Event-related potentials (ERP) is an important type of brain dynamics in human cognition research. However, ERP is often submerged by the spontaneous brain activity EEG, for its relatively tiny scale. Further more, th...Event-related potentials (ERP) is an important type of brain dynamics in human cognition research. However, ERP is often submerged by the spontaneous brain activity EEG, for its relatively tiny scale. Further more, the brain activities collected from scalp electrodes are often inevitably contaminated by several kinds of artifacts, such as blinks, eye movements, muscle noise and power line interference. A new approach to correct these disturbances is presented using independent component analysis (ICA). This technique can effectively detect and extract ERP components from the measured electrodes recordings even if they are heavily contaminated. The results compare favorably to those obtained by parametric modeling. Besides, auto-adaptive projection of decomposed results to ERP components was also given. Through experiments, ICA proves to be highly capable of ERP extraction and S/N ratio improving.展开更多
Objective. To explore the changes of three- tone paradigm P300 and observe the improvement of the diagnostic sensitivity of P300 in aging dementia. Methods. Thirty- four patients of aging dementia underwent traditiona...Objective. To explore the changes of three- tone paradigm P300 and observe the improvement of the diagnostic sensitivity of P300 in aging dementia. Methods. Thirty- four patients of aging dementia underwent traditional P300 (2t- P300) and three- tone paradigm auditory P300 (3t- P300). The results of these two methods were compared. Results. Abnormal P300 was found in 18 of 34 dementia cases (52.9％ ) by 2t- P300, and in 26 of 30 patients who finished the 3t- P300 tests (86.7％ ). In 2t- P300, 9 of 24 mild cases, 7 of 8 moderate cases and 2 severe cases showed abnormal results. In 3t- P300, 20 of 24 mild cases and all 6 moderate cases showed abnormal results. Abnormal 3t- P300 was found in 13 of 16 cases which showed normal 2t- P300. Besides prolonged and bad- shaped P300, no certain response of P300 to rare non- target stimulus (r- nT) was found in 10 mild cases by 3t- P300. Conclusion. Three- tone paradigm auditory P300 had higher sensitivity in early diagnosis of aging dementia than traditional auditory P300. No P300 response to r- nT in 3t- P300 is an important index in early diagnosis of mild dementia.展开更多
Objective:To explore the mechanism of acupuncture in regulating cognitive deficits in insomnia rats by observing the effect of acupuncture on microglia in thalamic reticular nucleus(TRN).Methods:Thirty rats were rando...Objective:To explore the mechanism of acupuncture in regulating cognitive deficits in insomnia rats by observing the effect of acupuncture on microglia in thalamic reticular nucleus(TRN).Methods:Thirty rats were randomly divided into a control group,a model group and an acupuncture group,with 10 rats in each group.The insomnia model was established by intraperitoneal injection of para-chlorophenylalanine(PCPA)once a day for 2 d.Rats in the control group were intraperitoneally injected with the same amount of normal saline.Rats in the acupuncture group received acupuncture at Neiguan(PC 6)and Zusanli(ST 36)for 5 consecutive days.The CLOCKLAB 2 data acquisition system was used to dynamically observe the sleep of the rats throughout the experiment.The cognition of rats was evaluated by event-related potentials(ERPs).After intervention,brain tissue was extracted.Immunofluorescence was used to test the fluorescence expression in TRN region.The concentrations of interleukin(IL)-1βand tumor necrosis factor(TNF)-αwere detected by enzyme-linked immunosorbent assay.Results:After intraperitoneal injection of PCPA suspension,the spontaneous activity in light period of rats in the model group and acupuncture group increased significantly compared with the control group(both P<0.01).After acupuncture treatment,the rats in the acupuncture group had much less spontaneous activity during the light period than those in the model group(P<0.01),and the results indicated that acupuncture could effectively improve the sleep quality of insomnia rats.Compared with the control group,rats in the model group showed that the P3 latency,the average optical density of microglia,and the concentrations of IL-1βand TNF-αincreased significantly(all P<0.05),and the P3 amplitude decreased significantly(P<0.01).Compared with the model group,rats in the acupuncture group presented that the P3 latency,the average optical density of microglia,and the concentrations of IL-1βand TNF-αwere significantly decreased(all P<0.05),and the amplitude of P3 was significantly increased(P<0.05).Conclusion:Acupuncture possesses an ability to improve the cognitive state in insomnia rats.The mechanism may be related to inhibiting the microglial activation,diminishing the levels of pro-inflammatory mediators like IL-1βand TNF-α,and promoting the recovery of central nervous system function.展开更多
Brain mechanism of metaphor processing has always been a focus in Neurolinguistics. This study approaches bilinguals＇ metaphor semantic representation mechanism with Chinese bilinguals with different levels of second...Brain mechanism of metaphor processing has always been a focus in Neurolinguistics. This study approaches bilinguals＇ metaphor semantic representation mechanism with Chinese bilinguals with different levels of second language proficiency by means of ERP （Event-related Potentials） technology. The experiment results showed that： 1） Both hemispheres collaborate in metaphor processing with the left hemisphere serving a leading semantic recognition role. The left hemisphere is more sensitive to first language input, while the right hemisphere is more active to second language input. 2） Compared with Chinese learners of higher proficiency in L2, learners of lower proficiency tend to adopt more Chinese neural mechanism in processing English metaphors. 3） When learners process metaphors, the neural mechanism difference of learners of higher proficiency is smaller than that of those of lower proficiency. The higher the second language proficiency, the higher the degree of common representation of Chinese and English metaphor.展开更多
Objective：To observe and compare the therapeutic effect of two different needling methods,liver-soothing and mind-regulating needling method versus conventional needling method,in treating anxiety and depression in t...Objective：To observe and compare the therapeutic effect of two different needling methods,liver-soothing and mind-regulating needling method versus conventional needling method,in treating anxiety and depression in tension-type headache.Methods：A total of 120 patients with tension-type headache coupled with anxiety and/or depression were randomized into two groups according to the random number table,a liver-soothing andmind-regulating needling group （group A） and a conventional needling group （group B）,60 patients in each group.The self-rating anxiety scale （SAS） and self-rating depression scale （SDS） were used for evaluation before and after treatment.The therapeutic effects of the two groups were compared after 2-treatment courses.Results：The values of SAS and SDS both significantly dropped in the two groups （P0.01）,and the differences between the two groups after treatment were statistically significant （P0.01,P0.05）.The therapeutic effect in group A was superior to that in group B （P0.01）.The 3-month follow-up study showed that the liver-soothing andmind-regulating needling method had better long-term effect in improving anxiety and depression than the conventional needling method （P0.05）.Conclusion：The liver-soothing andmind-regulating needling method can effectively relieve the anxiety and depression symptoms in patients with tension-type headache,and the long-term effect is also satisfactory.展开更多
文摘Event-related potentials (ERP) is an important type of brain dynamics in human cognition research. However, ERP is often submerged by the spontaneous brain activity EEG, for its relatively tiny scale. Further more, the brain activities collected from scalp electrodes are often inevitably contaminated by several kinds of artifacts, such as blinks, eye movements, muscle noise and power line interference. A new approach to correct these disturbances is presented using independent component analysis (ICA). This technique can effectively detect and extract ERP components from the measured electrodes recordings even if they are heavily contaminated. The results compare favorably to those obtained by parametric modeling. Besides, auto-adaptive projection of decomposed results to ERP components was also given. Through experiments, ICA proves to be highly capable of ERP extraction and S/N ratio improving.
文摘Objective. To explore the changes of three- tone paradigm P300 and observe the improvement of the diagnostic sensitivity of P300 in aging dementia. Methods. Thirty- four patients of aging dementia underwent traditional P300 (2t- P300) and three- tone paradigm auditory P300 (3t- P300). The results of these two methods were compared. Results. Abnormal P300 was found in 18 of 34 dementia cases (52.9％ ) by 2t- P300, and in 26 of 30 patients who finished the 3t- P300 tests (86.7％ ). In 2t- P300, 9 of 24 mild cases, 7 of 8 moderate cases and 2 severe cases showed abnormal results. In 3t- P300, 20 of 24 mild cases and all 6 moderate cases showed abnormal results. Abnormal 3t- P300 was found in 13 of 16 cases which showed normal 2t- P300. Besides prolonged and bad- shaped P300, no certain response of P300 to rare non- target stimulus (r- nT) was found in 10 mild cases by 3t- P300. Conclusion. Three- tone paradigm auditory P300 had higher sensitivity in early diagnosis of aging dementia than traditional auditory P300. No P300 response to r- nT in 3t- P300 is an important index in early diagnosis of mild dementia.
文摘Objective:To explore the mechanism of acupuncture in regulating cognitive deficits in insomnia rats by observing the effect of acupuncture on microglia in thalamic reticular nucleus(TRN).Methods:Thirty rats were randomly divided into a control group,a model group and an acupuncture group,with 10 rats in each group.The insomnia model was established by intraperitoneal injection of para-chlorophenylalanine(PCPA)once a day for 2 d.Rats in the control group were intraperitoneally injected with the same amount of normal saline.Rats in the acupuncture group received acupuncture at Neiguan(PC 6)and Zusanli(ST 36)for 5 consecutive days.The CLOCKLAB 2 data acquisition system was used to dynamically observe the sleep of the rats throughout the experiment.The cognition of rats was evaluated by event-related potentials(ERPs).After intervention,brain tissue was extracted.Immunofluorescence was used to test the fluorescence expression in TRN region.The concentrations of interleukin(IL)-1βand tumor necrosis factor(TNF)-αwere detected by enzyme-linked immunosorbent assay.Results:After intraperitoneal injection of PCPA suspension,the spontaneous activity in light period of rats in the model group and acupuncture group increased significantly compared with the control group(both P<0.01).After acupuncture treatment,the rats in the acupuncture group had much less spontaneous activity during the light period than those in the model group(P<0.01),and the results indicated that acupuncture could effectively improve the sleep quality of insomnia rats.Compared with the control group,rats in the model group showed that the P3 latency,the average optical density of microglia,and the concentrations of IL-1βand TNF-αincreased significantly(all P<0.05),and the P3 amplitude decreased significantly(P<0.01).Compared with the model group,rats in the acupuncture group presented that the P3 latency,the average optical density of microglia,and the concentrations of IL-1βand TNF-αwere significantly decreased(all P<0.05),and the amplitude of P3 was significantly increased(P<0.05).Conclusion:Acupuncture possesses an ability to improve the cognitive state in insomnia rats.The mechanism may be related to inhibiting the microglial activation,diminishing the levels of pro-inflammatory mediators like IL-1βand TNF-α,and promoting the recovery of central nervous system function.
基金supported by China Foreign Language Education Research Fund under grant No.ZGWYJYJJ2016B79
文摘Brain mechanism of metaphor processing has always been a focus in Neurolinguistics. This study approaches bilinguals＇ metaphor semantic representation mechanism with Chinese bilinguals with different levels of second language proficiency by means of ERP （Event-related Potentials） technology. The experiment results showed that： 1） Both hemispheres collaborate in metaphor processing with the left hemisphere serving a leading semantic recognition role. The left hemisphere is more sensitive to first language input, while the right hemisphere is more active to second language input. 2） Compared with Chinese learners of higher proficiency in L2, learners of lower proficiency tend to adopt more Chinese neural mechanism in processing English metaphors. 3） When learners process metaphors, the neural mechanism difference of learners of higher proficiency is smaller than that of those of lower proficiency. The higher the second language proficiency, the higher the degree of common representation of Chinese and English metaphor.
文摘Objective：To observe and compare the therapeutic effect of two different needling methods,liver-soothing and mind-regulating needling method versus conventional needling method,in treating anxiety and depression in tension-type headache.Methods：A total of 120 patients with tension-type headache coupled with anxiety and/or depression were randomized into two groups according to the random number table,a liver-soothing andmind-regulating needling group （group A） and a conventional needling group （group B）,60 patients in each group.The self-rating anxiety scale （SAS） and self-rating depression scale （SDS） were used for evaluation before and after treatment.The therapeutic effects of the two groups were compared after 2-treatment courses.Results：The values of SAS and SDS both significantly dropped in the two groups （P0.01）,and the differences between the two groups after treatment were statistically significant （P0.01,P0.05）.The therapeutic effect in group A was superior to that in group B （P0.01）.The 3-month follow-up study showed that the liver-soothing andmind-regulating needling method had better long-term effect in improving anxiety and depression than the conventional needling method （P0.05）.Conclusion：The liver-soothing andmind-regulating needling method can effectively relieve the anxiety and depression symptoms in patients with tension-type headache,and the long-term effect is also satisfactory.
