AIM： To study the relationship between the cytotoxinassociated gene-A （CagA） status of H pylori strains and cerebral infarction among European Caucasians and Chinese Han by conducting a meta-analysis.METHODS： Ten ...AIM： To study the relationship between the cytotoxinassociated gene-A （CagA） status of H pylori strains and cerebral infarction among European Caucasians and Chinese Han by conducting a meta-analysis.METHODS： Ten case-control studies, with data on a total of 907 cases and 966 controls, were retrieved and considered; disqualified studies were excluded. The included studies were then tested for heterogeneity, and a meta-analysis was performed.RESULTS： The combined data revealed CagA-bearing strains of Hpylori which cause chronic infection are associated with an increased risk of cerebral infarction （OR = 2.66, 950 CI： 2.17-3.26）, but no such relationship was found with CagA-negative strains （OR = 0.74, 95% CI： 0.49-1.10） in the overall population. We performed subgroup analyses, dividing the overall population into European Caucasians and Chinese Han subgroups, and analyzed the studies according to their subgroup classification. Through the subgroup analysis, an association between cerebral infarction and CagAbearing strains was found in both subgroups （OR = 2.60, 95% CI： 1.93-3.49 in Chinese Han; OR = 2.71, 95% CI： 2.05-3.59 in European Caucasians）, but no significant association was found between cerebral infarction and CagA-negative strains （OR = 0.81, 95% CI： 0.45-1.48 in Chinese Han; OR = 0.64, 95% CI： 0.37-1.09 in European Caucasians）.CONCLUSION： These results suggest CagA-bearing strains of H pylori are significantly associated with susceptibility to cerebral infarction in Chinese Han and European Caucasians, but that CagA-negative strains are not a definite predisposing factor in either subgroup. The magnitude of this association with cerebral infarction needs to be confirmed by prospective studies and combined studies of Hpylori eradication.展开更多
Background Large-scale clinical research on the relationship between red blood cell distribution width （RDW） and intermediate-term prognosis in elderly patients with coronary artery disease （CAD） is lacking. Thus,...Background Large-scale clinical research on the relationship between red blood cell distribution width （RDW） and intermediate-term prognosis in elderly patients with coronary artery disease （CAD） is lacking. Thus, this study investigated the effects of RDW on the intermediate-term mortality of elderly patients who underwent elective percutaneous coronary intervention （PCI）. Methods Data from 1891 patients 〉 65 years old underwent elective PCI from July 2009 to September 2011 were collected. Based on preoperative median RDW （12.3%）, the patients were divided into two groups. The low RDW group （RDW 〈 12.3%） had 899 cases; the high RDW group （RDW 〉 12.3%） had 992 cases. The all-cause mortality rates of the two groups were compared. Results Patients in the high RDW group were more likely to be female and accompanied with diabetes, had lower hemoglobin level. The mean follow-up period was 527 days. During follow-up, 61 patients died （3.2%）. The postoperative mortality of the high RDW group was significantly higher than that of the low RDW group （4.3% vs. 2.0%, P = 0.004）. After adjusting other factors, multivariate Cox regression analysis revealed that preoperative high RDW was significantly associated with postoperative all-cause mortality （hazard ratio： 2.301, 95% confidence interval： 1.106-4.785, P = 0.026）. Conclusions Increased RDW was an independent predictor of the increased intermediate-term all-cause mortality in elderly CAD patients after elective PCI.展开更多
A new Shift bases was synthesized by the reaction of p-dimetyl-amino-benzylaldehide and α-naftyl-amine. All synthesized compounds were characterized by elemental analysis, IR （infra red） spectroscopy and NMR （nucl...A new Shift bases was synthesized by the reaction of p-dimetyl-amino-benzylaldehide and α-naftyl-amine. All synthesized compounds were characterized by elemental analysis, IR （infra red） spectroscopy and NMR （nuclear magnetic resonance） spectroscopy and evaluated for their in vitro antifungal activities of the compounds tested against Pseudomonas aeruginosa, Mycobacterium lacticolium, Aspergillus niger, Cladasporium resinale, Penicillium chrosegenum, Chastorniurn gloloodium and Trichoderma virideh. These derivatives have vast range of biological activities which benefit us.展开更多
Coronary stents are metal coils or mesh tubes delivered to blocked vessels through catheters, whic Recently, special drugs h are expanded by balloons to reopen and scaffold target vessels. are carried by stents （drug...Coronary stents are metal coils or mesh tubes delivered to blocked vessels through catheters, whic Recently, special drugs h are expanded by balloons to reopen and scaffold target vessels. are carried by stents （drug-eluting stents） to further reduce instent restenosis rate after stenting procedure. However, continual study on biomechanical characteristics of stents is necessary provide a more suitable drug loading for better interactions between stents and tissue, or to platform for drug-eluting stents. The purpose of this paper is to show how finite element methods can be used to study cell area and strut distribution changes of bent coronary stents. A same bending deformation was applied to two commercial coronary stent models by a rigid curved vessel. Results show that the stent design influenced the changes of cell area and strut distribution under bending situation. The stent with links had more cell area changes at outer curvature, and the stent with peak-peak （ 〉 〈 ） strut design could have strut contact and overlapping at inner curvature. In conclusion, this finite element method can be used to study and compare cell area and strut distribution changes of bent stents, and to provide a convenient tool for designers in testing and improving biomechanical characteristics of new stents.展开更多
Micropipette aspiration(MA) is widely applied in cell mechanics, however, at small deformations a common model corresponding to the MA is the half-space model wherein the finite cell size and cell compressibility are ...Micropipette aspiration(MA) is widely applied in cell mechanics, however, at small deformations a common model corresponding to the MA is the half-space model wherein the finite cell size and cell compressibility are neglected. This study extends the half-space model by accounting for the influence of cell geometry and compressibility(sphere model). Using a finite element analysis of cell aspiration into a micropipette, an elastic approximation formula of the aspirated length was derived for the sphere model. The approximation formula includes the geometry parameter of the sphere model(ζ = R/a, R is the radius of the cell, and a is the inner radius of the micropipette) and the Poisson's ratio v of the cell. The results indicate that the parameter and Poisson's ratio v markedly affect the aspirated length, particularly for small and v. When ζ→∞ and v→0.5,the approximation formula tends to the analytical solution for the half-space model. In the incompressible case(v = 0.5), within the general experimental range(ζ varying from 2 to 4), the difference between the analytical solution and the approximate one is significant, and is up to 29% of the approximation solution when ζ= 2. Additionally, parametere was introduced to evaluate the error of elastic moduli between the half-space model and sphere model. Based on the approximation formula, the ζ thresholds, beyond which e becomes larger than 10% and 20%, were derived.展开更多
文摘AIM： To study the relationship between the cytotoxinassociated gene-A （CagA） status of H pylori strains and cerebral infarction among European Caucasians and Chinese Han by conducting a meta-analysis.METHODS： Ten case-control studies, with data on a total of 907 cases and 966 controls, were retrieved and considered; disqualified studies were excluded. The included studies were then tested for heterogeneity, and a meta-analysis was performed.RESULTS： The combined data revealed CagA-bearing strains of Hpylori which cause chronic infection are associated with an increased risk of cerebral infarction （OR = 2.66, 950 CI： 2.17-3.26）, but no such relationship was found with CagA-negative strains （OR = 0.74, 95% CI： 0.49-1.10） in the overall population. We performed subgroup analyses, dividing the overall population into European Caucasians and Chinese Han subgroups, and analyzed the studies according to their subgroup classification. Through the subgroup analysis, an association between cerebral infarction and CagAbearing strains was found in both subgroups （OR = 2.60, 95% CI： 1.93-3.49 in Chinese Han; OR = 2.71, 95% CI： 2.05-3.59 in European Caucasians）, but no significant association was found between cerebral infarction and CagA-negative strains （OR = 0.81, 95% CI： 0.45-1.48 in Chinese Han; OR = 0.64, 95% CI： 0.37-1.09 in European Caucasians）.CONCLUSION： These results suggest CagA-bearing strains of H pylori are significantly associated with susceptibility to cerebral infarction in Chinese Han and European Caucasians, but that CagA-negative strains are not a definite predisposing factor in either subgroup. The magnitude of this association with cerebral infarction needs to be confirmed by prospective studies and combined studies of Hpylori eradication.
文摘Background Large-scale clinical research on the relationship between red blood cell distribution width （RDW） and intermediate-term prognosis in elderly patients with coronary artery disease （CAD） is lacking. Thus, this study investigated the effects of RDW on the intermediate-term mortality of elderly patients who underwent elective percutaneous coronary intervention （PCI）. Methods Data from 1891 patients 〉 65 years old underwent elective PCI from July 2009 to September 2011 were collected. Based on preoperative median RDW （12.3%）, the patients were divided into two groups. The low RDW group （RDW 〈 12.3%） had 899 cases; the high RDW group （RDW 〉 12.3%） had 992 cases. The all-cause mortality rates of the two groups were compared. Results Patients in the high RDW group were more likely to be female and accompanied with diabetes, had lower hemoglobin level. The mean follow-up period was 527 days. During follow-up, 61 patients died （3.2%）. The postoperative mortality of the high RDW group was significantly higher than that of the low RDW group （4.3% vs. 2.0%, P = 0.004）. After adjusting other factors, multivariate Cox regression analysis revealed that preoperative high RDW was significantly associated with postoperative all-cause mortality （hazard ratio： 2.301, 95% confidence interval： 1.106-4.785, P = 0.026）. Conclusions Increased RDW was an independent predictor of the increased intermediate-term all-cause mortality in elderly CAD patients after elective PCI.
文摘A new Shift bases was synthesized by the reaction of p-dimetyl-amino-benzylaldehide and α-naftyl-amine. All synthesized compounds were characterized by elemental analysis, IR （infra red） spectroscopy and NMR （nuclear magnetic resonance） spectroscopy and evaluated for their in vitro antifungal activities of the compounds tested against Pseudomonas aeruginosa, Mycobacterium lacticolium, Aspergillus niger, Cladasporium resinale, Penicillium chrosegenum, Chastorniurn gloloodium and Trichoderma virideh. These derivatives have vast range of biological activities which benefit us.
文摘Coronary stents are metal coils or mesh tubes delivered to blocked vessels through catheters, whic Recently, special drugs h are expanded by balloons to reopen and scaffold target vessels. are carried by stents （drug-eluting stents） to further reduce instent restenosis rate after stenting procedure. However, continual study on biomechanical characteristics of stents is necessary provide a more suitable drug loading for better interactions between stents and tissue, or to platform for drug-eluting stents. The purpose of this paper is to show how finite element methods can be used to study cell area and strut distribution changes of bent coronary stents. A same bending deformation was applied to two commercial coronary stent models by a rigid curved vessel. Results show that the stent design influenced the changes of cell area and strut distribution under bending situation. The stent with links had more cell area changes at outer curvature, and the stent with peak-peak （ 〉 〈 ） strut design could have strut contact and overlapping at inner curvature. In conclusion, this finite element method can be used to study and compare cell area and strut distribution changes of bent stents, and to provide a convenient tool for designers in testing and improving biomechanical characteristics of new stents.
基金supported by the National Natural Science Foundation of China(Grant No.11032008)the Youth Fund of Taiyuan University of Technology
文摘Micropipette aspiration(MA) is widely applied in cell mechanics, however, at small deformations a common model corresponding to the MA is the half-space model wherein the finite cell size and cell compressibility are neglected. This study extends the half-space model by accounting for the influence of cell geometry and compressibility(sphere model). Using a finite element analysis of cell aspiration into a micropipette, an elastic approximation formula of the aspirated length was derived for the sphere model. The approximation formula includes the geometry parameter of the sphere model(ζ = R/a, R is the radius of the cell, and a is the inner radius of the micropipette) and the Poisson's ratio v of the cell. The results indicate that the parameter and Poisson's ratio v markedly affect the aspirated length, particularly for small and v. When ζ→∞ and v→0.5,the approximation formula tends to the analytical solution for the half-space model. In the incompressible case(v = 0.5), within the general experimental range(ζ varying from 2 to 4), the difference between the analytical solution and the approximate one is significant, and is up to 29% of the approximation solution when ζ= 2. Additionally, parametere was introduced to evaluate the error of elastic moduli between the half-space model and sphere model. Based on the approximation formula, the ζ thresholds, beyond which e becomes larger than 10% and 20%, were derived.
