肺腺癌原发灶及其胸腔渗出液中MMP-2、E-cadherin和β-catenin的表达

目的 研究基质金属蛋白酶2(MMP 2)、上皮钙黏蛋白(E cadherin,E- cad)和β- 连环蛋白(β- catenin)在肺腺癌原发灶及其恶性胸腔渗出液中的表达和相关性及其与患者生存的关系。方法 采用免疫组织化学S- P法检测MMP 2、E cad和β- catenin在30例人原发性肺腺癌与肺腺癌并发的恶性胸腔渗出液中癌细胞表达的关系。结果 MMP 2、E cad和βcatenin在肺腺癌原发灶的阳性表达率分别低于恶性胸腔渗出液。肺腺癌原发灶中MMP 2、E- cad和β- catenin的表达与肺腺癌分化程度和淋巴结转移能力有关(P<0 .05);MMP 2和E -cad在原发灶中的表达呈负相关,在恶性胸腔渗出液中的表达无相关。E -cad和β-catenin在原发灶中的表达呈正相关,在恶性胸腔渗出液中的表达无相关。MMP 2阳性组肺腺癌患者的累积生存率低于MMP- 2阴性组(P<0 .05)。β- catenin阴性组肺腺癌患者的累积生存率低于β-catenin阳性组(P<0. 05)。结论 肺腺癌原发灶MMP 2的表达上调与E cad和β- catenin的表达下调在肺腺癌浸润、转移中起重要作用,可作为预测肺腺癌预后的指标之一。

用单克隆抗体115 D_8和DF_3检测胸腔渗出液中CA15-3的诊断价值

胸腔渗掖的常见病是肿瘤和结核，常用CGA、CA19-9和ADA进行鉴别。胸腔渗液中CA 15-3的水平尚无报道，为了帮助鉴别胸腔渗蔽是肿瘤性或结核性，作者测定了胸腔渗液中CA 15-3的水平。

化合物CHO2对角叉菜胶诱导的大鼠胸膜炎模型的影响

目的：本研究的目的是通过角叉菜胶致大鼠胸膜炎模型观察化合物CHO2的抗炎作用。 方法：角叉菜胶致大鼠胸膜炎模型48只健康雄性SD大鼠，随机分为空白对照组、模型对照组、吲哚美辛组（2mg／kg）、CHO2组（5mg／kg、10mg／kg、20mg／kg），每组8只。给药组每天灌胃一次，连续给药4天，在末次给药后0．5h造模，造模4h后检测胸腔渗出液体积、

Role of diaphragm in pancreaticopleural fistula

A pancreatic pleural effusion may result from a pancreatopleural fistula. We herein discuss two interesting issues in a similar case report of a pleural effusion caused after splenectomy, which was recently published in the World Journal of Gastroenterology . Pancreatic exudate passes directly through a natural hiatus in the diaphragm or by direct penetration through the dome of the diaphragm from a neighboring subdiaphragmatic collection. The diaphragmatic lymphatic "stomata" does not contribute to the formation of such a pleural effusion, as it is inaccurately mentioned in that report. A strictly conservative approach is recommended in that article as the management of choice. Although this may be an option in selected frail patients, there has been enough accumulative evidence that a pancreaticopleural fistula may be best managed by early endoscopy in order to avoid complications causing prolonged hospitalization.