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基于任务剖面的海战场信息系统能力评估试验设计方法
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作者 董亚卓 王成飞 郑锐 《指挥控制与仿真》 2022年第1期131-135,共5页
针对海战场信息系统能力评估试验涉及场景、装备、科目多,组织困难的特点,提出了一种基于任务剖面的海战场信息系统能力评估试验设计方法,将海战场信息系统能力评估试验需求和试验内容基于任务剖面进行精细化划分,便于针对性组织实兵试... 针对海战场信息系统能力评估试验涉及场景、装备、科目多,组织困难的特点,提出了一种基于任务剖面的海战场信息系统能力评估试验设计方法,将海战场信息系统能力评估试验需求和试验内容基于任务剖面进行精细化划分,便于针对性组织实兵试验、实验室试验、仿真验证等,规范、清晰试验组织流程,最大化复用结论。 展开更多
关键词 海战场信息系统 任务剖面 能力评估试验
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Antagomir Dependent MicroRNA-205 Reduction Enhances Adhesion Ability of Human Corneal Epithelial Keratinocytes 被引量:1
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作者 Jun Li Hua Bai +5 位作者 Yong Zhu Xiao-yan Wang Fang Wang Jun-wu Zhang Robert M. Lavker Jia Yu 《Chinese Medical Sciences Journal》 CAS CSCD 2010年第2期65-70,共6页
Objective To investigate the effect of microRNA-205 reduction by antagomirs on adhesion ability of normal human corneal epithelial keratinocytes(NHCEKs).Methods Antagomir-205,complementary and inhibitory to microRNA-2... Objective To investigate the effect of microRNA-205 reduction by antagomirs on adhesion ability of normal human corneal epithelial keratinocytes(NHCEKs).Methods Antagomir-205,complementary and inhibitory to microRNA-205,was used to suppress endogenous microRNA-205 in NHCEKs.The adhesion ability of treated NHCEKs was then assessed by cell adhesion assay.Immunoblot and immunohistochemistry were conducted to determine the level of two focal adhesion-related proteins,focal adhesion kinase(FAK) and paxillin(Pax).Phalloidin staining was performed to measure the level of filamentous actin in antagomir-treated NHCEKs.Results Antagomir-205 markedly reduced the level of microRNA-205 in NHCEKs and significantly enhanced adhesion ability of NHCEKs(P<0.01).Further protein analysis validated that inhibition of mi-croRNA-205 increased the number of phosphorylated FAK and phosphorylated Pax,and decreased filamen-tous actin.Conclusion Our findings suggest that microRNA-205 has down-regulating effect on cell motility in NHCEKs. 展开更多
关键词 corneal epithelium cell signaling MICRORNA
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