目的:观察超声引导下内热针治疗脊神经后支源性腰痛的临床疗效。方法:2021年10月-2022年3月十堰市太和医院康复科收治的脊神经后支源性腰痛患者60例,随机分为两组,每组各30例。研究组采用超声引导腰脊神经后支支配区内热针治疗,对照组...目的:观察超声引导下内热针治疗脊神经后支源性腰痛的临床疗效。方法:2021年10月-2022年3月十堰市太和医院康复科收治的脊神经后支源性腰痛患者60例,随机分为两组,每组各30例。研究组采用超声引导腰脊神经后支支配区内热针治疗,对照组采用常规针刺疗法。行视觉模拟评分法(visual analog scale,VAS)、腰椎活动度评分评估两组患者在治疗后1 d、1周及6月的临床疗效,比较两组总有效率,并统计不良反应发生情况。结果:与对照组相比,研究组患者治疗后1周及6月后VAS评分显著降低(P<0.05);研究组治疗后6月腰椎活动度比对照组显著提高(P<0.05);研究组总有效率明显高于对照组(P<0.05)。两组患者均未见特殊并发症及不良反应。结论:超声引导下行内热针治疗能更有效地缓解疼痛,临床操作安全易行,疗效较好。展开更多
Objective To investigate the role of activated extracellular signal-regulated kinase 1/2 （ERK1/2） in spinal cord in the development of cystic pain in rabbit. Methods We observed the relationship between the activati...Objective To investigate the role of activated extracellular signal-regulated kinase 1/2 （ERK1/2） in spinal cord in the development of cystic pain in rabbit. Methods We observed the relationship between the activation of ERK1/2 in spinal cord and nociceptive behaviors, as well as the effect of U0126, a mitogen-activated protein kinase （MEK, upstream protein of ERK1/2） inhibitor, on cystic pain in rabbits by behavioral test, immunohistochemistry and western blot analysis. Results After injecting 0.5 ml formalin into gallbladder, the behaviors such as grasping of the cheek and licking of the abdomen increased in 30 min, with a significant increase in pERK1/2 expression in the spinal cord, as well as the pERK1/ 2 immunoreactive cells located in laminae Ⅴ-Ⅶ and X of the dorsal horn and ventral horn of T6 spinal cord. Administration of U0126 （100 -400 μg/kg body weight, i.v., 10 min before instillation of formalin） could attenuated nociceptive behaviors dose-dependently, but could not restrain the nociceptive behaviors completely even at the maximal efficient dose of 400 μg/kg body weight. Conclusion Activated ERK1/2 in the spinal cord at least partly participates in the development of acute inflammatory cystic pain induced by formalin in rabbits.展开更多
文摘目的:观察超声引导下内热针治疗脊神经后支源性腰痛的临床疗效。方法:2021年10月-2022年3月十堰市太和医院康复科收治的脊神经后支源性腰痛患者60例,随机分为两组,每组各30例。研究组采用超声引导腰脊神经后支支配区内热针治疗,对照组采用常规针刺疗法。行视觉模拟评分法(visual analog scale,VAS)、腰椎活动度评分评估两组患者在治疗后1 d、1周及6月的临床疗效,比较两组总有效率,并统计不良反应发生情况。结果:与对照组相比,研究组患者治疗后1周及6月后VAS评分显著降低(P<0.05);研究组治疗后6月腰椎活动度比对照组显著提高(P<0.05);研究组总有效率明显高于对照组(P<0.05)。两组患者均未见特殊并发症及不良反应。结论:超声引导下行内热针治疗能更有效地缓解疼痛,临床操作安全易行,疗效较好。
文摘Objective To investigate the role of activated extracellular signal-regulated kinase 1/2 （ERK1/2） in spinal cord in the development of cystic pain in rabbit. Methods We observed the relationship between the activation of ERK1/2 in spinal cord and nociceptive behaviors, as well as the effect of U0126, a mitogen-activated protein kinase （MEK, upstream protein of ERK1/2） inhibitor, on cystic pain in rabbits by behavioral test, immunohistochemistry and western blot analysis. Results After injecting 0.5 ml formalin into gallbladder, the behaviors such as grasping of the cheek and licking of the abdomen increased in 30 min, with a significant increase in pERK1/2 expression in the spinal cord, as well as the pERK1/ 2 immunoreactive cells located in laminae Ⅴ-Ⅶ and X of the dorsal horn and ventral horn of T6 spinal cord. Administration of U0126 （100 -400 μg/kg body weight, i.v., 10 min before instillation of formalin） could attenuated nociceptive behaviors dose-dependently, but could not restrain the nociceptive behaviors completely even at the maximal efficient dose of 400 μg/kg body weight. Conclusion Activated ERK1/2 in the spinal cord at least partly participates in the development of acute inflammatory cystic pain induced by formalin in rabbits.
