目的观察颅内动脉粥样硬化与绝经后女性骨密度(bone mineral density,BMD)相关性。方法研究人群包括100名绝经后妇女,对受试者进行腰椎双能X线扫描,通过脑三维磁共振血管造影来评估受试者基底动脉、中脑、颅内颈内动脉和颅内椎动脉的粥...目的观察颅内动脉粥样硬化与绝经后女性骨密度(bone mineral density,BMD)相关性。方法研究人群包括100名绝经后妇女,对受试者进行腰椎双能X线扫描,通过脑三维磁共振血管造影来评估受试者基底动脉、中脑、颅内颈内动脉和颅内椎动脉的粥样硬化情况。T值<-1被定义为低骨量。所有分析均通过颅内动脉粥样硬化定位分层。结果 100名绝经后女性年龄范围为55~75岁。颅内动脉粥样硬化中颅内后循环(PC)动脉和颅内前循环(AC)动脉患病率分别为64%和67%。颅内动脉粥样硬化中AC与女性患者的低BMD相关。颅内动脉粥样硬化中PC的女性血磷水平显著升高,而T值显著低于颅内动脉粥样硬化中无PC的女性,高脂血症和低BMD在PC颅内动脉粥样硬化女性中更为常见,低BMD与PC中的颅内动脉粥样硬化显著相关。结论低BMD与女性亚临床颅内PC和AC动脉粥样硬化有关。展开更多
OBJECTIVE: To evaluate the value of perfusion MR imaging and angiographic evidence of collateral circulation in symptomatic patients with ischemic cerebrovascular diseases (ICVD). METHODS: Cerebral angiography and per...OBJECTIVE: To evaluate the value of perfusion MR imaging and angiographic evidence of collateral circulation in symptomatic patients with ischemic cerebrovascular diseases (ICVD). METHODS: Cerebral angiography and perfusion MR were performed in 16 patients with symptoms of ICVD. Qualitative perfusion maps were calculated for regional cerebral blood volume (rCBV) and mean transit time (MTT). RESULTS: A total of 27 lesions were seen on the perfusion MR maps (6 infarcts and 21 ischemic lesions) and most of them (26/27) showed a prolonged MTT. MTT is sensitive to the presence of ischemic lesions, but not sufficient in distinguishing infarct from ischemia. All of the infarcts showed a decreased rCBV, while most of the ischemic lesions showed a normal or increased rCBV. When collateral circulation was identified on angiography, most ischemic lesions were not infarcts and had a normal or increased rCBV. The absence of angiographically identifiable cerebral collaterals may not always result in an infarct; 50% had decreased rCBV. Despite the absence of angiographic collaterals, the other half had normal or increased rCBV. CONCLUSION: Cerebral angiographic evidence of collateral circulation is important in identifying a favorable outcome in patients with ICVD. However, a lesion with a normal or increased rCBV suggests a sufficient collateral circulation even without angiographic collaterals. Perfusion images may be a potentially useful adjunctive tool in the prediction of the outcome of ICVD, particularly where no apparent collateral macrocirculation is seen on CA.展开更多
文摘目的观察颅内动脉粥样硬化与绝经后女性骨密度(bone mineral density,BMD)相关性。方法研究人群包括100名绝经后妇女,对受试者进行腰椎双能X线扫描,通过脑三维磁共振血管造影来评估受试者基底动脉、中脑、颅内颈内动脉和颅内椎动脉的粥样硬化情况。T值<-1被定义为低骨量。所有分析均通过颅内动脉粥样硬化定位分层。结果 100名绝经后女性年龄范围为55~75岁。颅内动脉粥样硬化中颅内后循环(PC)动脉和颅内前循环(AC)动脉患病率分别为64%和67%。颅内动脉粥样硬化中AC与女性患者的低BMD相关。颅内动脉粥样硬化中PC的女性血磷水平显著升高,而T值显著低于颅内动脉粥样硬化中无PC的女性,高脂血症和低BMD在PC颅内动脉粥样硬化女性中更为常见,低BMD与PC中的颅内动脉粥样硬化显著相关。结论低BMD与女性亚临床颅内PC和AC动脉粥样硬化有关。
文摘OBJECTIVE: To evaluate the value of perfusion MR imaging and angiographic evidence of collateral circulation in symptomatic patients with ischemic cerebrovascular diseases (ICVD). METHODS: Cerebral angiography and perfusion MR were performed in 16 patients with symptoms of ICVD. Qualitative perfusion maps were calculated for regional cerebral blood volume (rCBV) and mean transit time (MTT). RESULTS: A total of 27 lesions were seen on the perfusion MR maps (6 infarcts and 21 ischemic lesions) and most of them (26/27) showed a prolonged MTT. MTT is sensitive to the presence of ischemic lesions, but not sufficient in distinguishing infarct from ischemia. All of the infarcts showed a decreased rCBV, while most of the ischemic lesions showed a normal or increased rCBV. When collateral circulation was identified on angiography, most ischemic lesions were not infarcts and had a normal or increased rCBV. The absence of angiographically identifiable cerebral collaterals may not always result in an infarct; 50% had decreased rCBV. Despite the absence of angiographic collaterals, the other half had normal or increased rCBV. CONCLUSION: Cerebral angiographic evidence of collateral circulation is important in identifying a favorable outcome in patients with ICVD. However, a lesion with a normal or increased rCBV suggests a sufficient collateral circulation even without angiographic collaterals. Perfusion images may be a potentially useful adjunctive tool in the prediction of the outcome of ICVD, particularly where no apparent collateral macrocirculation is seen on CA.
