目的探讨不同甘油三酯相关指标,即甘油三酯高密度脂蛋白胆固醇比值(triglyceride to high density lipoprotein cholesterol ratio,TG/HDL-C)、甘油三酯葡萄糖乘积指数(triglyceride glucose index,TyG指数)及相关参数与非酒精性脂肪性...目的探讨不同甘油三酯相关指标,即甘油三酯高密度脂蛋白胆固醇比值(triglyceride to high density lipoprotein cholesterol ratio,TG/HDL-C)、甘油三酯葡萄糖乘积指数(triglyceride glucose index,TyG指数)及相关参数与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的相关性及在NAFLD疾病预测中的应用价值。方法选取2022年1—4月在新疆医科大学第一附属医院参与健康检查的608例体检者为研究对象;根据B型超声影像学参数结果,分为NAFLD组(328例)和非NAFLD组(280例),比较两组间各临床相关指标差异;采用logistic回归分析五种甘油三酯相关指标与NAFLD之间的相关性,并运用受试者工作特征曲线(receiver operating characteristic curve,ROC)进一步分析其在NAFLD疾病筛查中的预测价值。结果logistic回归分析结果显示,在五种甘油三酯相关指标中,无论调整混杂因素前或后,均以TyG指数-腰高比(triglyceride glucose index-waist height ratio,TyG-WHtR)的比值比最为显著,分别为13.485(95%CI:8.919~20.389)和12.559(95%CI:7.729~20.405)。ROC曲线结果分析显示,五种甘油三酯相关指标预测NAFLD的ROC曲线下面积(area under the curve,AUC)均大于0.7(P<0.05);其中,TyG指数-体质指数(triglyceride glucose index-body mass index,TyG-BMI)在18~40岁男性受试者中预测NAFLD的AUC最大,为0.871(95%CI:0.797~0.926);TyG指数-腰围(triglyceride glucose index-waist circumference,TyG-WC)预测总体男性、女性、体质指数(body mass index,BMI)<24人群以及40岁以上女性受试者的AUC最大,分别为0.850(95%CI:0.805~0.888)、0.908(95%CI:0.869~0.938)、0.840(95%CI:0.783~0.888)和0.913(95%CI:0.864~0.949);TyG-WHtR预测BMI≥24人群、18~40岁女性受试者以及40岁以上男性受试者的AUC最大,分别为0.803(95%CI:0.761~0.841)、0.904(95%CI:0.835~0.952)和0.851(95%CI:0.791~0.899)。结论TG/HDL-C、TyG指数及相关参数与NAFLD密切相关,其中与TyG指数相关的参数对NAFLD具有更高的预测价值。展开更多
Objective:The aim of this study was to investigate lipid disorders and lipid peroxidation associated with the malignant transformation of colorectal adenoma.Methods:Analyses were based on data from 100 subjects with h...Objective:The aim of this study was to investigate lipid disorders and lipid peroxidation associated with the malignant transformation of colorectal adenoma.Methods:Analyses were based on data from 100 subjects with histologically confirmed adenomas(cases) and 50 adenoma-free control subjects,all of whom had colonoscopy.The subjects were divided into two groups:those with no adenoma and those with adenoma.According to subsite of adenomas the subjects with adenoma were divided into group of distal adenoma and group of proximal adenoma.According to histology of adenomas the subjects with adenoma were divided into group of villiform adenoma and group of tubular + tubulo-villous adenoma.Among the groups,the serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),lowdensity lipoprotein cholesterol(LDL-C),and lipid peroxidation product malondialdehyde(MDA) were compared in all the patients.Results:Plasma total cholesterol and MDA level in group of adenomas were significantly higher than that in group of control subjects,but plasma HDL-C level was low in group of adenomas(P<0.05).Plasma total cholesterol and MDA levels were positively related to distal and villiform adenomas(P<0.05).Conclusion:The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas.展开更多
AIM： To investigate the association between metabolic syndrome （NetS） and the development of gallstone disease （GSD）. METHODS： A cross-sectional study was conducted in 7570 subjects （4978 men aged 45.0：1：8.8 ...AIM： To investigate the association between metabolic syndrome （NetS） and the development of gallstone disease （GSD）. METHODS： A cross-sectional study was conducted in 7570 subjects （4978 men aged 45.0：1：8.8 years, and 2592 women aged 45.3：1：9.5 years） enrolled from the physical check-up center of the hospital. The subjects included 918 patients with gallstones （653 men and 265 women） and 6652 healthy controls （4325 men and 2327 women） without gallstones. Body mass index （BII）, waist circumference, blood pressure, fasting plasma glucose （FPG） and serum lipids and lipoproteins levels were measured. Colorimetric method was used to measure cholesterol, high-density lipoprotein cho- lesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C）. Dextrose oxidizing enzyme method was used to measure FPG. Subjects were asked to complete a questionnaire that enquired about the information on demographic data, age, gender, histories of diabetes mellitus, hypertension, and chronic liver disease and so on. Metabolic syndrome was diagnosed according to the Adult Treatment Panel HI （ATP ]3） criteria. Gall- stones were defined by the presence of strong intralu- minal echoes that were gravity-dependent or attenu- ated ultrasound transmission. RESULTS： Among the 7570 subjects, the prevalence of the gallstone disease was 12.1% （13.1% in men and 10.2% in women）. BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose and serum triglyceride （TG） in cases group were higher than in controls, while serum high-density lipid was lower than in controls. There were significant differences in the waist circumference, blood pressure, FPG and TG between cases and controls. In an age- adjusted logistic regression model, metabolic syndrome was associated with gallstone disease. The age-adjust- ed odds ratio of MetS for GSD in men was 1.29 [95% confidence interval （CI）, 1.09-1.52; P = 0.0030], and 1.68 （95% CI, 1.26-2.25; P = 0.0004） in women; the overall age-adjusted odds ratio of NetS for GSD was 1.42 （95% CI, 1.23-1.64; P 〈 0.0001）. The men with more metabolic disorders had a higher prevalence of gallstone disease, the trend had statistical significance （P 〈 0.0001）. The presence of 5 components of the MetS increased the risk of gallstone disease by 3.4 times （P 〈 0.0001）. The prevalence of GSD in women who had 5 components of NetS was 5 times higher than in those without Nets component. The more the components of Mets, the higher the prevalence of GSD （P 〈 0.0001）. The presence of 5 components of the Mets increased the risk of gallstone disease by 4.0 times. CONCLUSION： GSD appears to be strongly associated with MetS, and the more the components of NetS, the higher the prevalence of GSD.展开更多
Objective To compare and rank the clinical effects of different acupuncture and related therapies on hyperlipidemia patients.Methods We used network meta-analysis(NMA)to evaluate direct and indirect effects in studies...Objective To compare and rank the clinical effects of different acupuncture and related therapies on hyperlipidemia patients.Methods We used network meta-analysis(NMA)to evaluate direct and indirect effects in studies of acupuncture and related therapies for hyperlipidemia.Databases PubMed,EMBASE,Cochrane Library,the China Biology Medicine(CBM),the China National Knowledge Infrastructure(CNKI),Wanfang Data and the Chinese Scientific Journal Database(VIP)were searched to collect randomized controlled trials(RCTs)of acupuncture and related therapies in the treatment of hyperlipidemia.The data were analyzed using Stata 15.0 and WinBUGS 1.4.3 software after two researchers independently screened the literature,extracted the data,and assessed the risk of bias in the included studies.Results We analyzed a total of 36 eligible studies that included 3124 patients,involving 12 types of acupuncture and related therapies and comprehensive therapies.The results of the NMA showed that:for the total cholesterol(TC),acupoint catgut embedding(ACE),simple acupuncture(ACU),acupoint injection(AI),electroacupuncture(EA),western medicine of statins(WM),and combination of acupuncture and related therapies(combined therapies)were all more effective than placebo(P<0.05).For triacylglycerol(TG),ACU,EA,warming acupuncture(WA),WM and combined therapies were better than placebo(P<0.05),while WA was better than Chinese herb(CH)(P<0.05).For low-density lipoprotein cholesterol(LDL-C),combined therapies were more effective than lifestyle modification(LM)(P<0.05).For high-density lipoprotein cholesterol(HDL-C),auricular acupoint stimulation(AAS),ACE,ACU,AI,CH,EA,LM,moxibustion(MOX),WM,combined therapies and placebo were all worse than WA(P<0.05),while WM and combined therapies were better than ACU(P<0.05).Combined ranking results suggest that ACU and combined therapies may be the optimal intervention.Conclusions The efficacy of all kinds of acupuncture-related therapies in patients with hyperlipidemia is better than lifestyle changes.However,for different outcome indicators,all kinds of acupuncture-related therapies have their advantages and disadvantages,and comprehensive ranking results suggest that ACU and combined therapies may be the optimal intervention.展开更多
Objective: To observe the effect of acupuncture on simple obesity and cellular hemorheology. Methods: Thirty-two cases of simple obesity patients were enrolled into this study. Acupoints of the Stomach Meridian and Sp...Objective: To observe the effect of acupuncture on simple obesity and cellular hemorheology. Methods: Thirty-two cases of simple obesity patients were enrolled into this study. Acupoints of the Stomach Meridian and Spleen Meridian as Zhongwan (中脘 CV 12), Liangmen (梁门 ST 21), Tianshu (天枢 ST 25), Guayuan (关元 CV 4), etc. were punctured, once daily in the first 5 days, and once every other day afterwards, with 10 sessions being a therapeutic course. Before treatment and after 3 courses of treatment, the body weight, waistline, weight index, seam cholesterol (CH), triglyceride and aggregation index of red blood cell (RBC) were detected. Results: After acupuncture treatment, all the indexes of body weight, waistline, weight index, serum CH, triglyceride and aggregation index of RBC decreased significantly in comparison with those of pre-treatment(P< 0.05). Conclusion: Acupuncture can apparently improve cellular hemorheology, reduce body weight, serum cholesterol and TG levels in simple obesity patients.展开更多
文摘目的探讨不同甘油三酯相关指标,即甘油三酯高密度脂蛋白胆固醇比值(triglyceride to high density lipoprotein cholesterol ratio,TG/HDL-C)、甘油三酯葡萄糖乘积指数(triglyceride glucose index,TyG指数)及相关参数与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的相关性及在NAFLD疾病预测中的应用价值。方法选取2022年1—4月在新疆医科大学第一附属医院参与健康检查的608例体检者为研究对象;根据B型超声影像学参数结果,分为NAFLD组(328例)和非NAFLD组(280例),比较两组间各临床相关指标差异;采用logistic回归分析五种甘油三酯相关指标与NAFLD之间的相关性,并运用受试者工作特征曲线(receiver operating characteristic curve,ROC)进一步分析其在NAFLD疾病筛查中的预测价值。结果logistic回归分析结果显示,在五种甘油三酯相关指标中,无论调整混杂因素前或后,均以TyG指数-腰高比(triglyceride glucose index-waist height ratio,TyG-WHtR)的比值比最为显著,分别为13.485(95%CI:8.919~20.389)和12.559(95%CI:7.729~20.405)。ROC曲线结果分析显示,五种甘油三酯相关指标预测NAFLD的ROC曲线下面积(area under the curve,AUC)均大于0.7(P<0.05);其中,TyG指数-体质指数(triglyceride glucose index-body mass index,TyG-BMI)在18~40岁男性受试者中预测NAFLD的AUC最大,为0.871(95%CI:0.797~0.926);TyG指数-腰围(triglyceride glucose index-waist circumference,TyG-WC)预测总体男性、女性、体质指数(body mass index,BMI)<24人群以及40岁以上女性受试者的AUC最大,分别为0.850(95%CI:0.805~0.888)、0.908(95%CI:0.869~0.938)、0.840(95%CI:0.783~0.888)和0.913(95%CI:0.864~0.949);TyG-WHtR预测BMI≥24人群、18~40岁女性受试者以及40岁以上男性受试者的AUC最大,分别为0.803(95%CI:0.761~0.841)、0.904(95%CI:0.835~0.952)和0.851(95%CI:0.791~0.899)。结论TG/HDL-C、TyG指数及相关参数与NAFLD密切相关,其中与TyG指数相关的参数对NAFLD具有更高的预测价值。
基金Supported in part by Natural Science Foundation of Hubei Province (No. 302-131703)
文摘Objective:The aim of this study was to investigate lipid disorders and lipid peroxidation associated with the malignant transformation of colorectal adenoma.Methods:Analyses were based on data from 100 subjects with histologically confirmed adenomas(cases) and 50 adenoma-free control subjects,all of whom had colonoscopy.The subjects were divided into two groups:those with no adenoma and those with adenoma.According to subsite of adenomas the subjects with adenoma were divided into group of distal adenoma and group of proximal adenoma.According to histology of adenomas the subjects with adenoma were divided into group of villiform adenoma and group of tubular + tubulo-villous adenoma.Among the groups,the serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),lowdensity lipoprotein cholesterol(LDL-C),and lipid peroxidation product malondialdehyde(MDA) were compared in all the patients.Results:Plasma total cholesterol and MDA level in group of adenomas were significantly higher than that in group of control subjects,but plasma HDL-C level was low in group of adenomas(P<0.05).Plasma total cholesterol and MDA levels were positively related to distal and villiform adenomas(P<0.05).Conclusion:The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas.
文摘AIM： To investigate the association between metabolic syndrome （NetS） and the development of gallstone disease （GSD）. METHODS： A cross-sectional study was conducted in 7570 subjects （4978 men aged 45.0：1：8.8 years, and 2592 women aged 45.3：1：9.5 years） enrolled from the physical check-up center of the hospital. The subjects included 918 patients with gallstones （653 men and 265 women） and 6652 healthy controls （4325 men and 2327 women） without gallstones. Body mass index （BII）, waist circumference, blood pressure, fasting plasma glucose （FPG） and serum lipids and lipoproteins levels were measured. Colorimetric method was used to measure cholesterol, high-density lipoprotein cho- lesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C）. Dextrose oxidizing enzyme method was used to measure FPG. Subjects were asked to complete a questionnaire that enquired about the information on demographic data, age, gender, histories of diabetes mellitus, hypertension, and chronic liver disease and so on. Metabolic syndrome was diagnosed according to the Adult Treatment Panel HI （ATP ]3） criteria. Gall- stones were defined by the presence of strong intralu- minal echoes that were gravity-dependent or attenu- ated ultrasound transmission. RESULTS： Among the 7570 subjects, the prevalence of the gallstone disease was 12.1% （13.1% in men and 10.2% in women）. BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose and serum triglyceride （TG） in cases group were higher than in controls, while serum high-density lipid was lower than in controls. There were significant differences in the waist circumference, blood pressure, FPG and TG between cases and controls. In an age- adjusted logistic regression model, metabolic syndrome was associated with gallstone disease. The age-adjust- ed odds ratio of MetS for GSD in men was 1.29 [95% confidence interval （CI）, 1.09-1.52; P = 0.0030], and 1.68 （95% CI, 1.26-2.25; P = 0.0004） in women; the overall age-adjusted odds ratio of NetS for GSD was 1.42 （95% CI, 1.23-1.64; P 〈 0.0001）. The men with more metabolic disorders had a higher prevalence of gallstone disease, the trend had statistical significance （P 〈 0.0001）. The presence of 5 components of the MetS increased the risk of gallstone disease by 3.4 times （P 〈 0.0001）. The prevalence of GSD in women who had 5 components of NetS was 5 times higher than in those without Nets component. The more the components of Mets, the higher the prevalence of GSD （P 〈 0.0001）. The presence of 5 components of the Mets increased the risk of gallstone disease by 4.0 times. CONCLUSION： GSD appears to be strongly associated with MetS, and the more the components of NetS, the higher the prevalence of GSD.
基金We thank for the funding support from the“Qihuang”Project on the Inheritance and Innovation of Traditional Chinese Medicine funded by National Administration of Traditional Chinese Medicine(No.284,2018).
文摘Objective To compare and rank the clinical effects of different acupuncture and related therapies on hyperlipidemia patients.Methods We used network meta-analysis(NMA)to evaluate direct and indirect effects in studies of acupuncture and related therapies for hyperlipidemia.Databases PubMed,EMBASE,Cochrane Library,the China Biology Medicine(CBM),the China National Knowledge Infrastructure(CNKI),Wanfang Data and the Chinese Scientific Journal Database(VIP)were searched to collect randomized controlled trials(RCTs)of acupuncture and related therapies in the treatment of hyperlipidemia.The data were analyzed using Stata 15.0 and WinBUGS 1.4.3 software after two researchers independently screened the literature,extracted the data,and assessed the risk of bias in the included studies.Results We analyzed a total of 36 eligible studies that included 3124 patients,involving 12 types of acupuncture and related therapies and comprehensive therapies.The results of the NMA showed that:for the total cholesterol(TC),acupoint catgut embedding(ACE),simple acupuncture(ACU),acupoint injection(AI),electroacupuncture(EA),western medicine of statins(WM),and combination of acupuncture and related therapies(combined therapies)were all more effective than placebo(P<0.05).For triacylglycerol(TG),ACU,EA,warming acupuncture(WA),WM and combined therapies were better than placebo(P<0.05),while WA was better than Chinese herb(CH)(P<0.05).For low-density lipoprotein cholesterol(LDL-C),combined therapies were more effective than lifestyle modification(LM)(P<0.05).For high-density lipoprotein cholesterol(HDL-C),auricular acupoint stimulation(AAS),ACE,ACU,AI,CH,EA,LM,moxibustion(MOX),WM,combined therapies and placebo were all worse than WA(P<0.05),while WM and combined therapies were better than ACU(P<0.05).Combined ranking results suggest that ACU and combined therapies may be the optimal intervention.Conclusions The efficacy of all kinds of acupuncture-related therapies in patients with hyperlipidemia is better than lifestyle changes.However,for different outcome indicators,all kinds of acupuncture-related therapies have their advantages and disadvantages,and comprehensive ranking results suggest that ACU and combined therapies may be the optimal intervention.
文摘Objective: To observe the effect of acupuncture on simple obesity and cellular hemorheology. Methods: Thirty-two cases of simple obesity patients were enrolled into this study. Acupoints of the Stomach Meridian and Spleen Meridian as Zhongwan (中脘 CV 12), Liangmen (梁门 ST 21), Tianshu (天枢 ST 25), Guayuan (关元 CV 4), etc. were punctured, once daily in the first 5 days, and once every other day afterwards, with 10 sessions being a therapeutic course. Before treatment and after 3 courses of treatment, the body weight, waistline, weight index, seam cholesterol (CH), triglyceride and aggregation index of red blood cell (RBC) were detected. Results: After acupuncture treatment, all the indexes of body weight, waistline, weight index, serum CH, triglyceride and aggregation index of RBC decreased significantly in comparison with those of pre-treatment(P< 0.05). Conclusion: Acupuncture can apparently improve cellular hemorheology, reduce body weight, serum cholesterol and TG levels in simple obesity patients.
