基于柔性压力传感器的手套式脉诊传感装置的设计

目的:设计一种基于柔性压力传感器的手套式脉诊传感装置,以解决脉诊中“在心易了,指下难明”的困境。方法:该装置由便携式电阻检测装置与封装有柔性压力传感器的手套组成,其中便携式电阻检测装置基于集成电路技术搭建,由单片机、电源管理模块、AD7793阻抗测试模块、蓝牙通信模块、滤波模块和外围电路组成;采用微纳加工技术和柔性电子技术制备柔性压力传感器并将其贴敷于手套上,通过检测柔性压力传感器的电阻变化实现脉象的实时检测。结果:该装置检测结果与中医脉诊结果相同,不仅可以准确地测量出符合中医脉象记录的脉搏波,还可以准确地提取出回波等信号,并可以得出脉力和脉率等信息。结论:该装置结构紧凑、便于携带,脉象检测灵敏度、准确度高,脉象信息丰富,可以用于中医脉象的检测。

多光束干涉光纤FP探针脉动微压传感研究

本文提出一种面向脉动微压传感的多光束干涉光纤法布里-珀罗(FP)探针。建立探针多光束干涉波长漂移与微压传感模型,分析其在气、液相环境中微压灵敏度差异。采用化学腐蚀、放电熔接、精密切割技术制备光纤探针器件。利用医用注射器、透明柔性软管、石英插芯构建微压测试环境,通过有限元仿真分析测试环境内部压强分布情况,在气相环境压强范围14.41~85.22 kPa、液相环境压强范围4.50~26.02 kPa的测试条件下,对3支光纤探针微压传感特性进行分析。实验结果表明,气、液相环境中,探针波长均随压强增大发生红移现象,反之,发生蓝移现象;气相环境探针平均微压灵敏度可达8.210 pm·kPa,液相环境探针平均微压灵敏度可达66.720 pm·kPa,高于气相环境,与理论模型相符。选取气、液相环境中微压灵敏度最高的光纤探针进行液相脉动微压传感特性研究。实验结果表明,5个脉动周期内探针波长响应良好,且重复性误差较小。本文提出的光纤探针结构紧凑,易于制备,灵敏度高,可实现1 Hz频率范围内的脉动微压传感,为液相环境脉动微压传感提供了重要的参考价值。

志意脉象诊断与儿科病证实践

伴随精神行为病证志意辨证理论与方药体系的实践应用,相应的志意脉象诊法需要构建;临床脉学研读体会,单因素、典型脉象的感悟须从重视儿科开始。病证、体质、志意脉象的拾取与诊断技能提升,应秉承中医传统脉学理法,学习汲取现代脉家精华,注重脉感的训练与研习,区分疾病类属,选择相宜脉诊方法,依据脉征特点,选择相宜脉诊指法,顺应脉象规律,选择相宜脉诊层位。

不同脉宽的超宽谱电磁脉冲对细导线的耦合

利用时域有限差分(FDTD)方法,分别对不同脉冲宽度的超宽谱电磁脉冲在自由空间中的不同长度的细导线上的感应电流进行了计算。计算结果表明:不同脉冲宽度的超宽谱电磁脉冲,在同一根细导线上所感应电流的幅值大小和波形曲线有明显不同,细导线的长度化也会产生类似现象,也就是说超宽谱电磁脉冲在细导线上的感应电流是同时和脉冲宽度和细导线长度相关的,即不同的长度对应不同的易感脉宽,同时这种相关也是有一定的规律可循的。

Community-based Survey of Prevalence and Risk Factors of Syphilis among Injection Drug Users in Sichuan Province, China

Objectives: To investigate prevalence and risk fac-tors of syphilis infection among injection drug users(IDUs) in Lianshan Yizu Autonomous Region ofSichuan province, China.Methods: From November 8th 2002 to November29th 2002, a community-based cross-sectional surveywas conducted to investigate the demographic charac-teristics and sexual behaviors of a population of IDUs.Blood samples were collected to test for syphilisinfection. A total of 379 subjects were recruitedfor the study through community outreach and peerrecruiting methods.Results: Of 379 IDUs, the syphilis prevalence amongIDUs was 15.3% (58/379). Gender, years of education,history of unprotected sex with non-steady sex part-ner in the last month, number of sex partners in thelast 6 months, frequency of sex with non-steady sexpartner in the last 6 months, and number of any newsex partner(s) in the last 6 months were associatedwith syphilis infection after univariate analysis usingthe chi-squared test. Multivariate logistic regressionanalysis showed that ethnicity (OR, 2.85; 95% CI,1.55-5.25), marriage (OR, 1.94; 95% CI, 1.04-3.62)and receiving money for sex in the last 6 months (OR, ,5.60; 95% CI, 2.65-11.85) were significantly associ-ated with syphilis infection among IDUs.Conclusions: This study found that receiving moneyfor sex in the last 6 months was significantly associ-ated with syphilis prevalence among IDUs. It isrecommended that further health education andintervention campaigns be focused on IDUs to promotesafe sexual practices.

Contribution of Adventitious Roots to Water Use Strategy of Juniperus sabina in a Semiarid Area of China

duniperus sabina Linnaeus, an evergreen shrub with prostrate life form, can effectively prevent sand moving and is an important tree species for reforestation in semiarid areas of China. It has laterally distributed adventitious roots and a deeply distributed main root system. To detect water movement between the main root system and adventitious roots, we adopted heat pulse sensors using the Heat Ratio Method, a high precision method for measuring low sap flow rates. Two sensors were implanted in each individual in the stem between the main root system and adventitious roots, and another two in lateral stems distal to all the roots. Positive sap flows during nighttime, even under saturated air moisture conditions, were detected only between the main root system and adventitious roots under drought conditions, and the rate of flow increased as drought progressed and decreased or disappeared after rain events. The results demonstrated the existence of water movement from the main root system to adventitious roots, and combined with the high contribution of nighttime sap flow to transpiration （11%-16%） the results indicate that it also involves the process of hydraulic lift, a water movement from moist subsoil to dry surface soils. Integrated water use strategy between the main root system and adventitious roots via the process of hydraulic lift of soil water maximizes water acquisition efficiency from both subsoil water and water from rain pulses on the soil surface; this increases survivability in the water-limited environment of semiarid areas.

Hepatitis B virus infection and coronary atherosclerosis: Results from a population with relatively high prevalence of hepatitis B virus

AIM: To investigate the possible association between hepatitis B virus (HBV) infection and angiographically proven coronary artery disease (CAD) in a population with relatively high prevalence of HBV.METHODS: Sera from 434 patients who underwent coronary angiography were tested for HBV antigens (HBsAg, HBeAg) and antibodies (Anti-HBs, Anti-HBc and Anti-HBe) by ELISA.RESULTS: Seventy-seven percent (224/291) of the patients with CAD and 73.4% (105/143) of the patients without angiographic evidence of atherosclerosis were seropositive for HBV (P＞0.05). However, C-reactive protein (CRP) levels were significantly higher in patients with CAD (P = 0.008), while lower in HBV seropositive population (P= 0.043 and P = 0.021 after adjustment for conventional risk factors).CONCLUSION: Our results suggested HBV infection negatively correlates with CRP levels, but seems not to be associated with coronary atherosclerosis.

Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis

AIM:To investigate the anti-oxidative and anti-fibrotic effects of aloe vera in patients with liver fibrosis.METHODS:Aloe vera high molecular weight fractions(AHM) were processed by patented hyper-dry system in combination of freeze-dry technique with microwave and far infrared-ray radiation.Fifteen healthy volunteers as the control group and 40 patients were included.The patients were randomly subdivided into two equal groups:the conventional group was treated with placebo(starch),and AHM group was treated with 0.15 gm/d AHM,both for 12 consecutive weeks.The patients were investigated before and after treatment.Serum activity of aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkaline phosphatase(ALP),hyaluronic acid(HA),transforming growth factor-β(TGF-β) and matrixmetalloproteinase-2(MMP-2) were determined.The reduced glutathione(GSH) and malondialdehyde(MDA) levels in liver were assayed and the expression of hepatic α-smooth muscle actin(α-SMA) was identified by immunohistochemistry.RESULTS:At the start of the study,the hematoxylin and eosin staining revealed fibro-proliferated bile ductules,thick fibrous septa and dense inflammatory cellular infiltration in the patients before treatment.The use of AHM for 12 wk significantly ameliorated the fibrosis,inhibited the inflammation,and resulted in minimal infiltration and minimal fibrosis compared to the conventional group.The enzyme activities of the liver(ALT,AST and ALP) were attenuated after treatment in both groups,and the decrease in the AHM group was more significant as compared with the conventional group.Similar to the AST,the MDA levels were significantly higher before treatment,and were attenuated after treatment in both groups.In contrast,the hepatic glutathione content in the patients were decreased significantly in the AHM group compared to the controls.The serum levels of the fibrosis markers(HA,TGF-β and MMP-2) were also reduced significantly after treatment.The expression of α-SMA was modified in patients before and after treatment as compared with the normal controls.In the conventional group,there was only thin and incomplete parenchymal α-SMA positive septum joining the thickened centrilobular veins,while in the AHM group,few α-SMA positive cells were present in sinusoid and lobule after treatment.CONCLUSION:Oral supplementation with AHM could be helpful in alleviating the fibrosis and inflammation of hepatic fibrosis patients.

The application of anterolateral thigh flap in post-operative repairing of vulva tumor

Objective： The aim of this study was to evaluate the value of the application of anterolateral thigh flap in postoperative repairing of vulva tumor. Methods： Anterolateral thigh flap with the descending branch of the lateral circumflex femoral artery and the pedicle of anterolaterat thigh cutaneous nerve was used in primary repairing of the defect from postoperative vulva tumor, the sizes of the flaps ranged from 10 cm ×14 cm-14 cm× 20 cm. Results： All flaps survived, during a follow-up of 2 to 12 months, the appearance of the flaps was satisfactory with sensitive function without local recurrences. Conclusion： Anterelateral thigh flap has fairly long vessel pedicle, wider vessel diameter, and is in the covert area. Anterolateral thigh flap with sensory nerve is the ideal choice for postoperative repairing of vulva tumor.

LA-ICP MS Characteristic of Geochemical Composition of Veins Rocks from the Central Part of the Khibina Massive in Kola Peninsula, Northern Russia

This paper discusses the vein rocks located in the central part of Khibina Mts.. These rocks are located on the border of two zones： ore and external. In the ore, zone is present titanite-nepheline bodies whilst in the outer zone are massive-syenites ＂khibinites＂. The veins can be divided into： mikrosyenites, melteigites and other rock types （e.g., tinguaites）. The results of LA-ICP MS （laser ablation of inductively coupled plasma mass spectrometry） indicate that these rocks are associated with deep zones which formed as a result of injection of primary magma and contamination of fluids during migration, where there have hydrothermal processes. Rock-forming minerals, their corrosion and accessory minerals indicate these processes, too.

Flow characteristics of variable hydraulic transformer

A new kind of hydraulic transformer, called variable hydraulic transformer(VHT), is proposed to control its load flow rate. The hydraulic transformer evolves from a pressure transducer to a power transducer. The flow characteristics of VHT, such as its instantaneous flow rates, average flow rates, and flow pulsations in the ports, are investigated. Matlab software is used to simulate and calculate. There are five controlled angles of the port plate that can help to define the flow characteristics of VHT. The relationships between the flow characteristics and the structure in VHT are shown. Also, the plus-minus change of the average flow rates and the continuity of the instantaneous flow rates in the ports are presented. The results demonstrate the performance laws of VHT when the controlled angles of the port plate and of the swash plate change. The results also reveal that the special principle of the flow pulsation in the ports and the jump points of the instantaneous curves are the two basic causes of its loud noise, and that the control angles of the port plate and the swash plate and the pressures in the ports are the three key factors of the noise.

Sensitivity of Some Biological Objects to Repetitive Submicrosecond Microwave Pulses

The effect of repetitive pulsed microwaves （10 GHz, pulse duration of 100-300 ns, pulse repetition rate of 4-25 pulse per second, peak power density of 0.04-3.5 kW/cm^2） on mastocytoma P815, Ehrlich carcinoma, normal spleen cells and wound healing was investigated. It was found that short-time irradiation with an intensity of 0.9-1.5 kW/cm^2 inhibited proliferation of tumor cells in vitro, whereas at same time it contributes to proliferation of normal spleen cells in vitro. The repetitive pulsed microwaves with an intensity of 0.04-1.5 kW/cm^2 stimulated healing of skin wounds and ulcerations in mice. The effects showed a dependence on the pulse repetition rate and irradiation intensity.

PULSE CUMULATING METHOD FOR MULTI-TARGETS' JOINT AZIMUTH-ELEVATION FREQUENCY-DELAY ESTIMATION

The Directions of Arrivals （DOAs）, speeds and distances of targets are all required for array signal processing. Based on the periodic phase shift of coherent pulse sequence waveform, a new estimation of multi-targets＇ 2-Dimentional （2-D） DOA angle, Doppler frequency shift and relative time-delay is proposed. Based on a virtual sensor array constructed by pulse cumulating, the estinaations of azimuth, elevation, Doppler frequency shift and time-delay can be obtained simultaneously, and the least number of pulses could be two. This method is computationally efficient even in heavier noised environment, and all estimations are automatically paired in calculation process with no used to any plane sensor array and deal with many spectrum searching. Further more, this algorithm can be targets at the same time only by few sensors. The targets number that can deal with simultaneously is several times to the sensor number, which is the upper limit for normal algorithms such as ESPRIT and MUSIC. These characteristics would be very useful, especially, for aerial systems. Simulations demonstrate the capabilities of this method efficiently.

Transjugular intrahepatic portosystemic shunt in liver transplant recipients

AIM： To evaluate the efficacy of transjugular intrahepatic portosystemic shunts （TIPSs） after liver transplantation （LT）. METHODS： Between November 1996 and December 2005, 10 patients with severe recurrent hepatitis C virus infection （n = 4）, ductopenic rejection （n = 5） or portal vein thrombosis （n = 1） were included in this analysis. Eleven TIPSs （one patient underwent two TIPS procedures） were placed for management of therapy-refractory ascites （n = 7）, hydrothorax （n = 2） or bleeding from colonic varices （n = 1）. The median time interval between LT and TIPS placement was 15 （4-158） mo. RESULTS： TIPS placement was successful in all patients. The mean portosystemic pressure gradient was reduced from 12.5 to 8.7 mmHg. Complete and partial remission could be achieved in 43% and 29% of patients with ascites. Both patients with hydrothorax did not respond to TIPS. No recurrent bleeding was seen in the patient with colonic varices. Nine of 10 patients died during the study period. Only one of two patients, who underwent retransplantation after the TIPS procedure, survived. The median survival period after TIPS placement was 3.3 （range 0.4-20） too. The majority of patients died from sepsis with multiorgan failure. CONCLUSION： Indications for TIPS and technical performance in LT patients correspond to those in non-transplanted patients. At least partial control of therapy-refractory ascites and variceal bleeding could be achieved in most patients. Nevertheless, survival rates were disappointing, most probably because of the advanced stages of liver disease at the time of TIPS placement and the high risk of sepsis as a consequence of immunosuppression.

Quantitative assessment of sensory functions after 3 surgical approaches for trigeminal neuralgia by current perception threshold measurement

Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perception threshold measurement （CPTM）. Methods： In the current study, there were 48 trigeminal neuralgia patients without history of prior surgical treatment. These patients received one of the following 3 surgical procedures, microvascular decompression （MVD）, peripheral nerve block with alcohol （PNB）, or percutaneous radiofrequency thermocoagulation （PRFT）. The quantitative sensory testing measurement, CPTM, and conventional qualitative sensory testing measurements were performed preoperatively and postoperatively to evaluate and grade the trigeminal sensory functions All 3 major cutaneous sensory fiber types, large myelinated fibers （A beta）, small myelinated fibers （A delta） and unmyelinated fibers（C） were allowed to quantitatively evaluate and grade by CPTM. The results of the measurements were statistically analyzed using a one-way analysis of variance （single factor）. Each subject was his/her own control for comparison of the preoperative to postoperative state on the asymptomatic and symptomatic sides. Subjects were tested 48 h preoperatively and 4 weeks postoperatively. Results： PNB with alcohol and PRFT caused significant sensory dysfunction postoperatively in every fiber type, indicating damage to all fibers. On the contrary, the sensory function in all 3 fiber types was unchanged after MVD management. Conclusion： Among the 3 major surgical procedures tested, only MVD preserves sensory function in trigeminal system. CPTM is of quantitative nature on the evaluation of sensory functions of nerve fibers

Family care and subjective well-being of coronary heart disease patients after percutaneous coronary intervention:Mediating effects of coping strategies

Objectives To analyze the correlations between family care,coping strategies and the subject well-being(SWB)of patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods From November 2019 to October 2020,264 CHD patients who had undergone PCI were enrolled in this questionnaire survey.The research tools applied included General Information Questionnaire,the Adaptation,Partnership,Growth,Affection and Resolve,Medical Coping Modes Questionnaire,and the General Well-being Schedule.SPSS 24.0 and Amos 23.0 software packages were used for statistical analysis.Results The mean scores for family care,confrontation,avoidance,acceptance-resignation and SWB,were 7.59±2.24,20.03±3.78,16.49±2.70,10.42±2.01,and 73.31±11.63,respectively.Subgroup analysis showed that the path coefficient between family care and subjective well-being was higher in males than females.Family care was directly related to coping strategies.The coping strategies were directly related to SWB,while family care showed an indirect association with SWB via coping strategies.Conclusions Family care can improve CHD patients’SWB post-PCI,and coping strategies are important for the link between family care and SWB.Also,men received more family care than women.Based on a patient's characteristics,healthcare providers can promote patients’positive coping strategies,increase their perceived family care,and improve the patient's SWB.

Prophylactic antibiotics for variceal hemorrhage: Clostridium difficile infection still can be a risk

Bron et al presented a retrospective study regarding the prophylactic use of antibiotics for variceal hemorrhage. Antibiotics appeared to improve the survival rate of patients without increasing clostridium difficile infection (CDI). We argue against the conclusion of the authors and consider that this result may be simply due to concurrent use of metronidazole, a therapeutic agent against CDI.

Quantitative analysis of plasma HBV DNA for early evaluation of the response to transcatheter arterial embolization for HBV-related hepatocellular carcinoma

AIM： To assesse changes in plasma HBV DNA after TAE in HBV-related HCC and correlate the levels with the pattern of lipiodol accumulation on CT. METHODS： Between April and June 2001, 14 patients with HBV-associated HCC who underwent TAE for inoperable or recurrent tumor were studied. Levels of plasma HBV DNA were measured by real-time quantitative PCR daily for five consecutive days after TAE. More than twofold elevation of circulating HBV DNA was considered as a definite elevation. Abdominal CT was performed 1-2 mo after TAE for the measurement of lipiodol retention. RESULTS： Circulating HBV DNA in 10 out of 13 patients was elevated after TAE, except for one patient whose plasma HBV DNA was undetectable before and after TAE. In group Ⅰ patients （n = 6）, the HBV DNA elevation persisted for more than 2 d, while in group Ⅱ （n = 7）, the HBV DNA elevation only appeared for i d or did not reach a definite elevation. There were no significant differences in age or tumor size between the two groups. Patients in group Ⅰ had significantly better lipiodol retention （79.31±28.79%） on subsequent abdominal CT than group Ⅱ （18.43±10.61%） （P = 0.02）. CONCLUSION： Patients with durable HBV DNA elevation for more than 2 d correlated with good lipiodol retention measured 1 mo later, while others associated with poor lipiodol retention. Thus, circulating HBV DNA may be an early indicator of the success or failure of TAE.

Patient-controlled intravenous fentanyl for cystospasm after transurethral resection of the prostate

Objective： To evaluate the clinical efficacy and safety of patient-controlled intravenous analgesia （PCIA） with fentanyl for cystospasm after transurethral resection of the prostate. Methods： Sixty benign prostatic hyperplasia （BPH） patients scheduled for transurethral resection of the prostate （TURP） under general anesthesia with laryngeal mask airway （LMA） were randomly divided into groups F and S. Group F （n=30） received PCIA device with fentanyl 10 ug/kg＋8 mg ondansetron, and Group S （n=30） received placebo （PCIA device with 8 mg ondansetron）. The visual analog scale （VAS） scores for pain were evaluated at 0, 2, 4, 8, 16, 24, and 48 h by the same staff. And recorded were incidence of cystospasm, side effects, application of hemostatic, duration of drawing Foley catheter and continuous bladder irrigation, time of exhaust after operation, time of post-operative stay and cost of hospitalization. Results： The incidence of cystospasm in Group F was significantly lower than that in Group S in the 48 h after operation （P〈0.05）, the VAS scores for pain in Group F was significantly lower than that in Group S within the 48 h after operation （P〈0.01）. The time of exhaust after operation in Group F was significantly later than in Group S （P〈0.05）. No significant difference was observed in applications of hemostatic, duration of drawing Foley catheter, duration of continuous bladder irrigation, time of post-operative stay and cost of hospitalization between the 2 groups. Conclusion： PCIA with fentanyl （10 ug/kg） relieves pain with little side effect and reduces cystospasm satisfactorily.

The Influence of Generated Pulses Parameters on the Thyratron in the Inductive Energy Storage

Experimental research of anode current and anode voltage influence on the speed of decaying plasma resistance change and the time ofthyratron cutoff. Anode current resistance increase is shown to cause thyratron cutoff time increase in case of fixed anode voltage. In turn anode voltage increase in case of fixed anode current causes earlier increase of decaying plasma resistance growth speed and quicker apparatus cutoff：