Fetal cardiac operation has been done in sheep so a method to protect the fetal and placenta after cessation of bypass is important.This is to review the progress in research of fetal cardiac bypass and prevention of ...Fetal cardiac operation has been done in sheep so a method to protect the fetal and placenta after cessation of bypass is important.This is to review the progress in research of fetal cardiac bypass and prevention of placental dysfunction.The placental dysfunction results from different factors such as distribution of blood flow,stress response,placental perfusion, hypothermia and higher pressure oxygen.Observations were made in fetal Cardiac Bypass.Administration of high dose of sodium nitropusside,the indomethacin,total spinal anesthetic to block the fetal stress response and the improvement the equipment of the cardiopulmonary bypass devices and the normotherimia with high flow can maintain the placental function.Currently informationindicates thatintrauterine correction of selected congenital cardiac defects will be available in human fetuses in notremote future.展开更多
目的:探讨基于母胎血清胆汁酸代谢轮廓的妊娠肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)分度。方法:采用高效液相色谱-紫外检测法对61名正常孕妇,轻、重度ICP患者母、脐血的9种结合型胆汁酸成分进行测定,并将受试者分...目的:探讨基于母胎血清胆汁酸代谢轮廓的妊娠肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)分度。方法:采用高效液相色谱-紫外检测法对61名正常孕妇,轻、重度ICP患者母、脐血的9种结合型胆汁酸成分进行测定,并将受试者分为建模集(n=40)与验证集(n=21),结合偏最小二乘判别分析对胆汁酸代谢轮廓进行分析、建模与验证。结果:母血胆汁酸代谢模型可区分正常孕妇组,轻度ICP组,与重度ICP组;脐血胆汁酸代谢模型可区分重度ICP组与非重度组。母、脐血分度模型的验证效率分别达90.5%与100.0%。牛磺熊去氧胆酸(P=0.004),牛磺胆酸(P=0.005)以及甘氨胆酸(P=0.032)在ICP孕妇中明显增高;甘氨石胆酸(P<0.001)和牛磺脱氧胆酸(P=0.001)在ICP胎儿中明显增高。结论:ICP母、脐血各有其特征的胆汁酸代谢轮廓,均可用于对ICP分度。展开更多
文摘Fetal cardiac operation has been done in sheep so a method to protect the fetal and placenta after cessation of bypass is important.This is to review the progress in research of fetal cardiac bypass and prevention of placental dysfunction.The placental dysfunction results from different factors such as distribution of blood flow,stress response,placental perfusion, hypothermia and higher pressure oxygen.Observations were made in fetal Cardiac Bypass.Administration of high dose of sodium nitropusside,the indomethacin,total spinal anesthetic to block the fetal stress response and the improvement the equipment of the cardiopulmonary bypass devices and the normotherimia with high flow can maintain the placental function.Currently informationindicates thatintrauterine correction of selected congenital cardiac defects will be available in human fetuses in notremote future.
文摘目的:探讨基于母胎血清胆汁酸代谢轮廓的妊娠肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)分度。方法:采用高效液相色谱-紫外检测法对61名正常孕妇,轻、重度ICP患者母、脐血的9种结合型胆汁酸成分进行测定,并将受试者分为建模集(n=40)与验证集(n=21),结合偏最小二乘判别分析对胆汁酸代谢轮廓进行分析、建模与验证。结果:母血胆汁酸代谢模型可区分正常孕妇组,轻度ICP组,与重度ICP组;脐血胆汁酸代谢模型可区分重度ICP组与非重度组。母、脐血分度模型的验证效率分别达90.5%与100.0%。牛磺熊去氧胆酸(P=0.004),牛磺胆酸(P=0.005)以及甘氨胆酸(P=0.032)在ICP孕妇中明显增高;甘氨石胆酸(P<0.001)和牛磺脱氧胆酸(P=0.001)在ICP胎儿中明显增高。结论:ICP母、脐血各有其特征的胆汁酸代谢轮廓,均可用于对ICP分度。
