Nitro and halogen substituted derivatives of the juglone naphthoquinone were synthesized and assayed for their antibacterial activity. 8-Nitrojuglone was obtained as the exclusive product from the direct nitration of ...Nitro and halogen substituted derivatives of the juglone naphthoquinone were synthesized and assayed for their antibacterial activity. 8-Nitrojuglone was obtained as the exclusive product from the direct nitration of juglone with nickel （Ⅱ） nitrate and p-toluenesulphonic acid. In addition, a series of five 8-halojuglone derivatives were synthesized via a solvent-free Friedel-Crafts acylation reaction. One of the acylation reactions afforded an anthraquinone-type derivative as the minor product. The 8-nitrojuglone derivative displayed the most notable activity against S. aureus. However, all of the 8-halojuglone derivatives were found to be less active than juglone against the bacteria assayed.展开更多
Painful swelling of the yang-heat type can be seen in many kinds of yang-heat syndromes of surgery, gynecology and pediatrics, and in some complications of internal medicine. Since 1987, we have successfully treated 2...Painful swelling of the yang-heat type can be seen in many kinds of yang-heat syndromes of surgery, gynecology and pediatrics, and in some complications of internal medicine. Since 1987, we have successfully treated 228 cases of different painful swelling syndromes of the yang-heat type by compress with Xiao Zhong San (消肿散), which was developed through repeated scanning on the basis of an ancient prescription of Tiao Wei Cheng Qi Tang (调胃承气汤) described in Treatise on Febrile Diseases written by Zhang Zhongjing. This is reported as follows.展开更多
文摘Nitro and halogen substituted derivatives of the juglone naphthoquinone were synthesized and assayed for their antibacterial activity. 8-Nitrojuglone was obtained as the exclusive product from the direct nitration of juglone with nickel （Ⅱ） nitrate and p-toluenesulphonic acid. In addition, a series of five 8-halojuglone derivatives were synthesized via a solvent-free Friedel-Crafts acylation reaction. One of the acylation reactions afforded an anthraquinone-type derivative as the minor product. The 8-nitrojuglone derivative displayed the most notable activity against S. aureus. However, all of the 8-halojuglone derivatives were found to be less active than juglone against the bacteria assayed.
文摘Painful swelling of the yang-heat type can be seen in many kinds of yang-heat syndromes of surgery, gynecology and pediatrics, and in some complications of internal medicine. Since 1987, we have successfully treated 228 cases of different painful swelling syndromes of the yang-heat type by compress with Xiao Zhong San (消肿散), which was developed through repeated scanning on the basis of an ancient prescription of Tiao Wei Cheng Qi Tang (调胃承气汤) described in Treatise on Febrile Diseases written by Zhang Zhongjing. This is reported as follows.
