脉律定治疗糖尿病性周围神经疼痛40例

糖尿病性周围神经病变多见,是糖尿病的主要并发症之一,常表现为肢体自发性疼痛,尤以下肢多见。目前尚缺乏有效的治疗方法,我们自1989年试用脉律定治疗40例,报道如下。

Frequent Ventricular Extrasystole Treated by Needling Neiguan(PC 6)plus Oral Administration of Mexiletine——A Report of 30 Cases

Purpose: To observe the therapeutic effect of needling at Neiguan (PC 6) plus oral administration of mexiletine. Methods: 60 cases of frequent ventricular extrasystole were randomly divided into two groups: a treatment group, and a control group. In the control group, mexiletine was orally administered, and in the treatment group needling at bilateral Neiguan (PC 6) plus oral administration of mexiletine were given. 2 weeks of treatments constituted a therapeutic course. Results: Of the 30 cases in the treatment group, 23 cases were markedly effective, 5 cases improved, and 2 cases failed; while in the control group 16 cases were markedly effective, 8 cases improved, 4 cases failed, and 2 cases aggravated. The total effective rates of 90.3% and 80.0%, respectively in the treatment and control groups showed a very significant difference between the two groups (P<0.01). Conclusion: Needling at bilateral Neiguan (PC 6) may enhance the therapeutic effect for frequent ventricular extrasystole.

Effects of Dingjifumai Decoction on Electrocardiogram and sodium potassium pump of rats with ventricular arrhythmia

Objective:To investigate the effect of Dingjifumai Decoction(DJFM)on Electrocardiogram(ECG)and sodium potassium pump in rats with ventricular arrhythmia.Methods:Forty healthy male SD rats(200±20g)were randomly divided into blank group,model group,Metoprolol group and DJFM group.Ten rats in each group were fed with normal diet and free drinking water.Each group was given gavage,and the amount of gavage in each group was calculated according to body weight.In the model group,0.001%Aconitine was injected into the tail vein at 30ug/kg.In the Metoprolol group,Metoprolol suspension was given according to the standard of 5.2mg/kg per day.In the DJFM group,DJFM was given at 17.6g/kg per day.After 2 weeks of administration,the biologic experiment system BL-420F was used to monitor the II lead ECG curve,and the ECG changes were observed and recorded.Then,the left ventricle of the rat was taken,and part of the heart tissue sodium potassium pump was detected.Results:(1)The effect of DJFM on ECG of rats with ventricular arrhythmia:After intravenous injection of aconitine,the incidence of Ventricular Premature beat(VP),Ventricular Tachycardia(VT),Ventricular Fibrillation(VF)in the model group was 100%,suggesting that the model building of rats with ventricular arrhythmia was successful.(2)VP,VT,and VF time:Compared with model group,DJFM group and Metoprolol group can significantly delay the VP,VT and VF,the difference was statistically significant(P<0.05).The effect of DJFM group and Metoprolol group on delaying the appearance of VP,VT and VF was the same,there was no significant difference(P>0.05).(3)The effect of DJFM on sodium potassium pump in rat ventricular arrhythmia heart tissues:Compared with the blank group,the sodium potassium pump value in the model group was significantly decreased,and the difference was statistically significant(P<0.05).Compared with the model group,the sodium potassium pump value of the tissues in the Metoprolol group and the DJFM group increased,and the difference was statistically significant(P<0.05).There was no significant difference in sodium potassium pump between the Metoprolol group and the DJFM group(P>0.05).Conclusion:1.The rat model of ventricular arrhythmia can be successfully prepared by intravenous injection of Aconitine.2.DJFM can prolong the occurrence time of cardiac arrhythmias caused by aconitine in rats,such as VP,VT,VF,et al.The mechanism may be related to fast Na^+channel,and it may prevent and control arrhythmias by inhibiting Na^+influx and reducing the fast response cellular self-discipline.3.DJFM can protect the myocardial tissue sodium potassium pump,which can protect the myocardial cells and improve the myocardial metabolism.

Effects of power-law spectrum behaviors of nonthermal electrons on a ring-beam maser instability

The electron-cyclotron maser （ECM） emission driven by nonthermal electrons is one of the most crucial mechanisms responsible for radio emissions in magnetized planets, for the interplanetary medium （IPM） and for the laboratory microwave generation devices. Major astrophysical observations demonstrate that nonthermal electrons frequently have a negative power-law spectrum with a lower energy cutoff and anisotropic distribution in the velocity space. In this paper, the effects of power-law spectrum behaviors of electrons on a ring-beam maser emission are considered. The results show that the growth rates of O1 and X2 modes decrease rapidly for small A （the dispersion of momentum u）. Because of the lower energy cutoff behavior, the nonthermal electrons with large a still can excite the ECM instability efficiently. The present analysis also includes the effects of parameter β （βu0 is the dispersion of perpendicular momentum ui, u0 the average value of u） on the instability. The growth rate of X2 mode decreases with parameter v0 （v0 = u⊥o/uo, U⊥0 is the average value of u⊥）. But for O1 mode, the relationship between the growth rate and v0 is complicated. It also shows that the growth rates are very sensitive to frequency ratio Ω （frequency ratio of electron cyclotron frequency to plasma frequency）.