期刊文献+
共找到78篇文章
< 1 2 4 >
每页显示 20 50 100
陈宝贵胆胃双诊理论及临床应用 被引量:1
1
作者 张方辉 陈宝贵 《国医论坛》 2019年第4期48-49,共2页
目的:总结陈宝贵教授运用胆胃双诊理论治疗胆胃综合征的经验。方法:通过跟师临证,进行总结。结果:陈宝贵教授从生理功能和病理变化两个方面论述胆胃疾病的相互影响,提出胆胃双诊理论,认为调畅气机是治疗胆胃系统疾病的关键,常用代表方... 目的:总结陈宝贵教授运用胆胃双诊理论治疗胆胃综合征的经验。方法:通过跟师临证,进行总结。结果:陈宝贵教授从生理功能和病理变化两个方面论述胆胃疾病的相互影响,提出胆胃双诊理论,认为调畅气机是治疗胆胃系统疾病的关键,常用代表方为半夏泻心汤、柴胡疏肝散、四逆散、温胆汤加减等。结论:胆胃双诊理论治疗胆胃综合征确有实效,值得推广。 展开更多
关键词 疏胆和 陈宝贵 名医经验
下载PDF
急性上消化道出血的超急诊胃镜检查
2
作者 于建昌 张玉芳 +1 位作者 李清萍 谭建华 《临床荟萃》 CAS 北大核心 2001年第23期1099-1099,共1页
关键词 急性上消化道出血 胃诊
下载PDF
胃黏膜活检及病理诊断 被引量:5
3
作者 闵静 马騉 庞晓黎 《河北联合大学学报(医学版)》 2012年第6期767-767,共1页
胃黏膜活检是提高胃癌的检出率,特别是早期胃癌检出率的重要手段。为了提高胃黏膜活检的准确率,除了内窥镜医师在取材时应争取活检标本要深达黏膜肌,并避免活检对胃黏膜的过度挤压,以保证取到良好的标本外,还须注意胃黏膜标本脱水... 胃黏膜活检是提高胃癌的检出率,特别是早期胃癌检出率的重要手段。为了提高胃黏膜活检的准确率,除了内窥镜医师在取材时应争取活检标本要深达黏膜肌,并避免活检对胃黏膜的过度挤压,以保证取到良好的标本外,还须注意胃黏膜标本脱水、浸蜡、包埋、制片等技术要求,这些均是避免误诊和漏诊的前提。 展开更多
关键词 黏膜活检病理断漏
下载PDF
望龈诊胃法的体会
4
作者 黄国义 《实用中医内科杂志》 1999年第1期10-10,共1页
余从1995年5月~1997年8月,运用“望龈诊胃法”诊断胃肠道疾病209例,经“四诊合参”后,将其中186例作了胃镜、X线钡透、B超等检查,结果发现139例(占检人数74.7%)患了胃、肠、胆道疾病。现分析报道如下... 余从1995年5月~1997年8月,运用“望龈诊胃法”诊断胃肠道疾病209例,经“四诊合参”后,将其中186例作了胃镜、X线钡透、B超等检查,结果发现139例(占检人数74.7%)患了胃、肠、胆道疾病。现分析报道如下。1临床资料139例中男74例,女... 展开更多
关键词 疾病 望龈
下载PDF
A Comparison between biopsy and brilliant blue chromo -endoscopy in gastric cancer
5
作者 苏鲁 时敏 +2 位作者 刘彬 洪梅燕 潘洪珍 《World Journal of Gastroenterology》 SCIE CAS CSCD 1996年第1期34-35,33,共3页
AIMS To increase the discovering rate of early gastric cancer and the positive rate of biopsy,the brilliant blue(BB)chromo-en- doscopy and the routine endoscopy were used to examine 54 pa- tients with gastric cancer. ... AIMS To increase the discovering rate of early gastric cancer and the positive rate of biopsy,the brilliant blue(BB)chromo-en- doscopy and the routine endoscopy were used to examine 54 pa- tients with gastric cancer. METHODS BB staining method and steps:Othe examinee was injected IM 20 mg of Anisodamini Hydromidum;②he took a cup of BB solution;③after 40-60 min he was examined with the endoscope.All of the examinee were also examined with the rou- tine endoscope. RESULTS Sixteen of 54 patients were demonstrated to suffer from early gastric cancer,the detecting rate of early cancer being 29.4%.Among these,15 cases were discovered by BB endoscopy,and only 5 cases by the routine endoscopy.The for- mer is more sensitive in discovering early gastric cancer than the latter(P<0.01)o In addition,the BB endoscopy increases the positive rate of biopsy from 70.4%(38/54)to 94.4%(51. 54),which is clearly supperior in the diagnosis of gastric can- cer to that by routine endoscopy(P<0.01). CONCLUSIONS The BB chromo-endoscopy is more useful in following up the gastric precancerous lesion than the routine endoscopy. 展开更多
关键词 stomach neoplasms/diagnosis BIOPSY GASTROSCOPY
下载PDF
Endoscopic features predictive of gastric cancer in superficial lesions with biopsy-proven high grade intraepithelial neoplasia 被引量:17
6
作者 Wei Wu Yun-Lin Wu +4 位作者 Yan-Bo Zhu Qing Wei Yan Guo Zheng-Gang Zhu Yao-Zong Yuan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第4期489-495,共7页
AIM:To investigate the macroscopic and clinicopathologic features of gastric cancer in patients with biopsy-suggested high grade intraepithelial neoplasia. METHODS:Patients with biopsy-confirmed gastric high grade int... AIM:To investigate the macroscopic and clinicopathologic features of gastric cancer in patients with biopsy-suggested high grade intraepithelial neoplasia. METHODS:Patients with biopsy-confirmed gastric high grade intraepithelial neoplasia were reviewed from January 2001 to March 2008.Pathologic sections were re-evaluated by two senior pathologists. Patients with an en-bloc resection of the lesion within two months after the diagnosis of high grade intraepithelial neoplasia were enrolled in the study. Clinical manifestations,endoscopic features,biopsy and surgical pathology of all patients were collected and analyzed.The data acquired were subjected to univariate and multivariate analysis. RESULTS:Seventy-two superficial gastric lesions with a pathologic diagnosis of high grade intraepithelial neoplasia based on biopsy specimens were enrolled. True high grade intraepithelial neoplasia was finally proved in 16 lesions and gastric cancer in the rest 56 lesions,most of which(96.4%)were differentiated carcinomas.The result of univariate analysis indicatedthat the size and the presence of marked ulcer plaque or scar in a superficial lesion were independently associated with gastric cancer(P<0.05),when high grade intraepithelial neoplasia was diagnosed by biopsy pathology.The results of multivariate analysis revealed the size greater than 1.5 cm[odds ratio(OR)18.400,P<0.001]and the presence of 5-odd mm ulcer plaque or scar(OR 10.000,P=0.044)were associated with gastric cancer.Accordingly,the sensitivity,specificity and negative predictive value of multivariate analysis for predicting"true high grade intraepithelial neoplasia" was 87.5%,89.3%and 96.2%,respectively. CONCLUSION:Macroscopic findings are of value in differentiation between high grade intraepithelial neoplasia and superficial gastric cancer.This may simplify patient work-up and save costs for patients and healthcare system. 展开更多
关键词 Stomach neoplasm Precancerous conditions Carcinoma in situ ENDOSCOPY GASTROINTESTINAL Path-ology
下载PDF
p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer 被引量:50
7
作者 Mohammad Reza Abbaszadegan Omeed Moaven +8 位作者 Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第13期2055-2060,共6页
AIM: TO determine p15 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtai... AIM: TO determine p15 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter, p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P 〈 0.001). Methylation was significantly more frequent in higher pathological grades (P 〈 0.05). Methylation was not associated with other clinicopathological features and environmental factors including Hpylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. 展开更多
关键词 Gastric cancer P16 HYPERMETHYLATION Methylation specific PCR
下载PDF
Survivin:Potential role in diagnosis,prognosis and targeted therapy of gastric cancer 被引量:42
8
作者 Ting-Ting Wang Xiao-Ping Qian Bao-Rui Liu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第20期2784-2790,共7页
Survivin is a protein that is highly expressed in a vast number of malignancies,but is minimally expressed in normal tissues. It plays a role as an inhibitor of cell death in cancer cells,thus facilitating the growth ... Survivin is a protein that is highly expressed in a vast number of malignancies,but is minimally expressed in normal tissues. It plays a role as an inhibitor of cell death in cancer cells,thus facilitating the growth of these cells. In the case of gastric cancer,survivin is over-expressed in tumor cells and plays a role in the carcinogenesis process. Several studies on gastric cancer have indicated that there is a relationship between survivin expression and the ultimate behavior of the carcinoma. Since the expression pattern of survivin is selective to cancer cells,it has been described as an "ideal target" for cancer therapy. Currently,several pre-clinical and clinical trials are on-going to investigate the effects of interfering with survivin function in cancer cells as a biologic therapy. Survivin is a potentially significant protein in the diagnosis,prognosis and treatment of gastric tumors. 展开更多
关键词 SURVIVIN Gastric neoplasm DIAGNOSIS PROGNOSIS Targeted therapy
下载PDF
Rome Ⅲ:The functional gastrointestinal disorders, third edition, 2006 被引量:13
9
作者 Randa Mostafa 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第13期2124-2125,共2页
Functional gastrointestinal disorders (FGIDs) represent a common and important class of disorders within gastroenterology. Rome Ⅰ, the first edition was published in 1994, with symptom-based diagnostic criteria for... Functional gastrointestinal disorders (FGIDs) represent a common and important class of disorders within gastroenterology. Rome Ⅰ, the first edition was published in 1994, with symptom-based diagnostic criteria for FGIDs. These criteria began to change the diagnostic approach to F-GIDs, and no longer considered "diagnoses of exclusion" but rather "diagnoses of inclusion". Rome Ⅱ, the second edition published in 2000, resulted from the continual process of analyzing new scientific and clinical evidence in the study of F-GIDs. Rome Ⅱ, diagnostic criteria for irritable bowel syndrome (IBS), was extended with a focus on the frequency of symptoms occurring twelve weeks (not necessarily consecutive weeks) within twelve months. ROlE Ⅲ, the third edition, conservative one, was published in September 2006, with changes made only where there is good evidence to do so. Some of the differences between Rome Ⅱ and Rome Ⅲ criteria are highlighted in this issue. 展开更多
关键词 Rome Functional gastrointestinal disorders DIAGNOSIS CLASSIFICATION
下载PDF
Different faces of gastroparesis 被引量:8
10
作者 Klaus Bielefeldt Naeem Raza Susan L Zickmund 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第48期6052-6060,共9页
AIM: To test the hypothesis that pain and affect rather than impaired emptying determine symptom severity in patients with gastroparesis. METHODS: Adult patients with documented gastroparesis were enrolled prospecti... AIM: To test the hypothesis that pain and affect rather than impaired emptying determine symptom severity in patients with gastroparesis. METHODS: Adult patients with documented gastroparesis were enrolled prospectively in a single center and asked to complete the Gastroparesis Cardinal Symptom Index (GCSt), Hospital Anxiety and Depression Scale (HADS), the Short Form 12 (SF-12) as quality of life index, rate pain severity and answer 10 open-ended questions. RESULTS: A total of 55 patients (44 women) participated. Idiopathic (n = 29) or diabetic (n = 11) gastroparesis and connective tissue disease (n = 8) were the most common underlying causes. Antiemetics (n = 30) and prokinetics (n = 32) were most often prescribed. Seventeen patients used opioids on a daily basis. Nausea and/or vomiting (n = 28), pain (n = 24) and bloating (n = 14) were most commonly listed as dominant symptoms. Patients subjectively attributed symptom improvement to nutritional and dietary therapy (n= 11), prokinetics (n = 11), antiemetics (n = 10) or analgesic agents (n = 3). In univariate analyses, the physical subscore of the SF-12 and HADS, but not gastric emptying delay or symptom duration significantly correlated with disease severity as measured by the GCSI. In multivariate analyses, the combination of vomiting, bloating and depression best predicted the overall impact on quality of life. CONCLUSION: The study confirms the importance of pain and affect in gastroparesis, which requires novel approaches to improve more effectively the quality of life in patients with this disorder. 展开更多
关键词 PAIN DEPRESSION GASTROPARESIS Quality oflife
下载PDF
Circular RNA hsacirc0000745 may serve as a diagnostic marker for gastric cancer 被引量:43
11
作者 Mei Huang Yi-Ren He +2 位作者 Li-Chuan Liang Qiang Huang Zhi-Qiang Zhu 《World Journal of Gastroenterology》 SCIE CAS 2017年第34期6330-6338,共9页
AIM To determine whether circular RNAs(circ RNAs) are involved in pathological processes of gastric cancer(GC).METHODS Three circ RNAs with differential expression in GC and colorectal cancer were randomly selected fo... AIM To determine whether circular RNAs(circ RNAs) are involved in pathological processes of gastric cancer(GC).METHODS Three circ RNAs with differential expression in GC and colorectal cancer were randomly selected for validation by quantitative reverse transcription-polymerase chain reaction(q RT-PCR), using 20 pairs of gastric tissues and normal tissues. Based on the predicted circ RNAmi RNA network, we then focused on hsa_circ_0000745, which was found to be down-regulated in 20 GC tissues compared with normal tissues. The hsa_circ_0000745 levels were further analyzed by q RT-PCR in 60 GC tissues and paired adjacent non-tumor tissues, as well as 60 plasma samples from GC patients and 60 plasma samples from healthy controls. The associations between the levels of hsa_circ_0000745 and the clinicopathological features of GC patients were statistically assessed. A receiver operating characteristic(ROC) curve was used to evaluate the diagnostic value of hsa_circ_0000745 in GC.RESULTS Hsa_circ_0000745 was down-regulated in GC tissues vs non-tumorous tissues(P < 0.001) and in plasma samples from patients with GC vs healthy controls(P < 0.001). The expression level of hsa_circ_0000745 in GC tissues correlated with tumor differentiation, while the expression level in plasma correlated with tumor-nodemetastasis stage. The area under the ROC curve(AUC) of hsa_circ_0000745 in plasma was 0.683, suggesting good diagnostic value. Plasma hsa_circ_0000745 level combined with carcinoembryogenic antigen(CEA) level increased the AUC to 0.775.CONCLUSION Hsa_circ_0000745 plays an important role in GC and its expression level in plasma in combination with CEA level is a promising diagnostic marker for this malignancy. 展开更多
关键词 Circular RNA circ_0000745 Gastric cancer DIAGNOSIS Noncoding RNA
下载PDF
Role of symptoms in diagnosis and outcome of gastric cancer 被引量:13
12
作者 Giovanni Maconi Gianpiero Manes Gabriele Bianchi Porro 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第8期1149-1155,共7页
Gastric cancer is one of the most common cancers and the second most common cause of cancer deaths worldwide. Apart from Japan, where screening programmes have resulted in early diagnosis in asymptomatic patients, in ... Gastric cancer is one of the most common cancers and the second most common cause of cancer deaths worldwide. Apart from Japan, where screening programmes have resulted in early diagnosis in asymptomatic patients, in most countries the diagnosis of gastric cancers is invariably made on account on dyspeptic and alarm symptoms, which may also be of prognostic significance when reported by the patient at diagnosis. However, their use as selection criteria for endoscopy seems to be inconsistent since alarm symptoms are not sufficiently sensitive to detect malignancies. In fact, the overall prevalence of these symptoms in dyspeptic patients is high, while the prevalence of gastro-intestinal cancer is very low. Moreover, symptoms of early stage cancer may be indistinguishable from those of benign dyspepsia, while the presence of alarm symptoms may imply an advanced and often inoperable disease. The features of dyspeptic and alarm symptoms may reflect the pathology of the tumour and be of prognostic value in suggesting site, stage and aggressiveness of cancer. Alarm symptoms in gastric cancer are independently related to survival and an increased number, as well as specific alarm symptoms, are closely correlated to the risk of death.Dysphagia, weight loss and a palpable abdominal mass appear to be major independent prognostic factors in gastric cancer, while gastro-intestinal bleeding, vomiting and also duration of symptoms, do not seem to have a relevant prognostic impact on survival in gastric cancer. 展开更多
关键词 Gastric cancer SYMPTOMS DIAGNOSIS Survival Cancer stage Alarm symptoms DYSPEPSIA
下载PDF
Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer 被引量:5
13
作者 Tadayuki Shishido Taketo Yamaguchi +3 位作者 Takeo Odaka Masanori Seimiya Hiromitsu Saisho Fumio Nomura 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第44期6905-6909,共5页
AIM: To investigate the usefulness of sucrose permeability test using serum in the diagnosis of gastric diseases, with special reference to early gastric cancer (EGC). METHODS: A total of 63 subjects, including 11... AIM: To investigate the usefulness of sucrose permeability test using serum in the diagnosis of gastric diseases, with special reference to early gastric cancer (EGC). METHODS: A total of 63 subjects, including 11 patients with gastric ulcer, 20 patients with gastric cancer (13, early; 7, advanced) and 32 healthy controls, were studied. Blood and urine samples were collected repeatedly for 5 h before and after the sucrose loading. Sucrose levels were measured by a newly developed RESULTS: Serum sucrose levels started to increase 15 min after loading, and peaked at 60 min in the gastric disease groups. The levels for gastric ulcer, EGC and advanced gastric cancer (AGC) at 60 min were significantly higher than that in the healthy controls (26.9±2.4, 34.4±5.0, and 71.8±15.6 vs 7.9±0.7 mol/L, respectively, P〈0.01). The cut-off level set at 15.4 mol/L (60 min) offered the best distinction between EGC patients and healthy controls; and the sensitivity and specificity were 92.3% and 93.8%, respectively, while those of the urine method were 76.9% and 93.8%, respectively. CONCLUSIONS: The gastric permeability test using serum is reliable for the detection of EGC, and this test can provide results much earlier than the conventional urine method. This test may offer a useful alternative to more invasive tests for EGC. 展开更多
关键词 Sucrose test Gastric permeability Early gastric cancer Advanced gastric cancer Gastric ulcer
下载PDF
OMOM capsule endoscopy in diagnosis of small bowel disease 被引量:10
14
作者 Chen-yi LI Bing-ling ZHANG Chun-xiao CHEN You-ming LI 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2008年第11期857-862,共6页
Objective: To assess the diagnostic efficiency of OMOM capsule endoscopy (CE) in a group of patients with different indications. Methods: Data from 89 consecutive patients (49 males, 40 females) with suspected s... Objective: To assess the diagnostic efficiency of OMOM capsule endoscopy (CE) in a group of patients with different indications. Methods: Data from 89 consecutive patients (49 males, 40 females) with suspected small bowel disease who underwent OMOM CE (Jinshan Science and Technology Company, review. The patients' indications of the disease consisted of the Chongqing, China) examination were obtained by retrospective following: obscure gastrointestinal bleeding (OGIB), abdominal pain or diarrhea, partial intestinal obstruction, suspected inflammatory bowel disease, tumor of unknown origin, hypoproteinemia, constipation, weight loss, and elevated tumor markers. Results: CE failed in one patient. Visualization of the entire small bowel was achieved in 75.0%. Capsules were naturally excreted by all patients. The detection rate of abnormalities was 70.5% for patients with suspected small bowel disease, and the diagnostic yield for patients with OGIB was higher than that for patients with abdominal pain or diarrhea (85.7% vs 53.3%, P〈0.005). Angiodysplasia was the most common small bowel finding. Active bleeding sites were noted in the small intestine in 11 cases. Conclusion: OMOM CE is a useful diagnostic tool for the diagnosis of variably suspected small bowel disease, whose diagnostic efficiency is similar to that of the Pillcam SB (small bowel) CE (Given Imaging, Yoqneam, Israel). 展开更多
关键词 OMOM capsule endoscopy (CE) Small bowel disease Obscure gastrointestinal bleeding (OGIB) DIAGNOSIS
下载PDF
Gastroparesis: Current diagnostic challenges and management considerations 被引量:72
15
作者 Shamaila Waseem Baharak Moshiree Peter V Draganov 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第1期25-37,共13页
Gastroparesis refers to abnormal gastric motility characterized by delayed gastric emptying in the absence of mechanical obstruction. The most common etiologies include diabetes, post-surgical and idiopathic. The most... Gastroparesis refers to abnormal gastric motility characterized by delayed gastric emptying in the absence of mechanical obstruction. The most common etiologies include diabetes, post-surgical and idiopathic. The most common symptoms are nausea, vomiting and epigastric pain. Gastroparesis is estimated to affect 4% of the population and symptomatology may range from little effect on daily activity to severe disability and frequent hospitalizations. The gold standard of diagnosis is solid meal gastric scintigraphy. Treatment is multimodal and includes dietary modification, prokinetic and anti-emetic medications, and surgical interventions. New advances in drug therapy, and gastric electrical stimulation techniques have been introduced and might provide new hope to patients with refractory gastroparesis. In this comprehensive review, we discuss gastroparesis with emphasis on the latest developments; from the perspective of the practicing clinician. 展开更多
关键词 Gastroparesis Nausea VOMITING PROKINETIC Therapy
下载PDF
Possibility of non-invasive diagnosis of gastric mucosal precancerous changes 被引量:7
16
作者 Victor D.Pasechnikov Sergey Z.Chukov +3 位作者 Sergey M. Kotelevets Alexander N. Mostovov Varvara P. Mernova Maria B. Polyakova 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第21期3146-3150,共5页
AIM: To assess the possibility of non-invasive screening of atrophic chronic gastritis for preventing further development of gastric cancer.METHODS: One hundred and seventy-eight consecutive Helicobacter pylori ( H py... AIM: To assess the possibility of non-invasive screening of atrophic chronic gastritis for preventing further development of gastric cancer.METHODS: One hundred and seventy-eight consecutive Helicobacter pylori ( H pylori)-positive dyspeptic patients after detection of serum levels of pepsinogen-1 (PG-1) and gastrin-17 (G-17) by enzyme immunoassay were proposed for endoscopy and histology. The serologic and morphologic results were compared with estimating the sensitivity, specificity and prognostic values of the tests.RESULTS: There was statistically significant reverse dependence between the grade of stomach mucosal antral or corpus atrophy and the proper decreasing of serum G17 or PG1 levels. The serologic method was quite sensitive in the diagnosis of non-atrophic and severe antral and corpus gastritis. Also, it was characterized by the high positive and negative prognostic values.CONCLUSION: Detection of serum G-17 and PG1 levels can be offered as the screening tool for atrophic gastritis. The positive serologic results require further chromoendoscopy with mucosal biopsy, for revealing probable progressing of atrophic process with development of intestinal metaplasia, dysplasia or gastric cancer. 展开更多
关键词 Helicobacter pylori ATROPHY Biological Markers Biopsy Gastric Mucosa GASTRINS GASTRITIS Helicobacter Infections Humans Immunoenzyme Techniques Mass Screening Pepsinogen A Precancerous Conditions Sensitivity and Specificity
下载PDF
Application of Stool-PCR test for diagnosis of Helicobacter pylori infection in children 被引量:5
17
作者 Tahereh Falsafi Raha Favaedi +1 位作者 Fatemeh Mahjoub Mehri Najafi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第4期484-488,共5页
AIM: To evaluate the usefulness of stooI-PCR test for diagnosis of Helicobacter pylori (H pylon) infection in pediatric populations. METHODS: Based on endoscopic features (including nodular gastritis, erosive duo... AIM: To evaluate the usefulness of stooI-PCR test for diagnosis of Helicobacter pylori (H pylon) infection in pediatric populations. METHODS: Based on endoscopic features (including nodular gastritis, erosive duodenitis and ulcer) and/or a positive rapid urease test (RUT) obtained during endoscopy, 28 children from a group of children admitted to the Children's Medical Center of Tehran for persistent upper gastrointestinal problems were selected to compare biopsy-based tests with stool- PCR. Their gastric activity and bacterial density were graded by the updated Sydney system, and their first stool after endoscopy was stored at -70℃. Biopsies were cultured on modified campy-blood agar plates and identified by gram-staining, biochemical tests, and PCR. Two methods of phenol-chloroform and boiling were used for DNA extraction from H pylori isolates. Isolation of DNA from stool was performed using a stool DNA extraction kit (Bioneer Inc, Korea). PCR was performed using primers for detection of vacA, cagA, and 16srRNA genes in both isolates and stool. RESULTS: Sixteen out of 28 child patients (57%) were classified as H pylori positive by biopsy-based tests, of which 11 (39%) were also positive by stool- PCR. Sensitivity and specificity of stool-PCR was 62.5% and 92.3% respectively. H pylori was observed in histological sections for 10 out of 11 stool-positive patients. Association was observed between higher score of H pylori in histology and positivity of stool- PCR. Also association was observed between the more severe form of gastritis and a positive stool-PCR. CONCLUSION: Association between higher score of H pylori in histology and a positive stool-PCR make it a very useful test for detection of H pylori active infection in children. We also suggest that a simple stool-PCR method can be a useful test for detection of Hpylori virulence genes in stool. 展开更多
关键词 Helicobacter pylori Non-invasive diagnosis Stool-PCR HISTOLOGY SCORE CHILDREN Iran
下载PDF
Gastrointestinal stromal tumour of the rectum: Report of a case and review of literature 被引量:6
18
作者 Nello Grassi Calogero Cipolla +4 位作者 Adriana Torcivia Stefano Mandalà Giuseppa Graceffa Alessandro Bottino Federica Latteri 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第8期1302-1304,共3页
Gastrointestinal stromal tumour (GIST) is a rare tumour of the gastrointestinal tract which does not generally originate in the rectum. The authors describe a case of a 70-year-old man who underwent an anterior rese... Gastrointestinal stromal tumour (GIST) is a rare tumour of the gastrointestinal tract which does not generally originate in the rectum. The authors describe a case of a 70-year-old man who underwent an anterior resection of the rectum for a low-risk GIST. The patient was not given adjuvant chemotherapy with imatinib and is still disease-free 30 mo after surgery. The authors conclude that although rectal GIST is extremely uncommon, it should be included in differential diagnosis when a tumour in the rectum is detected. Biopsy of the tumour is essential, since this makes it possible to reach a sure preoperative diagnosis based on the immunohistological features of the CDl17 and CD34. Although complete surgical resection with negative tumour margins is the principal curative procedure for primary and nonmetastatic tumours, further studies are still needed for the determination of the most effective treatment strategy for patients with rectal GIST. 展开更多
关键词 RECTAL Gastrointestinal stromal tumour DIAGNOSIS Treatment SURGERY
下载PDF
Gastric atrophy,diagnosing and staging 被引量:2
19
作者 Hala MT El-Zimaity 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第36期5757-5762,共6页
Hpylori is now accepted as the cause of gastritis and gastritis-associated diseases, such as duodenal ulcer, gastric ulcer, gastric carcinoma, and gastric MALT lymphoma. The natural history of H pylori gastritis inclu... Hpylori is now accepted as the cause of gastritis and gastritis-associated diseases, such as duodenal ulcer, gastric ulcer, gastric carcinoma, and gastric MALT lymphoma. The natural history of H pylori gastritis includes inflammation progressing from the antrum into the adjacent corpus resulting in an atrophic front of advancing injury leading to a reduction in acid secretion and eventual loss of parietal cells and development of atrophy. Sub-typing intestinal metaplasia has no clinical value to the patient, the pathologist, or the endoscopist. The pattern, extent, and severity of atrophy, with or without intestinal metaplasia, is a far more important predictor than is intestinal metaplasia subtype. The challenge remains to identify a reliable marker that relates to pre-malignant potential. 展开更多
关键词 Gastric atrophy DIAGNOSIS STAGING HPYLORI
下载PDF
Primary gastric melanoma: A case report 被引量:8
20
作者 Emmanuel Eustathios Lagoudianakis Michael Genetzakis +5 位作者 Dimitrios Konstantinos Tsekouras Artemisia Papadima Georgia Kafiri Konstantinos Toutouzas Vaggelogiannis Katergiannakis Andreas Manouras 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第27期4425-4427,共3页
Melanoma accounts for 1-3 per cent of all malignant tumors. Except cutaneous, other less common melanomas include, among others, those in the GI tract. However, their primary or secondary nature is often difficult to ... Melanoma accounts for 1-3 per cent of all malignant tumors. Except cutaneous, other less common melanomas include, among others, those in the GI tract. However, their primary or secondary nature is often difficult to establish. Referring to the stomach, scattered cases of primary melanomas have been reported in the literature. We report a case of a man with an ulcerated submucosal mass at the antrum of the stomach, manifested with dull upper abdominal pain, nausea, vomiting, fatigue and anemia. This lesion was histologically proved to be melanoma. A detailed clinical and laboratory investigation revealed no primary site elsewhere. To our knowledge, very few cases of primary gastric melanoma have been reported. Our case is the fourth ever published and the first located at the antrum of the stomach. The debate upon the primitive nature of such lesions still persists. Thus, specific diagnostic criteria have been proposed. 展开更多
关键词 Primary gastric melanoma MANIFESTATIONS DIAGNOSIS
下载PDF
上一页 1 2 4 下一页 到第
使用帮助 返回顶部