目的探究度拉糖肽联合达格列净治疗非酒精性脂肪肝(NAFLD)合并2型糖尿病(T2MD)的效果及对胰岛素抵抗和肝功能的影响。方法选取2020年11月至2022年11月浙江省台州市第一人民医院诊治的88例NAFLD合并T2MD患者,根据治疗方案分为2组,其中对...目的探究度拉糖肽联合达格列净治疗非酒精性脂肪肝(NAFLD)合并2型糖尿病(T2MD)的效果及对胰岛素抵抗和肝功能的影响。方法选取2020年11月至2022年11月浙江省台州市第一人民医院诊治的88例NAFLD合并T2MD患者,根据治疗方案分为2组,其中对照组(44例)接受达格列净治疗,联合组(44例)接受度拉糖肽联合达格列净治疗。连续治疗3个月后评估2组临床疗效和不良反应,比较2组胰岛素抵抗、肝功能、糖脂代谢指标。结果联合组临床疗效(89%)高于对照组(73%)(χ^(2)=4.021,P<0.05);联合组治疗后血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、γ-谷氨酰转肽酶(γ-GT)水平及胰岛抵抗指数(HOMA-IR)值低于对照组,胰岛素β细胞功能(HOMA-β)值高于对照组(t=2.841、3.102、2.985、2.018、2.394,P均<0.05);联合组治疗后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)低于对照组(t=2.621、3.961、2.143,P均<0.05);联合组治疗后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)低于对照组、血清高密度脂蛋白胆固醇(HDL-C)高于对照组(t=2.394、3.114、2.514、2.098,P均<0.05);2组不良反应发生情况比较,差异无统计学意义(χ^(2)=1.027,P>0.05)。结论度拉糖肽联合达格列净治疗NAFLD合并T2MD可明显改善其胰岛素抵抗和肝功能,治疗效果明显,值得临床推广。展开更多
The 576 patients with NIDDM were divided into different types according to the theory of syndrome differentiation of traditional chinese medicine and treated with acupuncture and moxibustion. Statisfactory results wer...The 576 patients with NIDDM were divided into different types according to the theory of syndrome differentiation of traditional chinese medicine and treated with acupuncture and moxibustion. Statisfactory results were obtained. The effective rate after one course of treatment (one month) was 81.25%, that after two courses was 87.67%, and that after three courses was 92.54%. The study showed that acupuncture and moxibustion are more effective on NIDDM in patients undergoing a long therapeutic course, in males than in females, in young patients than in older ones, in patients with a short course of disease than with a long course of disease, in patients with serious obesity than with slight obesity, in patients of excess type than those of excess type accompanied with deficiency tyep and deficeency type, in patients without complication than with complications and with with serious complications and in patients without family history of NIDDM than with a fimily history of NIDDM. This study proved that the treatment of NIDDM with acupuncture and moxibustion is safe, effective and has no side effect. Therefore, it is worth recommending.展开更多
文摘目的探究度拉糖肽联合达格列净治疗非酒精性脂肪肝(NAFLD)合并2型糖尿病(T2MD)的效果及对胰岛素抵抗和肝功能的影响。方法选取2020年11月至2022年11月浙江省台州市第一人民医院诊治的88例NAFLD合并T2MD患者,根据治疗方案分为2组,其中对照组(44例)接受达格列净治疗,联合组(44例)接受度拉糖肽联合达格列净治疗。连续治疗3个月后评估2组临床疗效和不良反应,比较2组胰岛素抵抗、肝功能、糖脂代谢指标。结果联合组临床疗效(89%)高于对照组(73%)(χ^(2)=4.021,P<0.05);联合组治疗后血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、γ-谷氨酰转肽酶(γ-GT)水平及胰岛抵抗指数(HOMA-IR)值低于对照组,胰岛素β细胞功能(HOMA-β)值高于对照组(t=2.841、3.102、2.985、2.018、2.394,P均<0.05);联合组治疗后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)低于对照组(t=2.621、3.961、2.143,P均<0.05);联合组治疗后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)低于对照组、血清高密度脂蛋白胆固醇(HDL-C)高于对照组(t=2.394、3.114、2.514、2.098,P均<0.05);2组不良反应发生情况比较,差异无统计学意义(χ^(2)=1.027,P>0.05)。结论度拉糖肽联合达格列净治疗NAFLD合并T2MD可明显改善其胰岛素抵抗和肝功能,治疗效果明显,值得临床推广。
文摘The 576 patients with NIDDM were divided into different types according to the theory of syndrome differentiation of traditional chinese medicine and treated with acupuncture and moxibustion. Statisfactory results were obtained. The effective rate after one course of treatment (one month) was 81.25%, that after two courses was 87.67%, and that after three courses was 92.54%. The study showed that acupuncture and moxibustion are more effective on NIDDM in patients undergoing a long therapeutic course, in males than in females, in young patients than in older ones, in patients with a short course of disease than with a long course of disease, in patients with serious obesity than with slight obesity, in patients of excess type than those of excess type accompanied with deficiency tyep and deficeency type, in patients without complication than with complications and with with serious complications and in patients without family history of NIDDM than with a fimily history of NIDDM. This study proved that the treatment of NIDDM with acupuncture and moxibustion is safe, effective and has no side effect. Therefore, it is worth recommending.
