OBJECTIVE To evaluate the MR imaging features of solitary plasmacytomas of the spine. METHODS The MR images of 7 patients with histologically proven solitary plasmacytomas of the spine were reviewed. RESULTS All tumor...OBJECTIVE To evaluate the MR imaging features of solitary plasmacytomas of the spine. METHODS The MR images of 7 patients with histologically proven solitary plasmacytomas of the spine were reviewed. RESULTS All tumors showed predominantly isoto hypointensity relative to muscle on Tl-weighted MR images and intermediate signal intensity between muscle and fat on T2- weighted images. Curvilinear low signal intensity structures were seen within the lesions on T1 and T2-weighted images in five tumors. Moderate to strong enhancement was seen in all 6 tumors that underwent contrast enhanced MR examination. All tumors showed areas of high signal intensity on T2-weighted images and heterogeneous enhancement, except the 2 largest tumors without pathologic fracture in the sacrum. Intervertebral discs were preserved in all tumors. CONCLUSION The MR imaging features that suggest plasmacytorna of the spine include predominant intermediate signal intensity on T2-weighted images, curvilinear low signal intensity structures, moderate to strong enhancement, relatively homogeneous appearance if there are no pathologic fracture and preservation of the intervertebral discs.展开更多
Objective： To investigate the expression level of E-cadherin in spinal plasma cell myeloma and its relationship with the clinicopathological indexes of spinal plasma cell myeloma. Methods： The expression of E-cadher...Objective： To investigate the expression level of E-cadherin in spinal plasma cell myeloma and its relationship with the clinicopathological indexes of spinal plasma cell myeloma. Methods： The expression of E-cadherin was detected in 41 cases of spinal plasma cell myeloma and 14 cases of simple bone cysts by using S-P （streptavidin-perosidase） immunohistochemical staining. The relationship between E-cadherin expression and the clinicopathological features was analyzed. Results： In spinal plasma cell myelomas, the positive expression rate of E-cadherin （46.34%） was higher than that in simple bone cyst tissues （all negative） （P〈0.01）. And the expression of E-cadherin had no obvious relationship with patients＇ age, gender, clinical classification or M-component （P〉0.05）, but had relationship with the classification of light chain. The expression rate in lambda chain subgroup was lower than that in the others （P〈0.05）. We also found the E-cadherin negative patients had a higher overall survival rate than those who had strong E-cadherin expression （P〈0.05）. Conclusion： E-cadherin expressed higher in spinal plasma cell myelomas than in simple bone cyst tissues and its expression had relationship with the light chain classification in spinal plasma cell myeloma. The patients with no stain of E-cadherin may have a poor prognosis. Detecting the type of light chain associated with expression of E-cadherin might be helpful in evaluating the outcome of spinal PCM patients.展开更多
文摘OBJECTIVE To evaluate the MR imaging features of solitary plasmacytomas of the spine. METHODS The MR images of 7 patients with histologically proven solitary plasmacytomas of the spine were reviewed. RESULTS All tumors showed predominantly isoto hypointensity relative to muscle on Tl-weighted MR images and intermediate signal intensity between muscle and fat on T2- weighted images. Curvilinear low signal intensity structures were seen within the lesions on T1 and T2-weighted images in five tumors. Moderate to strong enhancement was seen in all 6 tumors that underwent contrast enhanced MR examination. All tumors showed areas of high signal intensity on T2-weighted images and heterogeneous enhancement, except the 2 largest tumors without pathologic fracture in the sacrum. Intervertebral discs were preserved in all tumors. CONCLUSION The MR imaging features that suggest plasmacytorna of the spine include predominant intermediate signal intensity on T2-weighted images, curvilinear low signal intensity structures, moderate to strong enhancement, relatively homogeneous appearance if there are no pathologic fracture and preservation of the intervertebral discs.
文摘Objective： To investigate the expression level of E-cadherin in spinal plasma cell myeloma and its relationship with the clinicopathological indexes of spinal plasma cell myeloma. Methods： The expression of E-cadherin was detected in 41 cases of spinal plasma cell myeloma and 14 cases of simple bone cysts by using S-P （streptavidin-perosidase） immunohistochemical staining. The relationship between E-cadherin expression and the clinicopathological features was analyzed. Results： In spinal plasma cell myelomas, the positive expression rate of E-cadherin （46.34%） was higher than that in simple bone cyst tissues （all negative） （P〈0.01）. And the expression of E-cadherin had no obvious relationship with patients＇ age, gender, clinical classification or M-component （P〉0.05）, but had relationship with the classification of light chain. The expression rate in lambda chain subgroup was lower than that in the others （P〈0.05）. We also found the E-cadherin negative patients had a higher overall survival rate than those who had strong E-cadherin expression （P〈0.05）. Conclusion： E-cadherin expressed higher in spinal plasma cell myelomas than in simple bone cyst tissues and its expression had relationship with the light chain classification in spinal plasma cell myeloma. The patients with no stain of E-cadherin may have a poor prognosis. Detecting the type of light chain associated with expression of E-cadherin might be helpful in evaluating the outcome of spinal PCM patients.
