Objective: The increased perinatal morbidity in diabetes may be partly related to vascular dysfunction. Because potassium channels play an important role in the regulation of vascular tone, this study explores the imp...Objective: The increased perinatal morbidity in diabetes may be partly related to vascular dysfunction. Because potassium channels play an important role in the regulation of vascular tone, this study explores the impact of diabetes on potassium channel function in the fetoplacental vascular bed. Study design: Vascular potassium channel function was investigated by ex vivo dual perfusion of isolated placental cotyledons (n = 47). Appropriate control experiments were carried out to exclude nonspecific effects. Results: Glibenclamide (KATP channel blocker) increased perfusion pressure to a maximum fetoplacental arterial pressure of 37 ± .6 mm Hg in controls versus 15 ± 6 mm Hg in diabetes (P <. 05). 4- Aminopyridine (KV channel blocker) equally increased fetoplacental arterial pressure in controls, and in diabetes (21 ± 4 mm Hg vs 22 ± 2 mm Hg). Apamin and charybdotoxin (KCa channel blockers) caused a negligible rise in fetoplacental arterial pressure. Conclusion: In the fetoplacental circulation, KATP channels and KV channels significantly contribute to baseline vascular tone. In diabetes, vascular KATP channel function is impaired.展开更多
随着＂The fetus as a patient＂的理念发展,胎儿外科学成为一门迅速发展的学科,紧随国际胎儿医学的进展,国内多家大型医疗机构已先后开展胎儿外科手术。胎儿手术包括产时胎儿手术（IFO）、开放式宫内手术及胎儿镜微创手术。其中IFO包...随着＂The fetus as a patient＂的理念发展,胎儿外科学成为一门迅速发展的学科,紧随国际胎儿医学的进展,国内多家大型医疗机构已先后开展胎儿外科手术。胎儿手术包括产时胎儿手术（IFO）、开放式宫内手术及胎儿镜微创手术。其中IFO包括胎盘支持的产时胎儿手术（OOPS）,即维持胎儿胎盘循环状态下进行胎儿疾病的矫治手术;子宫外产时处理（EXIT）,展开更多
文摘Objective: The increased perinatal morbidity in diabetes may be partly related to vascular dysfunction. Because potassium channels play an important role in the regulation of vascular tone, this study explores the impact of diabetes on potassium channel function in the fetoplacental vascular bed. Study design: Vascular potassium channel function was investigated by ex vivo dual perfusion of isolated placental cotyledons (n = 47). Appropriate control experiments were carried out to exclude nonspecific effects. Results: Glibenclamide (KATP channel blocker) increased perfusion pressure to a maximum fetoplacental arterial pressure of 37 ± .6 mm Hg in controls versus 15 ± 6 mm Hg in diabetes (P <. 05). 4- Aminopyridine (KV channel blocker) equally increased fetoplacental arterial pressure in controls, and in diabetes (21 ± 4 mm Hg vs 22 ± 2 mm Hg). Apamin and charybdotoxin (KCa channel blockers) caused a negligible rise in fetoplacental arterial pressure. Conclusion: In the fetoplacental circulation, KATP channels and KV channels significantly contribute to baseline vascular tone. In diabetes, vascular KATP channel function is impaired.
文摘随着＂The fetus as a patient＂的理念发展,胎儿外科学成为一门迅速发展的学科,紧随国际胎儿医学的进展,国内多家大型医疗机构已先后开展胎儿外科手术。胎儿手术包括产时胎儿手术（IFO）、开放式宫内手术及胎儿镜微创手术。其中IFO包括胎盘支持的产时胎儿手术（OOPS）,即维持胎儿胎盘循环状态下进行胎儿疾病的矫治手术;子宫外产时处理（EXIT）,
