目的:探讨不同胚胎移植管对体外受精-胚胎移植技术妊娠结局的影响。方法:2015年5月-2017年8月收治接受体外受精-胚胎移植技术不孕患者100例,随机分为两组,各50例。观察组接受Cook Sydney IVF移植管移植;对照组接受Frydman CD管移植。对...目的:探讨不同胚胎移植管对体外受精-胚胎移植技术妊娠结局的影响。方法:2015年5月-2017年8月收治接受体外受精-胚胎移植技术不孕患者100例,随机分为两组,各50例。观察组接受Cook Sydney IVF移植管移植;对照组接受Frydman CD管移植。对比两组妊娠结局,评价不同胚胎移植管对新鲜体外受精-胚胎移植技术妊娠结局的影响。结果:观察组胚胎种植率、临床妊娠率、继续妊娠率均显著高于对照组,差异有统计学意义(P<0.05);观察组早期自然流产率显著低于对照组,差异有统计学意义(P<0.05)。结论:进行体外受精-胚胎移植时,使用Cook Sydney IVF移植管移植效果优于Frydman CD管移植,可进一步提高孕产妇正常妊娠率、降低不良妊娠事件发生率。展开更多
To assess the impact of cannulation of a resistant cervical os with the outer malleable sheath of a doublelumen, soft ET catheter on IVFET outcomes. Retrospective cohort study. Universitybased IVF center. One hund...To assess the impact of cannulation of a resistant cervical os with the outer malleable sheath of a doublelumen, soft ET catheter on IVFET outcomes. Retrospective cohort study. Universitybased IVF center. One hundred fortytwo patients undergoing 142 ETs. Trial ultrasoundguided ET at all transfers, leaving the malleable outer sheath in situ when the soft inner catheter could not negotiate the internal os. Implantation rate and clinical pregnancy rate. In 102 ETs (71.8%), the soft inner sheath easily negotiated the internal os (group 1). Forty ETs (28.2%)required cannulation of resistant internal ora with the outer sheath of the trial catheter (group 2). Implantation rates (35%vs. 32%in groups 1 and 2, respectively) and clinical pregnancy rates (50%vs. 45%) were not significantly different between groups. Blood was present on the transfer catheter after ET more frequently in group 2 than in group 1 (55%vs. 15%); however, neither the implantation rate nor the clinical pregnancy rate were affected by the presence of blood. Cannulation of a resistant internal os by the malleable outer sheath and blood on the transfer catheter after ET do not have an adverse effect on implantation rate or clinical pregnancy rate.展开更多
目的:比较决策树和Logistic回归模型对体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)患者妊娠结局的预测价值。方法:纳入2021年1月至2022年10月在长治医学院附属和平医院接受IVF-ET的患者350例为研究对象,根...目的:比较决策树和Logistic回归模型对体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)患者妊娠结局的预测价值。方法:纳入2021年1月至2022年10月在长治医学院附属和平医院接受IVF-ET的患者350例为研究对象,根据妊娠结局分为妊娠成功组(215例)和妊娠失败组(135例)。收集患者临床资料,建立IVF-ET患者妊娠结局Logistic回归和决策树预测模型,并在是否基于Logistic回归结果条件下建立决策树分析模型(决策树1和决策树2),采用受试者工作特征(receiver operating characteristic,ROC)曲线对模型预测效果进行评价。结果:350例患者中,妊娠成功患者占61.43%,妊娠失败者占38.57%。妊娠失败组年龄≥35岁、不孕年限≥5年、周期次数≥1次、有心理精神障碍的患者比例及HCG日血清孕酮水平均高于妊娠成功组,获卵数≥10枚、受精率≥75%的患者比例及HCG日子宫内膜厚度、优质胚胎数小于妊娠成功组(P<0.05)。多因素Logistic回归分析结果显示,年龄、HCG日血清孕酮水平、优质胚胎数及心理精神障碍均是IVF-ET患者妊娠结局的影响因素(P<0.05)。决策树模型显示,年龄、HCG日血清孕酮水平、优质胚胎数为IVF-ET患者妊娠结局的影响因素。Logistic回归模型曲线下面积(area under curve,AUC)为0.832,预测敏感度、特异度和准确度分别为87.3%、71.4%、83.5%;决策树1的AUC为0.859,预测敏感度、特异度和准确度分别为85.1%、76.8%、85.6%;决策树2的AUC为0.820,预测敏感度、特异度和准确度分别为83.7%、73.2%、82.4%。决策树1的AUC大于决策树2(P<0.05),但与Logistic回归模型的AUC比较差异无统计学意义(P>0.05)。结论:Logistic回归模型和决策树模型对于IVF-ET患者妊娠结局均有一定的预测价值。展开更多
文摘目的:探讨不同胚胎移植管对体外受精-胚胎移植技术妊娠结局的影响。方法:2015年5月-2017年8月收治接受体外受精-胚胎移植技术不孕患者100例,随机分为两组,各50例。观察组接受Cook Sydney IVF移植管移植;对照组接受Frydman CD管移植。对比两组妊娠结局,评价不同胚胎移植管对新鲜体外受精-胚胎移植技术妊娠结局的影响。结果:观察组胚胎种植率、临床妊娠率、继续妊娠率均显著高于对照组,差异有统计学意义(P<0.05);观察组早期自然流产率显著低于对照组,差异有统计学意义(P<0.05)。结论:进行体外受精-胚胎移植时,使用Cook Sydney IVF移植管移植效果优于Frydman CD管移植,可进一步提高孕产妇正常妊娠率、降低不良妊娠事件发生率。
文摘To assess the impact of cannulation of a resistant cervical os with the outer malleable sheath of a doublelumen, soft ET catheter on IVFET outcomes. Retrospective cohort study. Universitybased IVF center. One hundred fortytwo patients undergoing 142 ETs. Trial ultrasoundguided ET at all transfers, leaving the malleable outer sheath in situ when the soft inner catheter could not negotiate the internal os. Implantation rate and clinical pregnancy rate. In 102 ETs (71.8%), the soft inner sheath easily negotiated the internal os (group 1). Forty ETs (28.2%)required cannulation of resistant internal ora with the outer sheath of the trial catheter (group 2). Implantation rates (35%vs. 32%in groups 1 and 2, respectively) and clinical pregnancy rates (50%vs. 45%) were not significantly different between groups. Blood was present on the transfer catheter after ET more frequently in group 2 than in group 1 (55%vs. 15%); however, neither the implantation rate nor the clinical pregnancy rate were affected by the presence of blood. Cannulation of a resistant internal os by the malleable outer sheath and blood on the transfer catheter after ET do not have an adverse effect on implantation rate or clinical pregnancy rate.
文摘目的:比较决策树和Logistic回归模型对体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)患者妊娠结局的预测价值。方法:纳入2021年1月至2022年10月在长治医学院附属和平医院接受IVF-ET的患者350例为研究对象,根据妊娠结局分为妊娠成功组(215例)和妊娠失败组(135例)。收集患者临床资料,建立IVF-ET患者妊娠结局Logistic回归和决策树预测模型,并在是否基于Logistic回归结果条件下建立决策树分析模型(决策树1和决策树2),采用受试者工作特征(receiver operating characteristic,ROC)曲线对模型预测效果进行评价。结果:350例患者中,妊娠成功患者占61.43%,妊娠失败者占38.57%。妊娠失败组年龄≥35岁、不孕年限≥5年、周期次数≥1次、有心理精神障碍的患者比例及HCG日血清孕酮水平均高于妊娠成功组,获卵数≥10枚、受精率≥75%的患者比例及HCG日子宫内膜厚度、优质胚胎数小于妊娠成功组(P<0.05)。多因素Logistic回归分析结果显示,年龄、HCG日血清孕酮水平、优质胚胎数及心理精神障碍均是IVF-ET患者妊娠结局的影响因素(P<0.05)。决策树模型显示,年龄、HCG日血清孕酮水平、优质胚胎数为IVF-ET患者妊娠结局的影响因素。Logistic回归模型曲线下面积(area under curve,AUC)为0.832,预测敏感度、特异度和准确度分别为87.3%、71.4%、83.5%;决策树1的AUC为0.859,预测敏感度、特异度和准确度分别为85.1%、76.8%、85.6%;决策树2的AUC为0.820,预测敏感度、特异度和准确度分别为83.7%、73.2%、82.4%。决策树1的AUC大于决策树2(P<0.05),但与Logistic回归模型的AUC比较差异无统计学意义(P>0.05)。结论:Logistic回归模型和决策树模型对于IVF-ET患者妊娠结局均有一定的预测价值。
