2型糖尿病患者血清胰高血糖素样肽-1水平与认知功能障碍的相关性研究

目的分析2型糖尿病患者血清胰高血糖素样肽-1(GLP-1)水平与认知功能障碍的相关性。方法 选择新疆医科大学第二附属医院2020年2月~2022年2月接诊的148例2型糖尿病患者,根据简易精神状态评价量表(MMSE)评分进行分组,其中认知功能正常组(81例,MMSE评分≥27分)和认知功能障碍组(67例,MMSE评分<27分)。检测两组血清GLP-1水平,同时测定血脂、血糖代谢指标。比较两组一般资料、生化指标及血清GLP-1水平,使用Pearson相关性、多因素logistic回归和受试者工作特征曲线(ROC)分析GLP-1与认知功能障碍的关系。结果 认知功能障碍组体质量指数、胰岛素抵抗数(HOMA-IR)均大于认知功能正常组,空腹血糖(FBG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)水平、MMSE评分均高于认知功能正常组,血清GLP-1水平低于认知功能正常组,差异均有统计学意义(P <0.05);经Pearson相关性分析,2型糖尿病患者血清GLP-1水平与HbA1c、HOMA-IR呈负相关(r=-0.561、-0.571,P=0.000),与MMSE评分呈正相关(r=0.429,P=0.000);经多因素Logistic回归分析,HbA1c、HOMA-IR和血清GLP-1均是2型糖尿病患者发生认知功能障碍的独立影响因素(P <0.05);经受试者工作特征曲线(ROC)分析,血清GLP-1诊断2型糖尿病患者合并认知功能障碍的ROC曲线下面积(AUC)为0.910。结论 2型糖尿病患者合并认知功能障碍可能与血清GLP-1水平降低有关,值得临床予以重视。

脑心通胶囊对老年高血压伴糖尿病患者左室肥厚的影响

目的：探讨脑心通胶囊对老年高血压伴糖尿病患者空腹血糖、血清胰岛素、胰岛素抵抗指数及左室肥厚的影响。方法：病例90例，随机分为脑心通胶囊（口服3粒，tid）组，培哚普利（口服4～8mg·d^-1）组和非洛地平缓释片（口服6～8mg·d^-1）组，每组30例，均治疗12个月。治疗前、后检测空腹血糖、血清胰岛素、胰岛素抵抗指数及超声心动图，对比分析治疗前后上述指标的差异。结果：（1）与治疗前比较，3组治疗后收缩压和舒张压明显下降（P〈0．05），治疗后3组间比较收缩压及舒张压差异无显著性（P〉0．05）；（2）脑心通胶囊治疗后空腹血糖、胰岛素、胰岛素抵抗指数，左室后壁与室间隔厚度均明显下降（P〈0．05），左室质量与左室质量指数下降更显著（P〈0．01）；（3）培哚普利治疗后空腹血糖无明显改变，血清胰岛素水平及胰岛素抵抗指数有明显下降（P〈0．05），左室后壁与室间隔厚度无明显变化，左室质量及左室质量指数下降显著（P〈0．05）；（4）非洛地平缓释片治疗后左室质量及左室质量指数下降显著（P〈0．05），其他指标均无变化；（5）治疗后A、B两组比较空腹血糖、血清胰岛素水平及胰岛素抵抗指数、左室后壁与室间隔厚度，左室质量及左室质量指数下降差异均有显著性（P〈0．05）。结论：脑心通胶囊在提高胰岛素的敏感性、改善糖代谢的同时，使老年高血压伴糖尿病患者左室肥厚显著逆转，可预防心血管疾病的发生，值得进一步研究。

36例肝源性糖尿病的护理体会

肝脏是葡萄糖代谢的重要器官，各种原因导致的慢性肝脏损伤，往往影响正常的糖代谢，甚至发生糖耐量减退或糖尿病，这种继发于慢性肝实质损害的糖尿病，称为肝源性糖尿病。多数患者首先有肝病症状继而出现糖尿病症状，而无糖尿病的既往史和家族史，少数亦可同时出现。目前认为肝硬化时与糖代谢有关的酶多数活性降低以及肝细胞膜上胰岛素受体数量减少，均与肝源性糖尿病发生有关。随着肝病病情的好转，糖尿病症状亦消失。2007年2月-2008年2月，

Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis

AIM： TO evaluate insulin resistance, cytolysis and nonalcoholic steatohepatitis （NASH） score （NAS） using the Kleiner and Brunt criteria in 54 patients with NASH and mild-to-moderate hypertension, treated with telmisartan vs valsartan for 20 mo. METHODS： All patients met the NCEP-ATP Ⅲ criteria for metabolic syndrome. Histology confirmed steatohepatitis, defined as a NAS greater than five up to 3 wk prior inclusion, using the current criteria. Patients with viral hepatitis, chronic alcohol intake, drug abuse or other significant immune or metabolic hepatic pathology were excluded. Subjects were randomly assigned either to the valsartan （V） group （standard dose 80 mg o.d., n = 26）, or to the telmisartan （T） group （standard dose 20 mg o.d., n = 28）. Treatment had to be taken daily at the same hour with no concomitant medication or alcohol consumption allowed. Neither the patient nor the medical staff was aware of treatment group allocation. Paired liver biopsies obtained at inclusion （visit 1） and end of treatment （EOT） were assessed by a single blinded pathologist, not aware of patient or treatment group. Blood pressure, BMI, ALT, AST, HOMA-IR, plasma triglycerides （TG） and total cholesterol （TC） were evaluated at inclusion and every 4 mo until EOT （visit 6）. RESULTS： At EOT we noticed a significant decrease in ALT levels vs inclusion in all patients and this decrease did not differ significantly in group T vs group V. HOMA-IR significantly decreased at EOT vs inclusion in all patients but in group T, the mean HOMA-IR decrease per month was higher than in group V. NAS significantly diminished at EOT in all patients with a higher decrease in group T vs group V. CONCLUSION： Angiotensin receptor blockers seem to be efficient in hypertension-associated NASH. Telmisartan showed a higher efficacy regarding insulin resistance and histology, perhaps because of its specific PPAR-gamma ligand effect.

对老年2型糖尿病患者的运动指导

运动是糖尿病的有效疗法之一，尤其对该病的老年患者，有许多益处。通过参加适当的文娱活动，体育运动和体力劳动，可促进体重减轻并维持适当体重，使胰岛素受体数上升，提高胰岛素的敏感性，并促使肌肉利用脂肪酸，降低甘油三脂，极低密度的脂蛋白，提高高密度脂蛋白，从而减少胆固醇，还可减轻患者的压力和紧张性，使人心情舒畅。我们建议老年2型糖尿病患者不必多休息，鼓励其积极参加活动与适当的体力劳动，由于老年人具有活力，体力减退，生物效率减低，对环境和应激反应的能力减低等特点，所以在运动量，运动方法等方面有许多讲究，对老年2型糖尿病患者进行有针对性的运动指导，可减少盲目性，避免运动不当引起不良反应。

Breakfast,glycaemic index and health in young people

The often cited phrase 'breakfast is the most important meal of the day' may have been largely anecdotal and lacking empirical evidence originally,particularly where children and adolescents(young people) are concerned.However,there is now a large body of evidence demonstrating that regular breakfast consumption is associated with a variety of nutritional and lifestyle-related health outcomes in large diverse samples of young people,which may prevent weight gain,nutrient deficiency and reduce risk factors for chronic disease.This evidence has been reviewed previously,but the link between breakfast composition and health has received less attention.There is emerging evidence in young people that suggests certain breakfasts are particularly beneficial for health,with much of this evidence focusing on ready-to-eat cereals and breakfast glycaemic index(GI).Substituting a high GI(HGI) breakfast for a low GI(LGI) breakfast may be particularly beneficial for overweight young people through increased glycaemic control and satiety.Thus,the purpose of this paper is to extend previous reviews on breakfast consumption and health to provide a greater understanding of the role of breakfast composition,particularly breakfast GI.Unlike the evidence on breakfast consumption,which has often been based on large cross-sectional studies,the evidence on breakfast GI is based primarily on controlled experimental studies,often with relatively small samples.At times,it was necessary to refer to the adult-based literature in this review to support findings from young people or to highlight areas that are particularly lacking in empirical evidence in this population.Since breakfast consumption has declined in young people and also decreases from childhood to adolescence,strategies to promote regular consumption of a healthy breakfast in young people are warranted.Future research in young people should place greater emphasis on breakfast composition, consider the mechanisms controlling relationships between breakfast consumption and health,and investigate the benefits of habitual consumption of LGI compared with HGI breakfasts.

IL28B polymorphism as a predictor of antiviral response in chronic hepatitis C

AIM： To evaluate the effect of single nucleotide poly- morphisms of interleukin （IL）-28B, rs12979860 on progression and treatment response in chronic hepatitis C. METHODS： Patients （n = 64; 37 men, 27 women; mean age, 44 ＋ 12 years） with chronic hepatitis C, genotype 1, received treatment with peg-interferon plus ribavirin. Genotyping of rs12979860 was per- formed on peripheral blood DNA. Histopathological assessment of necroinflammatory grade and fibrosis stage were scored using the METAVIR system on a liver biopsy sample before treatment. Serum viral load, ami- notransferase activity, and insulin level were measured. Insulin resistance index, body mass index, waist/hip ratio, percentage of body fat and fibrosis progression rate were calculated. Applied dose of interferon and ribavirin, platelet and neutrophil count and hemoglobin level were measured. RESULTS： A sustained virological response （SVR） was significantly associated with IL28B polymorphism （CC vs -l-r allele： odds ratio （OR）, 25; CC vs CT allele： OR, 5.4）, inflammation activity （G 〈 1 vs G 〉 1： OR, 3.9）, fibrosis （F 〈 1 vs F 〉 1： OR, 5.9）, platelet count （〉 200 × 109/L vs 〈 200 ×109/L： OR, 4.7; OR in patients with genotype CT： 12.8）, fatty liver （absence vs presence of steatosis： OR, 4.8）, insulin resistance index （〈 2.5 vs 〉 2.5： OR, 3.9）, and baseline HCV viral load （〈 106 IU/mL vs 〉 106 IU/mL： OR, 3.0）. There was no association with age, sex, aminotransferases activity, body mass index, waist/hip ratio, or percentage body fat. There was borderline significance （P = 0.064） of increased fibrosis in patients with the I-I allele, and no differences in the insulin resistance index between groups of patients with CC, CT and -IF alleles （P = 0.12）. Spearman＇s rank correlation coefficient between insulin resistance and stage of fibrosis and body mass index was r = 0.618 and r = 0.605, respectively （P 〈 0.001）. Significant dif- ferences were found in the insulin resistance index （P = 0.01） between patients with and without steatosis. Patients with the C-I- allele and absence of a SVR had a higher incidence of requiring threshold dose reduction of interferon （P = 0.07）. CONCLUSION： IL28B variation is the strongest host factor not related to insulin resistance that determines outcome of antiviral therapy. Baseline platelet count predicts the outcome of antiviral therapy in CT allele patients.

Risk factors for prehypertension in Xinjiang Uygur population

Objective To assess the risk factors for prehypertension in Xinjiang Uygur population. Methods A cross-section study was conducted in a Xinjiang Uygur population（438 males and 716 females,aged 30 to 70 years）.The fasting lipid profiles,serum glucose,insulin,and uric acid were determined.Homeostasis model assessment of insulin resistance（HOMA-IR）index was used to assess insulin resistance（IR）.Binary logistic regression analysis was performed to determine risk factors for prehypertension.Blood pressure levels ofnormotensives and prehypertensives in different body mass index（BMI）categories were compared. Results Binary logistic regression analysis performed after adjustment for gender,lipids profiles,waist-to-hip ratio,uric acid,HOMA-IR,and lifestyle（alcohol drinking and smoking）showed a significantly increasing prevalence of prehypertension with BMI.The odds ratios for prehypertension against the lowest BMI group（separated by 24 and 28）were 1.934 and 2.490（95% confidence interval：1.435-2.606 and 1.825-3.399,respectively）.Age was independently correlated to the increasing prevalence of prehypertension.HOMA-IR was not associated with prehypertensive.The mean diastolic blood pressure（DBP）was significantly increased with BMI categories in either normotensives or prehypertensives（P〈0.001）while the mean systolic blood pressure（SBP）was significantly increased with BMI only in normotensives（P〈0.001）. Conclusions In Xinjiang Uygurs,BMI and age was the risk factors for prehypertension.DBP is significantly increased with BMI.IR is not associated with prehypertension.These findings emphasize the importance of management of obesity for the control of blood pressure and other cardiovascular complications.

司美格鲁肽联合罗格列酮治疗2型糖尿病的疗效观察

目的探讨司美格鲁肽联合罗格列酮治疗2型糖尿病的临床疗效。方法选取2021年5月—2023年7月黄山首康医院内分泌科收治的80例2型糖尿病患者,依据用药情况将所有患者分为对照组和治疗组,每组各40例。对照组患者口服马来酸罗格列酮片,4 mg/次,1次/d。治疗组患者在对照组的治疗基础上皮下注射司美格鲁肽注射液,0.25 mg/次,1次/周;28 d后,0.5 mg/次,1次/周。两组连续用药12周。观察两组的临床疗效和症状好转时间,比较两组治疗前后生活质量评定量表(SF-36)评分、糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞指数(HOMA-β)的变化情况。结果治疗后,治疗组总有效率是92.51%,显著高于对照组的77.50%(P<0.05)。治疗后,治疗组多尿、多饮、多食、体质量减少好转时间均显著短于对照组(P<0.05)。治疗后,两组SF-36评分均较同组治疗前显著提高(P<0.05);治疗后,治疗组SF-36评分高于对照组(P<0.05)。治疗后,治疗组Hb A1c、FPG、餐后2 h PG水平均较同组治疗前显著降低(P<0.05);治疗后,治疗组糖代谢指标低于对照组(P<0.05)。治疗后,两组FINS、HOMA-IR水平均显著降低,HOMA-β显著升高(P<0.05);治疗后,治疗组FINS、HOMA-IR指标低于对照组,HOMA-β指标高于对照组(P<0.05)。结论采用司美格鲁肽和罗格列酮协同治疗2型糖尿病,可较快改善患者临床症状,并有效调节糖代谢相关指标,患者生活质量提升明显,值得借鉴与应用。

Rat Hepatocyte Glucose Metabolism Is Affected by Caloric Restriction but not by Litter Size Reduction

This work aimed at investigating whether the liver glucose metabolism could have a role in any change of glucose homeostasis that might exist in the reduced-litter rat at the age of 60 days. Additionally, post-weaning caloric restriction and its hepatic effects were explored, as this intervention is reported as a useful measure against obesity and its related disturbances. The animals were raised in litters of nine （control, CG） or three pups during lactation. These small-litter pups were FG （fed freely） or subjected to 30% RG （caloric restriction） after weaning until 60 days of age. The increased adiposity induced by lactational overfeeding was not reversed by caloric restriction. Hepatocyte glucose metabolism and glucose tolerance test were not affected by litter size, but caloric restriction increased liver basal glucose release, diminished gluconeogenesis and retarded the glycemic decay during the insulin tolerance test. Liver glucose metabolism of young adult rats was not affected by lactational overfeeding. Up to this age, however, moderate caloric restriction had a potent influence that might compromise whole-body glucose homeostasis and prompt to insulin resistance.

热缺血时间对大鼠胰岛结构和功能的影响

目的 探讨胰腺热缺血时间对胰岛形态和功能的影响。方法 以Lewis大鼠的胰腺为研究对象 ,分别在大鼠被处死后立即、2 5min后及 30min后以胶原酶灌注 ,然后分离、纯化胰岛 ,观察各组所得胰岛的形态、活性、胰岛当量数 (IEQ)与功能。结果 各组均可获得形态完好的胰岛 ,胰岛细胞活率在 85 %以上 ;各组IEQ的差异无显著性 ;热缺血时间 2 5min组与立即灌注组相比 ,纯化后的胰岛细胞在低糖与高糖刺激下 ,胰岛素分泌量的差异无显著性 ,而热缺血时间 30min组与立即灌注组相比 ,胰岛素的分泌能力显著降低 (P <0 .0 1)。结论 热缺血时间不超过 2 5min时 ,分离、纯化后得到的胰岛在结构与功能方面的改变不显著 ,若热缺血时间延长到 30min时 。

高血压、糖尿病高血压患者胰岛素、胰岛素受体水平的观察

目的 观察高血压 (EHT)、糖尿病高血压 (DMHT)患者胰岛素、胰岛素受体水平的变化。方法 对 36例原发性高血压 ,30例糖尿病高血压及 2 0例正常人进行葡萄糖耐量试验 ,测定血浆胰岛素浓度和红细胞膜胰岛素受体数。结果 EHT组、DMHT组患者的收缩压和舒张压无显著性差异 (P >0 0 5 ) ,但两组均高于对照组 (P <0 0 1) ,EHT组、DMHT组患者的胆固醇、甘油三酯和对照组相比差异有显著性 ( P<0 0 1) ;EHT组各时相血糖与对照组相比 ,有差异 ( P<0 0 5 ) ,DMHT组各时相血糖与对照组相比有显著性差异 (P <0 0 1) ,EHT组各时相血Ins均高于对照组 (P <0 0 1) ,DMHT组各时相血Ins均低于对照组 (P <0 0 1) ,EHT组和DMHT组的EInsR均低于对照组 (P <0 0 1)。结论 EHT组血压与血Ins呈正相关 ,与EInsk呈负相关 ,DMHT组血压与血糖呈正相关 ,与血Ins和EInsR不相关 。

战胜“心理性胰岛素抵抗”

糖尿病患者朋友们应该都听说过胰岛素抵抗这种说法，我们有些药物的作用机理就是专门针对胰岛素抵抗从而发挥降糖作用的。所谓胰岛素抵抗是2型糖尿病及其他代谢综合征最重要的发病机制之一。它是指脂肪、肌肉、肝脏等靶组织细胞表面的胰岛素受体数量减少、亲和力下降，胰岛素敏感性因而减退，以致出现高胰岛素血症、B细胞功能障碍、血糖持续升高等，这可以称为“病理性胰岛素抵抗”。

高血糖是高血压的独立危险因素？

作者分析糖耐量低减者（ＩＧＴ）２５０例及正常糖耐量者（ＮＧＴ）１７５例的资料。ＩＧＴ者中高血压所占比例明显高于ＮＧＴ者（分别为３０．１４％、１３．１７％，Ｐ＜０．００１）；Ｐｅｒｓｏｎ相关分析中，收缩压、舒张压、平均血压均与体重指数，空腹及服糖后２小时血糖和胰岛素呈显著正相关；应用多因素回归分析，在调整年龄、性别、体重指数、血浆总胆固醇、空腹胰岛素等因素后，收缩压、舒张压、平均血压仍与服糖后２小时血糖呈独立正相关。提示高血糖可能为高血压的独立危险因素。

Antihyperglycemic, insulinsensitizing and antioxidant activities of the active fractions from Anoectochilus chapaensis

Anoectochilus chapaensis Gagnep. （Orchidaceae）, an indigenous and valuable Chinese folk medicine, has been widely used in China to treat diabetes. However, few reports are available about its constituents and activity. The present experiment was conducted to investigate the active fractions from A. chapaensis in diabetic rat model induced by high-fat diet plus streptozotocin. The total EtOH extract from the whole herbs ofA. chapaensis, half of which was partitioned in sequence with petrol ether （PE）, ethyl acetate （EtOAc）, n-BuOH and H2O, thus yielding four fractions, all of them were orally administered with an identical dose amount to 4 g/kg dried crude herbs once a day for consecutive two weeks to further investigate the antihyperglycemic activity. The EtOAc fraction caused a significant fall in the non-fasting blood glucose level of diabetic rats from （402.66±82.26） to （226.26±62.10） mg/dl, which may be attributed to ameliorating insulin resistance, modulating the activity of enzymatic antioxidants, reducing the content of NO, etc. Much more intact β cells in the islets of Langerhans in EtOAc fraction-treated groups than the negative control were observed, which greatly supported the morphological and functional elucidation. The OGTT evidenced that EtOAc fraction could promote the endurance capacity of acute glucose increase in diabetic rats. The EtOAc fraction of A. chapaensis contains some hypoglycemic and antioxidant principles with the potential to be developed further for the treatment of diabetes specifically associated with an insulin resistance state.

Effect of low-frequency electroacupuncture on pancreatic endocrine system in patients with simple obesity

Objective： To observe different efficacies of low-frequency electroacupuncture（EA） on pancreatic endocrine system in male and female patients with simple obesity due to spleen deficiency-related dampness. Methods： A total of 80 simple obesity patients were assigned to a male group（n=37） and a female group（n=43）. Both groups received a 30-minute low-frequency EA at Yinlingquan（SP 9）, Sanyinjiao（SP 6）, Zusanli（ST 36）, Fenglong（ST 40）, Quchi（LI 11）, Tianshu（ST 25）, Zhongwan（CV 12）, Shuifen（CV 9）, Qihai（CV 6） and Guanyuan（CV 4）. The treatment was done once a day, and 10 times made up a course of treatment. Patients in both groups were treated for 2 courses. Then the changes in body mass index（BMI）, serum insulin, insulin antibodies and leptin level in the two groups were observed and analyzed. Results： After treatment, the BMI, serum insulin, insulin antibodies and leptin levels were significantly reduced in both groups（P〈0.01 or P〈0.05）; the BMI and serum insulin concentration were more significantly reduced in the male group than those in the female group（both P〈0.01）; and the leptin level was more significantly reduced in the female group than that in the male group（P〈0.01）. Conclusion： EA can significantly regulate BMI and pancreatic endocrine system in both men and women with simple obesity; however, there is a gender difference： better effect for men in reducing BMI and serum insulin and better effect for women in reducing serum leptin level.

Effect of acupuncture on serum PYY and nesfatin-1 in obese patients with insulin resistance

Objective To observe the effect of acupuncture on serum peptide YY(PYY)and nesfatin-1 in obese patients with insulin resistance.Methods Ninety-eight obese patients with insulin resistance were divided into a control group and an observation group by the random number table method,with 49 cases in each group.The control group received exercise and dietary interventions,and the observation group received additional acupuncture treatment to the exercise and dietary interventions.The body mass index(BMI),body fat percentage,fasting insulin(FINS),fasting plasma glucose(FPG),homeostasis model assessment for insulin resistance(HOMA-IR),triglyceride(TG),total cholesterol(TC),and serum PYY and nesfatin-1 levels were compared before and after treatment.The efficacy was evaluated after treatment.Results The total effective rate was significantly higher in the observation group than in the control group(P<0.05).After treatment,the BMI,body fat percentage,and serum TG and TC levels decreased significantly in both groups(P<0.05),and were significantly lower in the observation group than those in the control group(P<0.05).The FINS,FPG,HOMA-IR,and serum PYY and nesfatin-1 levels of the control group were not significantly changed after treatment(P>0.05).The FINS,FPG and HOMA-IR of the observation group decreased significantly after treatment(P<0.05),and were lower than those in the control group(P<0.05).The serum PYY and nesfatin-1 levels of the observation group increased significantly after treatment(P<0.05),and were higher than those in the control group(P<0.05).Conclusion Based on exercise and dietary interventions,acupuncture is effective for obese patients with insulin resistance.It can reduce the BMI,body fat percentage,blood lipids,blood glucose,and serum insulin levels and improve insulin resistance.The action may be associated with the up-regulation of serum PYY and nesfatin-1.

快乐运动，善始善终

众所周知，运动有很多益处：它可以增强体质、提高抵抗力；可以减肥，促进新陈代谢。对糖尿病人而言，运动更具有降血糖和防治并发症的作用。运动时，能量的消耗不仅可使血糖迅速下降，而且还可通过胰岛素受体数量的增加、胰岛素作用的增强，使血糖得到较长时期的改善。运动还能促进血液在血管中的流动，降低血脂和血液黏稠度，有利于糖尿病慢性并发症的控制。

CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Objective：The aim of this study was to evaluate the concentrations of C-reactive protein （CRP）, tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6）, and the degree of homeostasis model assessment-insulin resistance （HOMA-IR） in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy. Methods：The study included 33 patients （25 females and 8 males; mean age 46 years） with body mass index （BMI） values of〉40 kg/m2. Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before （baseline data） and three weeks after the treatment. The control group consisted of 20 healthy volunteers （15 females and 5 males） with a mean age of 39 years and BMI values of≤24.9 kg/m2. Results：In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a de-creased level of high density lipoprotein （HDL）-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4%reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concen-tration of CRP, but no change in TNF-αor IL-6. HOMA-IR was significantly reduced. Conclusions：The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.