Mammalian cortical development is a dynamically and strictly regulated process orchestrated by extracellular signals and intracellular mechanisms. Recent studies show that epigenetic regulation serves as, at least in ...Mammalian cortical development is a dynamically and strictly regulated process orchestrated by extracellular signals and intracellular mechanisms. Recent studies show that epigenetic regulation serves as, at least in part, interfaces between genes and the environment, and also provides insight into the molecular and cellular bases of early embryonic cortical development. It is becoming increasingly clear that epigenetic regulation of cortical development occurs at multiple levels and that comprehensive knowledge of this complex regulatory landscape is essential to delineating embryonic neurogenesis.展开更多
基金supported by the Chinese Ministry of Science and Technology(2015CB964501 and2014CB964903)the National Natural Science Foundation of China(31371477)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01020301)
文摘Mammalian cortical development is a dynamically and strictly regulated process orchestrated by extracellular signals and intracellular mechanisms. Recent studies show that epigenetic regulation serves as, at least in part, interfaces between genes and the environment, and also provides insight into the molecular and cellular bases of early embryonic cortical development. It is becoming increasingly clear that epigenetic regulation of cortical development occurs at multiple levels and that comprehensive knowledge of this complex regulatory landscape is essential to delineating embryonic neurogenesis.
