Objective To observe the clinical effect on cervical spondylosis of nerve root type treated by warm needling therapy at Jiáj （夹脊 EX-B 2） and plum-blossom needle therapy. Methods According to the random number...Objective To observe the clinical effect on cervical spondylosis of nerve root type treated by warm needling therapy at Jiáj （夹脊 EX-B 2） and plum-blossom needle therapy. Methods According to the random number table, 150 cases of cervical spondylosis of nerve root type were randomized into an acupuncture-moxibustion group （75 cases） and a control group （75 cases）. In the acupuncture-moxibustion group, the warm needling at EX-B 2 and tapping with plum-blossom needle were applied. EX-B 2 on the affected segments were selected and stimulated with warm needling technique for 20– 30 min. Afterward, the plum-blossom needle was used to tap the skin around the acupoints, for 3 min on each site. The treatment was given once every day. Seven treatments made one session. The interval between two sessions was 1 day. In the control group, the medication was used in combination with traction therapy. The intravenous drip with 5% glucose 250 mL and compound salvia miltiorrhiza injection 40 mL was used, once a day. In traction treatment, the patient was in a sitting position, neck anteflexion at 15°–30°, traction force at 10%–20% of the body mass, for 20–30 min in each time. The treatment was given once every day. The appointed person evaluated therapeutic effects after the three sessions of treatment in the two groups. Results The clinical curative rate was 49.3% （37/75） and the total effective rate was 94.7% （71/75） in the acupuncture-moxibustion group and those were 24.0% （18/75） and 81.3% （61/75） respectively in the control group. The total effective rate and clinical curative rate in the acupuncture-moxibustion group were superior to the control group （both P0.05）. In the comparison of the duration of treatment and effect in the cured patients between the two groups, the curative rate in the 1st session of treatment in the acupuncture-moxibustion group was higher than that in the control group （P0.05）. In the comparison of the 6-month follow-up visit in the cured patients between the two groups, the effect in the acupuncture-moxibustion group was much more stable （P0.05）. Conclusion The warm needling therapy at EX-B 2 and tapping therapy with plum-blossom needle achieve the significant effect on cervical spondylosis of nerve root type.展开更多
Fibroblast growth factors (FGFs) can be classified as secretory (FGFI-10 and FGF15-23) or intracellular non-secretory forms (FGF 11-14). Secretory forms of FGF and their receptors are best known for their regulatory r...Fibroblast growth factors (FGFs) can be classified as secretory (FGFI-10 and FGF15-23) or intracellular non-secretory forms (FGF 11-14). Secretory forms of FGF and their receptors are best known for their regulatory roles in cell growth, differentiation and morphogenesis in the early stages of neural development. However, the functions of intracellular FGFs remain to be ex- plored. FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neu- rons. FGF13 is expressed in primary sensory neurons, and is colocalized with sodium channels at the nodes of Ranvier along the myelinated afferent fibers. FGF13 is also expressed in cerebral cortical neurons during the late developmental stage. A re- cent study showed that FGFI3 is a microtubule-stabilizing protein required for regulating the neuronal development in the cerebral cortex. Thus, non-secretory forms of FGF appear to have important roles in the brain, and it would be interesting to further investigate the functions of intracellular FGFs in the nervous system and in neural diseases.展开更多
文摘Objective To observe the clinical effect on cervical spondylosis of nerve root type treated by warm needling therapy at Jiáj （夹脊 EX-B 2） and plum-blossom needle therapy. Methods According to the random number table, 150 cases of cervical spondylosis of nerve root type were randomized into an acupuncture-moxibustion group （75 cases） and a control group （75 cases）. In the acupuncture-moxibustion group, the warm needling at EX-B 2 and tapping with plum-blossom needle were applied. EX-B 2 on the affected segments were selected and stimulated with warm needling technique for 20– 30 min. Afterward, the plum-blossom needle was used to tap the skin around the acupoints, for 3 min on each site. The treatment was given once every day. Seven treatments made one session. The interval between two sessions was 1 day. In the control group, the medication was used in combination with traction therapy. The intravenous drip with 5% glucose 250 mL and compound salvia miltiorrhiza injection 40 mL was used, once a day. In traction treatment, the patient was in a sitting position, neck anteflexion at 15°–30°, traction force at 10%–20% of the body mass, for 20–30 min in each time. The treatment was given once every day. The appointed person evaluated therapeutic effects after the three sessions of treatment in the two groups. Results The clinical curative rate was 49.3% （37/75） and the total effective rate was 94.7% （71/75） in the acupuncture-moxibustion group and those were 24.0% （18/75） and 81.3% （61/75） respectively in the control group. The total effective rate and clinical curative rate in the acupuncture-moxibustion group were superior to the control group （both P0.05）. In the comparison of the duration of treatment and effect in the cured patients between the two groups, the curative rate in the 1st session of treatment in the acupuncture-moxibustion group was higher than that in the control group （P0.05）. In the comparison of the 6-month follow-up visit in the cured patients between the two groups, the effect in the acupuncture-moxibustion group was much more stable （P0.05）. Conclusion The warm needling therapy at EX-B 2 and tapping therapy with plum-blossom needle achieve the significant effect on cervical spondylosis of nerve root type.
基金supported by the National Natural Science Foundation of China (Grant Nos. 31130066 and 30630029)National Basic Research Program of China (Grant Nos. 2011CBA00400 and 2009CB522005)Strategic Priority Research Program (B) of Chinese Academy of Sciences(Grant No. XDB02010200)
文摘Fibroblast growth factors (FGFs) can be classified as secretory (FGFI-10 and FGF15-23) or intracellular non-secretory forms (FGF 11-14). Secretory forms of FGF and their receptors are best known for their regulatory roles in cell growth, differentiation and morphogenesis in the early stages of neural development. However, the functions of intracellular FGFs remain to be ex- plored. FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neu- rons. FGF13 is expressed in primary sensory neurons, and is colocalized with sodium channels at the nodes of Ranvier along the myelinated afferent fibers. FGF13 is also expressed in cerebral cortical neurons during the late developmental stage. A re- cent study showed that FGFI3 is a microtubule-stabilizing protein required for regulating the neuronal development in the cerebral cortex. Thus, non-secretory forms of FGF appear to have important roles in the brain, and it would be interesting to further investigate the functions of intracellular FGFs in the nervous system and in neural diseases.
