While studying the neural precursor cell intermediatefilament protein known as nestin in the developing mousebrain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on emb...While studying the neural precursor cell intermediatefilament protein known as nestin in the developing mousebrain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonicday 10 and continued to accumulate until postnatal day 1.Here we report evidence that this protein is a brain-specificvariant form of or-tubulin and discuss its implications.展开更多
Patients with brain tumors,specifically,malignant forms such as glioblastoma,medulloblastoma and ependymoma,exhibit dismal survival rates despite advances in treatment strategies.Chemotherapeutics,the primary adjuvant...Patients with brain tumors,specifically,malignant forms such as glioblastoma,medulloblastoma and ependymoma,exhibit dismal survival rates despite advances in treatment strategies.Chemotherapeutics,the primary adjuvant treatment for human brain tumors following surgery,commonly lack efficacy due to either intrinsic or acquired drug resistance.New treatments targeting epigenetic factors are being explored.Post-translational histone modification provides a critical regulatory platform for processes such as chromosome condensation and segregation,apoptosis,gene transcription,and DNA replication and repair.This work reviews how aberrant histone modifications and alterations in histone-modifying enzymes can drive the acquisition of drug resistance in brain tumors.Elucidating these mechanisms should lead to new treatments for overcoming drug resistance.展开更多
文摘While studying the neural precursor cell intermediatefilament protein known as nestin in the developing mousebrain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonicday 10 and continued to accumulate until postnatal day 1.Here we report evidence that this protein is a brain-specificvariant form of or-tubulin and discuss its implications.
基金Supported by the Rory David Deutsch Foundationthe Surgical Neuro-oncology Research Fund of Ann&Robert H Lurie Children’s Hospital(A&RLCH) of Chicagothe Dr.Ralph and Marian C.Falk Medical Research Trust
文摘Patients with brain tumors,specifically,malignant forms such as glioblastoma,medulloblastoma and ependymoma,exhibit dismal survival rates despite advances in treatment strategies.Chemotherapeutics,the primary adjuvant treatment for human brain tumors following surgery,commonly lack efficacy due to either intrinsic or acquired drug resistance.New treatments targeting epigenetic factors are being explored.Post-translational histone modification provides a critical regulatory platform for processes such as chromosome condensation and segregation,apoptosis,gene transcription,and DNA replication and repair.This work reviews how aberrant histone modifications and alterations in histone-modifying enzymes can drive the acquisition of drug resistance in brain tumors.Elucidating these mechanisms should lead to new treatments for overcoming drug resistance.
