糖尿病的发生率逐渐升高,尤其是2型糖尿病。随着糖尿病病程的增加,各项并发症的发病率也随之升高。尤其是2型糖尿病导致的慢性并发症,对人们的健康、心理及经济等各个方面均有一定的影响。近几年的研究均表明了脂质代谢对糖尿病的发病...糖尿病的发生率逐渐升高,尤其是2型糖尿病。随着糖尿病病程的增加,各项并发症的发病率也随之升高。尤其是2型糖尿病导致的慢性并发症,对人们的健康、心理及经济等各个方面均有一定的影响。近几年的研究均表明了脂质代谢对糖尿病的发病机制及其并发症的发生及进展有一定的影响。载脂蛋白B/A-1比值作为新的代谢紊乱标志物的指标之一,可评价糖尿病患者血管相关并发症。本文就载脂蛋白B/A-1比值在2型糖尿病血管并发症中的作用的相关研究进行综述。The prevalence of type 2 diabetes is on the rise, leading to an increase in associated complications over time. In particular, the chronic complications caused by type 2 diabetes have a certain impact on people’s health, psychology and economy. Recent studies have highlighted the impact of lipid metabolism on the development and progression of diabetes-related complications. Given that the ApoB/A-1 ratio can serve as a valuable indicator for assessing metabolic disorders and evaluating chronic complications in patients with diabetes. This review provides an overview of relevant research concerning the role of ApoB/A-1 ratio in vascular complications of type 2 diabetes.展开更多
AIM: To evaluate the clinical value of plasma apolipoprotein A-I (Apo A-I) as a marker of fibrosis in children with chronic hepatitis B (CHB).METHODS: Liver biopsy specimens from 49 children with CHB were evaluated by...AIM: To evaluate the clinical value of plasma apolipoprotein A-I (Apo A-I) as a marker of fibrosis in children with chronic hepatitis B (CHB).METHODS: Liver biopsy specimens from 49 children with CHB were evaluated by using Knodell index. Plasma Apo A-I level was measured after 12-h fasting. Student's ttest, Spearman's correlation test and receptor-operating characteristic (ROC) curve were used for statistical evaluation.RESULTS: Mean Apo A-I level of the patients was not different from that of controls (P>0.05). Six (8.7%) children had fibrosis score of more than 2 (severe fibrosis). No difference in the level of mean plasma Apo A-I was found among children with and without severe fibrosis (P>0.05). No correlation between Apo A-I level and fibrosis scores was found (P>0.05). The area under the ROC curve was 0.407~0.146 (P>0.05).CONCLUSION: Severe fibrosis is not common in children with CHB and plasma Apo A-I level is not a reliable indicator of fibrosis.展开更多
文摘糖尿病的发生率逐渐升高,尤其是2型糖尿病。随着糖尿病病程的增加,各项并发症的发病率也随之升高。尤其是2型糖尿病导致的慢性并发症,对人们的健康、心理及经济等各个方面均有一定的影响。近几年的研究均表明了脂质代谢对糖尿病的发病机制及其并发症的发生及进展有一定的影响。载脂蛋白B/A-1比值作为新的代谢紊乱标志物的指标之一,可评价糖尿病患者血管相关并发症。本文就载脂蛋白B/A-1比值在2型糖尿病血管并发症中的作用的相关研究进行综述。The prevalence of type 2 diabetes is on the rise, leading to an increase in associated complications over time. In particular, the chronic complications caused by type 2 diabetes have a certain impact on people’s health, psychology and economy. Recent studies have highlighted the impact of lipid metabolism on the development and progression of diabetes-related complications. Given that the ApoB/A-1 ratio can serve as a valuable indicator for assessing metabolic disorders and evaluating chronic complications in patients with diabetes. This review provides an overview of relevant research concerning the role of ApoB/A-1 ratio in vascular complications of type 2 diabetes.
文摘AIM: To evaluate the clinical value of plasma apolipoprotein A-I (Apo A-I) as a marker of fibrosis in children with chronic hepatitis B (CHB).METHODS: Liver biopsy specimens from 49 children with CHB were evaluated by using Knodell index. Plasma Apo A-I level was measured after 12-h fasting. Student's ttest, Spearman's correlation test and receptor-operating characteristic (ROC) curve were used for statistical evaluation.RESULTS: Mean Apo A-I level of the patients was not different from that of controls (P>0.05). Six (8.7%) children had fibrosis score of more than 2 (severe fibrosis). No difference in the level of mean plasma Apo A-I was found among children with and without severe fibrosis (P>0.05). No correlation between Apo A-I level and fibrosis scores was found (P>0.05). The area under the ROC curve was 0.407~0.146 (P>0.05).CONCLUSION: Severe fibrosis is not common in children with CHB and plasma Apo A-I level is not a reliable indicator of fibrosis.
