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胸部肿瘤术后丁丙诺菲持续镇痛临床观察
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作者 吴芳红 冯瑞庆 闫仲生 《药物流行病学杂志》 CAS 2005年第2期68-69,共2页
目的:观察胸部肿瘤术后运用丁丙诺菲持续镇痛的疗效和安全性。方法:术后患者69例,麻醉浅者先给丁丙诺菲0.15mg,根据术中麻药耐受量,以丁丙诺菲0.6μg·kg-1·h-1,芬太尼0.3μg·kg-1.h-1为标准,上下浮动加入微量输液泵,同... 目的:观察胸部肿瘤术后运用丁丙诺菲持续镇痛的疗效和安全性。方法:术后患者69例,麻醉浅者先给丁丙诺菲0.15mg,根据术中麻药耐受量,以丁丙诺菲0.6μg·kg-1·h-1,芬太尼0.3μg·kg-1.h-1为标准,上下浮动加入微量输液泵,同时加入阿扎司琼10-20mg(或格拉司琼3-6mg),采用外周静脉50h匀速给药观察。根据疼痛级别,随时调整用量。结果:患者69例术后,疼痛级别评估均为0-3级,其中≤1级81.2%(56/69),≤2级8.7%(6/69),≤3级10.1%(7/69)。不良反应:血压下降19例,窦性心动过速13例,室性早搏、血压升高、呼吸抑制各1例,对症处理后恢复正常。结论:丁丙诺菲具有较好的持续镇痛效果,临床疗效确切,不良反应轻微。 展开更多
关键词 肿瘤 胸部/术后 丁丙诺菲 疗效 药物不良反应
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THE ANALYSIS OF CHANGES AND INFLUENCING FACTORS OF EARLY POSTTHORACOTOMY PULMONARY FUNCTION 被引量:5
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作者 崔玉尚 张志庸 徐协群 《Chinese Medical Sciences Journal》 CAS CSCD 2003年第2期105-110,共6页
Objective. To investigate the changes and influencing factors of early postoperative pulmonary functionof thoracotomy.Methods. Pre-and early postoperative pulmonary function was studied in 64 consecutive cases withopt... Objective. To investigate the changes and influencing factors of early postoperative pulmonary functionof thoracotomy.Methods. Pre-and early postoperative pulmonary function was studied in 64 consecutive cases withoptimal thoracotomy. Pain assessment was done before pulmonary function test, and the chief complaintsof patients were recorded after the procedure. The changing curves of pulmonary function were done andthe differences associated with groups, surgical styles, pain assessment, epidural analgesia, chief com-plaint and preoperative conditions were analyzed.Results. Pulmonary function was severely lowered to about 40% of the base line on the first day,and it was rehabilitated to about 60% of the base line on the eighth day. There was a greater gradienton the recovery curve on the 3rd and 4th days. Epidural analgesia was able to improve pain relaxationand pulmonary function in some degree. Single-factor analysis showed that postoperative pain, postopera-tive day and surgical style were the significant influencing factors for early postoperative pulmonary func-tion. By multiple-factor analysis, preoperative pulmonary function, age and postoperative pain were themain factors, while surgical style had only weak effect on it.Conclusions. Early postoperative pulmonary function is severely impaired by thoracotomy. It rehabili-tate gradually with time. Improvement of preoperative pulmonary function, reducing surgical procedure in-juries, especially injury to respiratory muscle system, and enough postoperative pain relief are the mostimportant means that would reduce pulmonary function impairment and consequently reduce postoperativepulmonary complications. 展开更多
关键词 THORACOTOMY early postoperative pulmonary function epidural analgesia
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