Both the Wnt/β-catenin and Bone morphogenetic protein （Bmp） signaling pathways play critical roles in dorsal-ventral patterning of the Xenopus embryos. The lymphoid enhancer binding factor （Lef） / T cell factor ...Both the Wnt/β-catenin and Bone morphogenetic protein （Bmp） signaling pathways play critical roles in dorsal-ventral patterning of the Xenopus embryos. The lymphoid enhancer binding factor （Lef） / T cell factor （Tcf） have been viewed as dedicated transcription factors of the Wnt/β-catenin signaling pathway that are activated by β-catenin binding. Now a Xenopus ventral specific transcription factor Xom has also been identified to bear transactivation activity by binding to Lef/Tcf factors [1].展开更多
文摘Both the Wnt/β-catenin and Bone morphogenetic protein （Bmp） signaling pathways play critical roles in dorsal-ventral patterning of the Xenopus embryos. The lymphoid enhancer binding factor （Lef） / T cell factor （Tcf） have been viewed as dedicated transcription factors of the Wnt/β-catenin signaling pathway that are activated by β-catenin binding. Now a Xenopus ventral specific transcription factor Xom has also been identified to bear transactivation activity by binding to Lef/Tcf factors [1].
