diverticulum of the urinary bladder who complained of abdominal pain, nausea and vomiting, constipation, no passage of gas or feces, and abdominal distension for 3 d. A 20 cm x 15 cm diverticulum was observed upon laparotomy. The colonic obstruction was secondary to external compression of the rectum against the sacrum by a distended vesical diverticulum. We performed a diverticulectomy and primary closure. Twelve months postoperatively, the patient had no difficulty with voiding or defecation.
