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星形胶质细胞嘌呤能信号在癫痫中的作用
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作者 Ljiljana Nikolic Paola Nobili +1 位作者 Weida Shen Etienne Audinat 《神经损伤与功能重建》 2020年第8期F0003-F0003,共1页
癫痫是由神经元的超同步放电引起的不可预知的反复发作。越来越多的研究表明,星形胶质细胞向神经元传递信号的异常在神经网络的过度兴奋中起着重要作用。对多种中枢神经系统疾病(如阿尔茨海默病、卒中、重度抑郁、精神分裂症和癫痫)的... 癫痫是由神经元的超同步放电引起的不可预知的反复发作。越来越多的研究表明,星形胶质细胞向神经元传递信号的异常在神经网络的过度兴奋中起着重要作用。对多种中枢神经系统疾病(如阿尔茨海默病、卒中、重度抑郁、精神分裂症和癫痫)的病理学研究结果显示,嘌呤信号传导在神经元-胶质细胞和胶质细胞-胶质细胞相互作用中有重要的作用,嘌呤受体障碍可影响细胞间的信号传导。本综述将首先对星形胶质细胞影响神经元活动的机制进行分析总结。近期研究显示,星形胶质细胞嘌呤信号转导的异常促进了癫痫中神经元异常活动的出现,本综述也将对相关研究报道进行描述和总结。 展开更多
关键词 钙信号 细胞因子 胶质传输 炎症 胶质细胞
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Effects of transport on aerosols over the eastern slope of the Tibetan Plateau:synergistic contribution of Southeast Asia and the Sichuan Basin 被引量:1
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作者 SU Hong-Juan XIN Jin-Yuan +8 位作者 MA Yong-Jing LIU Zirui WEN Tian-Xue WANG Shi-Gong FAN Guang-Zhou LI Wei WANG Lu HE Zhi-Ming WANG Yue-Si 《Atmospheric and Oceanic Science Letters》 CSCD 2018年第5期425-431,共7页
The aerosol optical properties and chemical components of PM2.1(particulate matter with a diameter of 2.1μm or less)were investigated at Mount Gongga on the eastern slope of the Tibetan Plateau from April 2012 to Dec... The aerosol optical properties and chemical components of PM2.1(particulate matter with a diameter of 2.1μm or less)were investigated at Mount Gongga on the eastern slope of the Tibetan Plateau from April 2012 to December 2014.The annual mean aerosol optical depth(AOD)was 0.35±0.23,and the?ngstr?m exponent was 1.0±0.38.The AOD exhibited higher values in summer and winter,but lower values in spring and autumn.Dividing the observational periods into dry and wet seasons,the authors found that the concentrations of K^+,elemental carbon,secondary inorganic aerosols,and primary and secondary organic carbon in the dry(wet)season were 0.29(0.21),0.88(0.60),7.4(4.5),7.5(5.1),and 3.9(12)μg m?3,respectively.Combined with trajectory analysis,the authors found that higher concentrations of K^+,elemental carbon,and primary organic carbon indicated the effects of biomass burning from Southeast Asia during the dry season.However,the oxidation of volatile organic compounds was the main source of aerosols during the wet season,which originated from the Sichuan Basin. 展开更多
关键词 Tibetan Plateau aerosol optical depth aerosol components biomass burning regional transport
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