Autophagy or self-digestion of cells is activated upon various stressful stimuli and has been found to be a survival and drug resistance pathway in cancer.However,genetic studies support that autophagy can act as a tu...Autophagy or self-digestion of cells is activated upon various stressful stimuli and has been found to be a survival and drug resistance pathway in cancer.However,genetic studies support that autophagy can act as a tumor suppressor.Furthermore,defective autophagy is implicated in tumorigenesis,as well.The precise impact of autophagy on malignant transformation has not yet been clarified,but recent data suggest that this complex process is mainly directed by cell types,phases,genetic background and microenvironment.Relation of autophagy to anticancer immune responses may indicate a novel aspect in cancer chemotherapy.展开更多
There are deep-rooted traditions of researches on the youth problems in Russia, By their trends and purposes they partly concur with the traditions of the humanities in Europe and America. In Russia in different times...There are deep-rooted traditions of researches on the youth problems in Russia, By their trends and purposes they partly concur with the traditions of the humanities in Europe and America. In Russia in different timesmit was the same way in the West-diverse youth concepts had been conveying and continue to express the society＇s expectations for new generations. This is in a sense a theoretical mirror of the natural process of generation change. Under modern conditions these concepts can be reduced to three directions： youth-＂no man＇s land＂, youth-social danger, youth-hope of society. At the same time youth theories have the mark of the socio-cultural contexts and contexts of the development of the humanities in Russia. In this article these similarities and distinctions will be examined.展开更多
In recent years, research emphasis in the field of SLA （second language acquisition） has shifted to the study of the learning process and behaviors of learners than that of teachers. Researches concerning the learn...In recent years, research emphasis in the field of SLA （second language acquisition） has shifted to the study of the learning process and behaviors of learners than that of teachers. Researches concerning the learners＇ language learning strategies and learning styles have been conducted in different cultural backgrounds. However, comparatively speaking, there are few studies focusing on the relationship between language learning strategies and learning style preferences in English learning among Chinese students. This paper elaborates on the research questions and hypotheses according to the English Learning Questionnaire, which consists primarily of SILL （Strategy Inventory for Language Learning） （Oxford, 1990） and PLSP （Perceptual Learning Style Preference） Survey （Reid, 1987） to identify their English learning strategy uses and learning style preferences. Then, with statistical analysis （by SPSS （Statistical Product and Service Solutions）） of the results of the questionnaire, discussions are made on the correlation between learning strategies, learning style preferences, and their gender differences, followed by pedagogical implications for English teaching and learning in the university settings in China.展开更多
With unique physical and chemical properties, aqueous solutions in the mantle may play important roles for a number of geochemical and geodynamical processes. However, since experimental data available are very limite...With unique physical and chemical properties, aqueous solutions in the mantle may play important roles for a number of geochemical and geodynamical processes. However, since experimental data available are very limited, people still know little about the aqueous solutions and their interactions with surrounding rocks and melts. From the perspective of thermodynamics, equation of state(EOS) is the key to push forward the modeling of aqueous solutions. Nevertheless, up to now accurate EOSs suitable for the mantle conditions are still in shortage. With discussions over several recognized EOSs, we summarize several ways to enhance the predictability of EOS: utilizing high quality data from molecular simulations, choosing functions with sound physical background, and improving the regression procedures for the empirical parameters. In the meantime, we find that the ion-bearing systems are still the focus of challenges in this area. New developments of experiments and computer simulations effectively deal with these challenges and in-depth understandings of aqueous solutions in the mantle are expected in the near future.展开更多
Tarim Large Igneous Province （TLIP） is the second Late Paleozoic LIPs in China after the recognition of Emeishan LIP, and is a hot research topic in geosciences. On the basis of the analysis of research history abou...Tarim Large Igneous Province （TLIP） is the second Late Paleozoic LIPs in China after the recognition of Emeishan LIP, and is a hot research topic in geosciences. On the basis of the analysis of research history about TLIP, this paper summarizes the re- search result during last twenty years and suggests the key research area in the future. The residual distribution range of TLIP is up to 250000 km2, and the largest residual thickness is 780 m. The eruption of basalt happened during 290-288 Ma and be- longs to LIPs magmatic event with fast eruption of magma. The lithological units of the TLIP include basalt, diabase, layered intrusive rock, breccia pipe mica-olivine pyroxenite, olivine pyroxenite, gabbro, ultramafic dyke, quartz syenite, quartz syenite porphyry and bimodal dyke. The basalt and diabase of TLIP exhibit OIB-like trace element patterns and enrichment of LILE and HFSE, and mainly belong to high TiO2 series. There is an obvious difference in isotope among the basalt from Keping and the basalt and dibase from the northern Tarim Basin. The basalt from Keping with negative eNa and high REE value derives from enriched mantle, and the diabase and basalt from the northern Tarim Basin with positive ENa and low REE value axe re- lated to depleted mantle. The crust uplifting in the Early Permian and the development of picrite and large scale dyke and for- mation of large scale V-Ti-Magnetite deposit in Wajilitag area support the view that the TLIP is related to mantle plume. The TLIP has a temporal-spatial relationship with Permian basic to ultra-basic igneous rock, which is distributed widely in Central Asia, and they represent a tectono-magmatic event with very important geodynamic setting. This paper also suggests that the deep geological process, the relation with mantle plume, mineralization, the relation with environmental change and biological evolution, and the geodynamics of the TLIP will be the key research topics in the future.展开更多
文摘Autophagy or self-digestion of cells is activated upon various stressful stimuli and has been found to be a survival and drug resistance pathway in cancer.However,genetic studies support that autophagy can act as a tumor suppressor.Furthermore,defective autophagy is implicated in tumorigenesis,as well.The precise impact of autophagy on malignant transformation has not yet been clarified,but recent data suggest that this complex process is mainly directed by cell types,phases,genetic background and microenvironment.Relation of autophagy to anticancer immune responses may indicate a novel aspect in cancer chemotherapy.
文摘There are deep-rooted traditions of researches on the youth problems in Russia, By their trends and purposes they partly concur with the traditions of the humanities in Europe and America. In Russia in different timesmit was the same way in the West-diverse youth concepts had been conveying and continue to express the society＇s expectations for new generations. This is in a sense a theoretical mirror of the natural process of generation change. Under modern conditions these concepts can be reduced to three directions： youth-＂no man＇s land＂, youth-social danger, youth-hope of society. At the same time youth theories have the mark of the socio-cultural contexts and contexts of the development of the humanities in Russia. In this article these similarities and distinctions will be examined.
文摘In recent years, research emphasis in the field of SLA （second language acquisition） has shifted to the study of the learning process and behaviors of learners than that of teachers. Researches concerning the learners＇ language learning strategies and learning styles have been conducted in different cultural backgrounds. However, comparatively speaking, there are few studies focusing on the relationship between language learning strategies and learning style preferences in English learning among Chinese students. This paper elaborates on the research questions and hypotheses according to the English Learning Questionnaire, which consists primarily of SILL （Strategy Inventory for Language Learning） （Oxford, 1990） and PLSP （Perceptual Learning Style Preference） Survey （Reid, 1987） to identify their English learning strategy uses and learning style preferences. Then, with statistical analysis （by SPSS （Statistical Product and Service Solutions）） of the results of the questionnaire, discussions are made on the correlation between learning strategies, learning style preferences, and their gender differences, followed by pedagogical implications for English teaching and learning in the university settings in China.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41590620 & 41473060)
文摘With unique physical and chemical properties, aqueous solutions in the mantle may play important roles for a number of geochemical and geodynamical processes. However, since experimental data available are very limited, people still know little about the aqueous solutions and their interactions with surrounding rocks and melts. From the perspective of thermodynamics, equation of state(EOS) is the key to push forward the modeling of aqueous solutions. Nevertheless, up to now accurate EOSs suitable for the mantle conditions are still in shortage. With discussions over several recognized EOSs, we summarize several ways to enhance the predictability of EOS: utilizing high quality data from molecular simulations, choosing functions with sound physical background, and improving the regression procedures for the empirical parameters. In the meantime, we find that the ion-bearing systems are still the focus of challenges in this area. New developments of experiments and computer simulations effectively deal with these challenges and in-depth understandings of aqueous solutions in the mantle are expected in the near future.
基金supported by the National Natural Science Foundation of China(Grant No.40930315)National Basic Research Program of China(Grant Nos.2007CB411303&2011CB808902)
文摘Tarim Large Igneous Province （TLIP） is the second Late Paleozoic LIPs in China after the recognition of Emeishan LIP, and is a hot research topic in geosciences. On the basis of the analysis of research history about TLIP, this paper summarizes the re- search result during last twenty years and suggests the key research area in the future. The residual distribution range of TLIP is up to 250000 km2, and the largest residual thickness is 780 m. The eruption of basalt happened during 290-288 Ma and be- longs to LIPs magmatic event with fast eruption of magma. The lithological units of the TLIP include basalt, diabase, layered intrusive rock, breccia pipe mica-olivine pyroxenite, olivine pyroxenite, gabbro, ultramafic dyke, quartz syenite, quartz syenite porphyry and bimodal dyke. The basalt and diabase of TLIP exhibit OIB-like trace element patterns and enrichment of LILE and HFSE, and mainly belong to high TiO2 series. There is an obvious difference in isotope among the basalt from Keping and the basalt and dibase from the northern Tarim Basin. The basalt from Keping with negative eNa and high REE value derives from enriched mantle, and the diabase and basalt from the northern Tarim Basin with positive ENa and low REE value axe re- lated to depleted mantle. The crust uplifting in the Early Permian and the development of picrite and large scale dyke and for- mation of large scale V-Ti-Magnetite deposit in Wajilitag area support the view that the TLIP is related to mantle plume. The TLIP has a temporal-spatial relationship with Permian basic to ultra-basic igneous rock, which is distributed widely in Central Asia, and they represent a tectono-magmatic event with very important geodynamic setting. This paper also suggests that the deep geological process, the relation with mantle plume, mineralization, the relation with environmental change and biological evolution, and the geodynamics of the TLIP will be the key research topics in the future.
