AIM:To evaluate the effectiveness of omega-3 polyunsaturated fatty acid(ω-3 PUFA) administration on liver regeneration after 90% partial hepatectomy(PH) in rats.METHODS:ω-3 PUFAs were intravenously injected in the ...AIM:To evaluate the effectiveness of omega-3 polyunsaturated fatty acid(ω-3 PUFA) administration on liver regeneration after 90% partial hepatectomy(PH) in rats.METHODS:ω-3 PUFAs were intravenously injected in the ω-3 PUFA group before PH surgery.PH,sparing only the caudate lobe,was performed in both the control and the ω-3 PUFA group.Survival rates,liver weight/body weight ratios,liver weights,HE staining,transmission electron microscope imaging,nuclearassociated antigen Ki-67,enzyme-linked immunosorbent assay and signal transduction were evaluated to analyze liver regeneration.RESULTS:All rats in the control group died within 30 h after hepatectomy.Survival rates in the ω-3 PUFA group were 20/20 at 30 h and 4/20 1 wk after PH.Liver weight/body weight ratios and liver weights increased significantly in the ω-3 PUFA group.The structure of sinusoidal endothelial cells and space of Disse was greatly restored in the ω-3 PUFA group compared to the control group after PH.In the ω-3 PUFA group,interleukin(IL)-4 and IL-10 levels were significantly increased whereas IL-6 and tumor necrosis factor-levels were dramatically decreased.In addition,activation of protein kinase B(Akt) and of signal transducer and activator of transcription 3 signaling pathway were identified at an earlier time after PH in the ω-3 PUFA group.CONCLUSION:Omega-3 polyunsaturated fatty acids may prevent acute liver failure and promote liver regeneration after 90% hepatectomy in rats.展开更多
Fossil fuels are non-renewable, and their quantities have been reducing because of pumping. On the other hand, the traffic is still developing and needs for fuels are growing. As a consequence people are forced to loo...Fossil fuels are non-renewable, and their quantities have been reducing because of pumping. On the other hand, the traffic is still developing and needs for fuels are growing. As a consequence people are forced to look for other sources of getting fuel. Additional reason for this has been steadily boosting the prices of crude oil and gas. Diesel, as fuel that is often used, is possible to produce from different feedstock （oil rape, soybean, sunflower, palm, waste animal fats, algae, etc）. In this paper, the author analyzes the possibility of obtaining biodiesel from algae and the feasibility of such a method of producing biodiesel. Algae for biodiesel production are analyzed and the systems in which they are growing are described. Experience in this area is described as well as opportunities for further development of technology for getting biodiesel from algae. Algae are very resistant and can grow virtually anywhere in the desert, in salt and fresh water and even in the waste water. Algae can reproduce quickly; they use C02 for photosynthesis and less water than other crops. Bio fuel from algae is biodegradable and contains no sulphur and it is not toxic.展开更多
基金Supported by The China National Key S and T Projects for Major Infectious Diseases,No. 2008ZX10002-26
文摘AIM:To evaluate the effectiveness of omega-3 polyunsaturated fatty acid(ω-3 PUFA) administration on liver regeneration after 90% partial hepatectomy(PH) in rats.METHODS:ω-3 PUFAs were intravenously injected in the ω-3 PUFA group before PH surgery.PH,sparing only the caudate lobe,was performed in both the control and the ω-3 PUFA group.Survival rates,liver weight/body weight ratios,liver weights,HE staining,transmission electron microscope imaging,nuclearassociated antigen Ki-67,enzyme-linked immunosorbent assay and signal transduction were evaluated to analyze liver regeneration.RESULTS:All rats in the control group died within 30 h after hepatectomy.Survival rates in the ω-3 PUFA group were 20/20 at 30 h and 4/20 1 wk after PH.Liver weight/body weight ratios and liver weights increased significantly in the ω-3 PUFA group.The structure of sinusoidal endothelial cells and space of Disse was greatly restored in the ω-3 PUFA group compared to the control group after PH.In the ω-3 PUFA group,interleukin(IL)-4 and IL-10 levels were significantly increased whereas IL-6 and tumor necrosis factor-levels were dramatically decreased.In addition,activation of protein kinase B(Akt) and of signal transducer and activator of transcription 3 signaling pathway were identified at an earlier time after PH in the ω-3 PUFA group.CONCLUSION:Omega-3 polyunsaturated fatty acids may prevent acute liver failure and promote liver regeneration after 90% hepatectomy in rats.
文摘Fossil fuels are non-renewable, and their quantities have been reducing because of pumping. On the other hand, the traffic is still developing and needs for fuels are growing. As a consequence people are forced to look for other sources of getting fuel. Additional reason for this has been steadily boosting the prices of crude oil and gas. Diesel, as fuel that is often used, is possible to produce from different feedstock （oil rape, soybean, sunflower, palm, waste animal fats, algae, etc）. In this paper, the author analyzes the possibility of obtaining biodiesel from algae and the feasibility of such a method of producing biodiesel. Algae for biodiesel production are analyzed and the systems in which they are growing are described. Experience in this area is described as well as opportunities for further development of technology for getting biodiesel from algae. Algae are very resistant and can grow virtually anywhere in the desert, in salt and fresh water and even in the waste water. Algae can reproduce quickly; they use C02 for photosynthesis and less water than other crops. Bio fuel from algae is biodegradable and contains no sulphur and it is not toxic.
