大剂量多巴胺滴定式给药救治心源性休克的临床分析

目的探究应用大剂量多巴胺滴定式给药方法对心源性休克治疗的临床疗效及治疗安全性,为今后的治疗提供参考和依据。方法选取2015年6月至2016年6月我院收治的20例心源性休克患者,均给予大剂量多巴胺滴定式治疗,记录患者救治后的并发症数据及治疗效果。结果治疗后1h患者收缩压中位数值(84.62±12.58)mm Hg与治疗后2h收缩压中位数(101.62±14.38)mm Hg显著高于治疗前收缩压数中位数值(48.59±5.79)mm Hg,差异具有显著的统计学意义(P<0.05);20例救治患者死亡0例,存活20例,存活率100%;20例患者中6例患者出现药物依赖现象,1例患者有轻微中枢神经系统兴奋征,不良反应发生率为35%。结论心源性休克患者应用大剂量多巴胺是有效且安全的,能够在较短时间内缓解症状,使患者血压恢复正常,值得临床推广并应用。

固体酸催化剂酸性分析方法的研究进展

介绍了固体酸催化剂酸性分析方法的研究进展,主要介绍了胺滴定法、红外光谱法、核磁共振法、程序升温脱附法及热分析法,并比较了这些分析方法的优缺点。目前人们广泛采用的是程序升温脱附和红外光谱法,前者可准确分析总酸量和酸强度,但无法区分酸的类型;而吡啶吸附红外光谱法可区分B酸和L酸,但对酸强度及总酸量的定量分析方面不很理想。新发展起来的31P核磁共振技术可较好地实现B酸和L酸的酸中心分布、酸量及酸强度的定性和定量分析。

分子筛催化剂的酸性表征及研究进展

综述了近年来分子筛表面酸性的表征与研究进展,主要介绍了吸附指示剂滴定法、程序升温脱附法、红外光谱法和核磁共振法,并比较了这些方法的优缺点。目前,人们广泛使用的是程序升温脱附法和红外光谱法,前者可以准确地分析总酸量和酸强度,但不能区分酸的类型;后者虽然可以区分B酸和L酸,但对酸强度和总酸量的定量分析不是很理想。随着固体核磁共振方法和高场光谱仪的发展,固体核磁共振已经成为解决分子筛体系中各种基本科学问题的重要工具。

The Syntheses of β-Carboline-3-carboxamides Derivatives and TheirInteraction with DNA

To study the interactions of these compounds with calf thymus DNA(CT-DNA), seven b-carboline-3-carboxamides were designed and synthesized. The interactions of these compounds with CT-DNA were determined by the viscometric titration assay and Tm (melting temperature) value assay. Binding strengths were evaluated by spectrophotometric titration experiment and microcalorimetric measurement. The interactions of these compounds were tested with CT-DNA. It was showed that all of these compounds were able to change the Tm value of CT-DNA. The results of viscometric titration assay indicated that these compounds interacted with CT-DNA by intercalation. Spectrophotometric titration experiment showed that the binding strengths of these compounds with CT-DNA were different, which was well in agreement with the cell culture results. The binding was driven by entropy according to the results of the microcalorimetric measurement. This series of b-carboline-3-carboxamides is DNA targeting compounds. Their obvious antitumor biological effect is based on the intercalation with DNA base-pairs.

铌钛合金中钛含量的不确定度评定

通过对铌钛合金中钛含量的检测过程出现的不确定度进行分析归类,发现主要误差来源分为如下几个方面,分别为钛标准溶液配置、试样称重、滴定体积、移液管体积、容量瓶体积、测试人员某些操作不足够规范等,这些都有可能造成测试结果的偏差;在此基础上对分析结果的不确定度进行了评定计算得到了各分量标准不确定度以及合成标准不确定度。