Pelvic relaxation, a weakening of pelvic support structures, is an under-reported condition that affects a multitude of women. In the United States alone, more than 338,000 procedures for prolapse are performed annual...Pelvic relaxation, a weakening of pelvic support structures, is an under-reported condition that affects a multitude of women. In the United States alone, more than 338,000 procedures for prolapse are performed annually. Decreased collagen content has been noted in the tissues of women affected by this condition. Interestingly, biopsy specimens of women with striae also show a diminution of collagen. Using self-reported anonymous data, we compared the prevalence of striae in women with and without pelvic relaxation to see if an association between these two disorders of connective tissue existed. More than half the women with prolapse (54.7%) (n=41) reported striae, whereas only 25.0%of women in the non-prolapse group (n=8) reported striae (P< 0.01). Multivariate logistic regression analysis con-firmed striae as a significant risk factor for the development of clinical prolapse (odds ratio 3.12, P< 0.05). There appears to be a strong association between the presence of striae and the development of pelvic relaxation, which is unrelated to conventionally cited risk factors, such as age, weight, number of pregnancies, or postmenopausal status.展开更多
目的探讨乳腺浸润性导管癌剪切波弹性模量值与瘤体胶原纤维形态和排列方式的关系。方法对术前经剪切波声弹性成像定量检测和病理证实的35例乳腺浸润性导管癌组织标本行病理苦味酸天狼猩红特殊染色,对所含胶原纤维的类型进行定量分析,对...目的探讨乳腺浸润性导管癌剪切波弹性模量值与瘤体胶原纤维形态和排列方式的关系。方法对术前经剪切波声弹性成像定量检测和病理证实的35例乳腺浸润性导管癌组织标本行病理苦味酸天狼猩红特殊染色,对所含胶原纤维的类型进行定量分析,对胶原纤维的形态特点和排列方式进行分析和归类,并将其不同的归类与肿瘤最大弹性模量值进行对照。结果苦味酸天狼猩红特殊染色切片镜检示35例乳腺浸润性导管癌肿块中Ⅰ型胶原纤维占胶原纤维总面积的83%(959 771.75/1156 351.51);胶原纤维均呈长直形态,其中29例乳腺癌病灶中长直细胶原纤维的弹性平均值(152.9±93.4)k Pa高于6例乳腺癌病灶中长直粗胶原纤维的弹性值(74.8±6.4)k Pa;35例乳腺癌病灶中6例胶原纤维表现为蜂窝状排列方式、10例表现为片状排列、11例表现为分层排列,8例表现为交错状排列方式;乳腺癌病灶中4种排列方式的胶原纤维弹性最大平均值分别为252.2 k Pa、152.4 k Pa、120.6 k Pa和65.0 k Pa,其中以蜂窝状排列的胶原纤维弹性值最大。结论乳腺癌病灶中不同形态和不同排列方式的胶原纤维是浸润性导管癌肿瘤硬度不同的重要原因。展开更多
文摘Pelvic relaxation, a weakening of pelvic support structures, is an under-reported condition that affects a multitude of women. In the United States alone, more than 338,000 procedures for prolapse are performed annually. Decreased collagen content has been noted in the tissues of women affected by this condition. Interestingly, biopsy specimens of women with striae also show a diminution of collagen. Using self-reported anonymous data, we compared the prevalence of striae in women with and without pelvic relaxation to see if an association between these two disorders of connective tissue existed. More than half the women with prolapse (54.7%) (n=41) reported striae, whereas only 25.0%of women in the non-prolapse group (n=8) reported striae (P< 0.01). Multivariate logistic regression analysis con-firmed striae as a significant risk factor for the development of clinical prolapse (odds ratio 3.12, P< 0.05). There appears to be a strong association between the presence of striae and the development of pelvic relaxation, which is unrelated to conventionally cited risk factors, such as age, weight, number of pregnancies, or postmenopausal status.
文摘目的探讨乳腺浸润性导管癌剪切波弹性模量值与瘤体胶原纤维形态和排列方式的关系。方法对术前经剪切波声弹性成像定量检测和病理证实的35例乳腺浸润性导管癌组织标本行病理苦味酸天狼猩红特殊染色,对所含胶原纤维的类型进行定量分析,对胶原纤维的形态特点和排列方式进行分析和归类,并将其不同的归类与肿瘤最大弹性模量值进行对照。结果苦味酸天狼猩红特殊染色切片镜检示35例乳腺浸润性导管癌肿块中Ⅰ型胶原纤维占胶原纤维总面积的83%(959 771.75/1156 351.51);胶原纤维均呈长直形态,其中29例乳腺癌病灶中长直细胶原纤维的弹性平均值(152.9±93.4)k Pa高于6例乳腺癌病灶中长直粗胶原纤维的弹性值(74.8±6.4)k Pa;35例乳腺癌病灶中6例胶原纤维表现为蜂窝状排列方式、10例表现为片状排列、11例表现为分层排列,8例表现为交错状排列方式;乳腺癌病灶中4种排列方式的胶原纤维弹性最大平均值分别为252.2 k Pa、152.4 k Pa、120.6 k Pa和65.0 k Pa,其中以蜂窝状排列的胶原纤维弹性值最大。结论乳腺癌病灶中不同形态和不同排列方式的胶原纤维是浸润性导管癌肿瘤硬度不同的重要原因。
