AIM to evaluate gender differences in the aspect of ghrelin,nociception-related genes and psychological aspects and the quality of life(Qo L) in Korean functional dyspepsia(FD) patients.METHODS Total of 191 persons we...AIM to evaluate gender differences in the aspect of ghrelin,nociception-related genes and psychological aspects and the quality of life(Qo L) in Korean functional dyspepsia(FD) patients.METHODS Total of 191 persons were prospectively enrolled between March 2013 and May 2016 in Seoul National Bundang Hospital,and classified into control and FD group based on ROME Ⅲ criteria. Questionnaire included assessment for dyspepsia symptoms,Qo L and anxiety or depression. Preproghrelin and nociception genes in the gastric mucosa and plasma acyl/des-acyl ghrelin were measured. RESULTS Lower level of plasma acyl ghrelin in FD patients compared to control was significant only in male(15.9 fmol/m L vs 10.4 fmol/m L,P = 0.017). Significantly higher m RNA expressions of nerve growth factor and transient receptor potential vanilloid receptor 1 were observed in male(P = 0.002 and P = 0.014,respectively) than in female. In contrast,female FD patients had a higher anxiety and depression score than male FD(P = 0.029),and anxiety score was correlated with epigastric pain only in female FD patients(female: Spearman rho = 0.420,P = 0.037). The impairment of overall Qo L was more prominent in female FD patients than male patients(5.4 ± 0.3 vs 6.5 ± 0.3,P = 0.020). CONCLUSION Gender differences of ghrelin and nociception-related genes in male and psychological factors in female underlie FD symptoms. More careful assessment of psychological or emotional status is required particularly for the female FD patients.展开更多
Previously we have determined the dilute mixture transport properties of slightly polar fluorocarbons using the inverted intermolecular potential energies(Ind. Eng. Chem. Res. 45(2006) 9211–9223). In the present pape...Previously we have determined the dilute mixture transport properties of slightly polar fluorocarbons using the inverted intermolecular potential energies(Ind. Eng. Chem. Res. 45(2006) 9211–9223). In the present paper, the corresponding states correlations for reduced viscosity collision integrals were employed to obtain effective unlike interaction potential models for dilute binary mixtures of highly polar molecule ammonia with noble gases.The inverted potentials were fitted to the Morse–Spline–van der Waals(MSV), model potential. The method of least-squares fitting was then applied to identify best consistence force parameters for each ammonia-noble gas mixture, taking advantage of experimental viscosities, diffusion coefficients and thermal conductivities.The proposed potential models were compared with those obtained from other sources, in order to assess the extent of their validity.The potentials were later employed to calculate transport properties of the studied mixtures. Then, results were compared with those reported in the literature, which led to the acceptable agreement.展开更多
Performance-Based Design （PBD） is a more rational approach, particularly in seismic environments. In this approach it is relevant the performance required to structures and to geotechnical works, as well as the geot...Performance-Based Design （PBD） is a more rational approach, particularly in seismic environments. In this approach it is relevant the performance required to structures and to geotechnical works, as well as the geotechnical constitutive models used to predict the performance. The parameters of the constitutive models are related in turn to soil properties. So soil properties are a key point for Performance-Based Design. Questions arising are： （i） which are the more relevant soil properties to solve a specific PBD geotechnical problem？ （ii） which are the more relevant model parameters and how they can be evaluated and/or correlated to soil properties？ （iii） which is the role of the soil parameters uncertainty in Performance-Based Design？ An answer to these questions is given in this paper, outlining the potential offered by the new advanced in-situ and laboratory tests and discussing the performance required by some geotechnical works.展开更多
基金Supported by Support Program for Women in Science,Engineering and Technology through the National Research Foundation of Korea funded by the Ministry of Science,ICT and Future Planning,no.2016H1C3A1903202
文摘AIM to evaluate gender differences in the aspect of ghrelin,nociception-related genes and psychological aspects and the quality of life(Qo L) in Korean functional dyspepsia(FD) patients.METHODS Total of 191 persons were prospectively enrolled between March 2013 and May 2016 in Seoul National Bundang Hospital,and classified into control and FD group based on ROME Ⅲ criteria. Questionnaire included assessment for dyspepsia symptoms,Qo L and anxiety or depression. Preproghrelin and nociception genes in the gastric mucosa and plasma acyl/des-acyl ghrelin were measured. RESULTS Lower level of plasma acyl ghrelin in FD patients compared to control was significant only in male(15.9 fmol/m L vs 10.4 fmol/m L,P = 0.017). Significantly higher m RNA expressions of nerve growth factor and transient receptor potential vanilloid receptor 1 were observed in male(P = 0.002 and P = 0.014,respectively) than in female. In contrast,female FD patients had a higher anxiety and depression score than male FD(P = 0.029),and anxiety score was correlated with epigastric pain only in female FD patients(female: Spearman rho = 0.420,P = 0.037). The impairment of overall Qo L was more prominent in female FD patients than male patients(5.4 ± 0.3 vs 6.5 ± 0.3,P = 0.020). CONCLUSION Gender differences of ghrelin and nociception-related genes in male and psychological factors in female underlie FD symptoms. More careful assessment of psychological or emotional status is required particularly for the female FD patients.
文摘Previously we have determined the dilute mixture transport properties of slightly polar fluorocarbons using the inverted intermolecular potential energies(Ind. Eng. Chem. Res. 45(2006) 9211–9223). In the present paper, the corresponding states correlations for reduced viscosity collision integrals were employed to obtain effective unlike interaction potential models for dilute binary mixtures of highly polar molecule ammonia with noble gases.The inverted potentials were fitted to the Morse–Spline–van der Waals(MSV), model potential. The method of least-squares fitting was then applied to identify best consistence force parameters for each ammonia-noble gas mixture, taking advantage of experimental viscosities, diffusion coefficients and thermal conductivities.The proposed potential models were compared with those obtained from other sources, in order to assess the extent of their validity.The potentials were later employed to calculate transport properties of the studied mixtures. Then, results were compared with those reported in the literature, which led to the acceptable agreement.
文摘Performance-Based Design （PBD） is a more rational approach, particularly in seismic environments. In this approach it is relevant the performance required to structures and to geotechnical works, as well as the geotechnical constitutive models used to predict the performance. The parameters of the constitutive models are related in turn to soil properties. So soil properties are a key point for Performance-Based Design. Questions arising are： （i） which are the more relevant soil properties to solve a specific PBD geotechnical problem？ （ii） which are the more relevant model parameters and how they can be evaluated and/or correlated to soil properties？ （iii） which is the role of the soil parameters uncertainty in Performance-Based Design？ An answer to these questions is given in this paper, outlining the potential offered by the new advanced in-situ and laboratory tests and discussing the performance required by some geotechnical works.
