Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have ...Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have been found to be in-volved in the development of IPAH.With proteomic techniques,profiling of human plasma proteome becomes more feasible in searching for disease-related markers.In present study,we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum.Thirteen spots had changed significantly in IPAH com-pared with healthy controls and were identified by LC-MS/MS.Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.展开更多
Based on the study of the harmonic suppression on DC side of the multi-pulse rectification system,a software platform is established in Matlab environment.The phase-shift angle is studied from the aspects of system st...Based on the study of the harmonic suppression on DC side of the multi-pulse rectification system,a software platform is established in Matlab environment.The phase-shift angle is studied from the aspects of system stability and economy,analyzing the effects of phase-shift angle on the input-side line current,the output-side voltage ripple,the equivalent capacity of autotransformer and other auxiliary devices in 12-pulse rectifier system.The software platform can complete the analysis only by inputting the initial conditions,eliminating the derivation of the intermediate formula and reducing the complexity of the system analysis,and have good scalability.The simulation results show that the system can effectively analyze the influence of phase angle on 12-pulse star-connected transformer.展开更多
Under the inflammable or explosive environment, the direct measurement methods by opening up the explo- sion-proof shell of electrical installations were not adopted. So, it＇s impossible to have a quantitative analys...Under the inflammable or explosive environment, the direct measurement methods by opening up the explo- sion-proof shell of electrical installations were not adopted. So, it＇s impossible to have a quantitative analysis on the limit of conducted disturbance for electrical fast transient burst （EFT/B） in such dangerous environments. Transient conducted coupling model, which using EFT/B as its excitation source, can be built based on circuit and electromagnetic field theory. Furthermore, numerical analysis was performed. The results indicate that the capacitive coupling voltage is the same polarity as EFT/B, and is the main disturbance form of conducted coupling in mines. The inductive coupling voltage is reversed polarity with the ca- pacitive coupling voltage, and both peaks appear only in the rising time of EFT/B, which increase with the rising of load resistance. Moreover, the cable coupling voltage on the side of disturbance source is higher than the one on the other side in tunnel. To reduce the common resistance can suppress the resistive coupling disturbance.展开更多
Background： AH （Arterial hypertension） due to the extremely high incidence is the most important risk factor for development of myocardial infarctions, strokes and lethal outcomes. It is very important to identify...Background： AH （Arterial hypertension） due to the extremely high incidence is the most important risk factor for development of myocardial infarctions, strokes and lethal outcomes. It is very important to identify a group of patients with increased risk of adverse outcomes to modify treatment and prevention. Significant assistance in resolving this problem is to provide a method of HM （Holter monitoring） which allows estimating the HRV （heart rate variability） and HRT （heart rate turbulence） parameters that are independent risk predictors of sudden cardiac death. The aim of our study was to assess HRV and HRT parameters in patients with AH of the II degree. Materials and methods： We have studied parameters of HRV and HRT in 214 patients with AH of the II-nd degree aged 35 to 70 （57.7 ± 7.6） years： 121 women （56.5%） and 93 men （43.5%）. All patients underwent electrocardiography and echocardiography. Statistical analysis of the results has been made using the analytical package Statistics 10.0. Results： The parameters of HRV and HRT in patients with AH of the II degree were studied. Statistically significant correlations of the HRV parameters with the age of patients, average HR, circadian index, and EF （ejection fraction） were revealed. Statistically significant correlations of the HRT parameters with the LVMI （left ventricular mass index）, EF, HR average were received. High level of the statistical significance of the interrelation of HRT parameters （TO and TS） has been revealed. Conclusions： The received results can be used during the selection of the group of patients with AH having high risk for unfavorable outcomes. Taking into account the features of the HRV and turbulence parameters and factors associated with them this will enable the individualization of the assessment of the risk in AH as much as possible and prescription of adequate treatment for each patient.展开更多
基金Project (No. A-007) supported by the Key Medicine Foundation of Zhejiang Province, China
文摘Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have been found to be in-volved in the development of IPAH.With proteomic techniques,profiling of human plasma proteome becomes more feasible in searching for disease-related markers.In present study,we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum.Thirteen spots had changed significantly in IPAH com-pared with healthy controls and were identified by LC-MS/MS.Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.
基金National Natural Science Foundation of China(Nos.51367010,51867012)Lanzhou City Talent Innovation and Entrepreneurship Science and Technology Program Subsidy(No.2017-RC-51)。
文摘Based on the study of the harmonic suppression on DC side of the multi-pulse rectification system,a software platform is established in Matlab environment.The phase-shift angle is studied from the aspects of system stability and economy,analyzing the effects of phase-shift angle on the input-side line current,the output-side voltage ripple,the equivalent capacity of autotransformer and other auxiliary devices in 12-pulse rectifier system.The software platform can complete the analysis only by inputting the initial conditions,eliminating the derivation of the intermediate formula and reducing the complexity of the system analysis,and have good scalability.The simulation results show that the system can effectively analyze the influence of phase angle on 12-pulse star-connected transformer.
基金Supported by the National Natural Science Foundation of China （50674093） the Project of Fujian Provincial Education Department （JA11098）
文摘Under the inflammable or explosive environment, the direct measurement methods by opening up the explo- sion-proof shell of electrical installations were not adopted. So, it＇s impossible to have a quantitative analysis on the limit of conducted disturbance for electrical fast transient burst （EFT/B） in such dangerous environments. Transient conducted coupling model, which using EFT/B as its excitation source, can be built based on circuit and electromagnetic field theory. Furthermore, numerical analysis was performed. The results indicate that the capacitive coupling voltage is the same polarity as EFT/B, and is the main disturbance form of conducted coupling in mines. The inductive coupling voltage is reversed polarity with the ca- pacitive coupling voltage, and both peaks appear only in the rising time of EFT/B, which increase with the rising of load resistance. Moreover, the cable coupling voltage on the side of disturbance source is higher than the one on the other side in tunnel. To reduce the common resistance can suppress the resistive coupling disturbance.
文摘Background： AH （Arterial hypertension） due to the extremely high incidence is the most important risk factor for development of myocardial infarctions, strokes and lethal outcomes. It is very important to identify a group of patients with increased risk of adverse outcomes to modify treatment and prevention. Significant assistance in resolving this problem is to provide a method of HM （Holter monitoring） which allows estimating the HRV （heart rate variability） and HRT （heart rate turbulence） parameters that are independent risk predictors of sudden cardiac death. The aim of our study was to assess HRV and HRT parameters in patients with AH of the II degree. Materials and methods： We have studied parameters of HRV and HRT in 214 patients with AH of the II-nd degree aged 35 to 70 （57.7 ± 7.6） years： 121 women （56.5%） and 93 men （43.5%）. All patients underwent electrocardiography and echocardiography. Statistical analysis of the results has been made using the analytical package Statistics 10.0. Results： The parameters of HRV and HRT in patients with AH of the II degree were studied. Statistically significant correlations of the HRV parameters with the age of patients, average HR, circadian index, and EF （ejection fraction） were revealed. Statistically significant correlations of the HRT parameters with the LVMI （left ventricular mass index）, EF, HR average were received. High level of the statistical significance of the interrelation of HRT parameters （TO and TS） has been revealed. Conclusions： The received results can be used during the selection of the group of patients with AH having high risk for unfavorable outcomes. Taking into account the features of the HRV and turbulence parameters and factors associated with them this will enable the individualization of the assessment of the risk in AH as much as possible and prescription of adequate treatment for each patient.
