目的:研究人在主动进行肢体运动时脑电(electroencephalogram,EEG)和肢体表面肌电(surface electromyogram,sEMG)信号特征,并与其被动受迫产生相同肢体动作模式时EEG和sEMG信号特征做比较,探讨两者在激活大脑运动皮层神经和产生外周神经...目的:研究人在主动进行肢体运动时脑电(electroencephalogram,EEG)和肢体表面肌电(surface electromyogram,sEMG)信号特征,并与其被动受迫产生相同肢体动作模式时EEG和sEMG信号特征做比较,探讨两者在激活大脑运动皮层神经和产生外周神经-肌肉活动时的不同作用特点与效应,对于了解运动传导通路的功能状态有重要的临床价值,也可为研究开发脑卒中康复治疗新技术提供科学依据。方法:本文主要设计了自主和被动屈腕动作两种实验范式并建立了一套完整的软、硬件系统(LabVIEW软件,DAQ采集卡和视觉反馈系统)进行试验。招募9名被试者(4男,5女)进行了主动和被动屈腕实验,同步采集了被试者EEG和sEMG数据。结果:被动与主动屈腕动作情况下EEG时频变化和平均EMG信号包络幅度的变化及其信号功率谱变化特征趋势大致类似;被动与主动肢体动作事件一样会诱发事件相关去同步(event related de-synchronization,ERD)现象,即证明被动动作下大脑皮层运动区与外周神经系统均能被相应激活,且能够产生联系;被动与主动屈腕时脑-肌电信号频域相干性相似,且被动情况下屈肌EMG与C3脑区EEG信号的相干性幅值比自主动作时增强。这可能是由于被迫动作时会诱发想象动作,从而能增强相应脑区神经元被激发程度。结论:本文结果可支持重复被动肢体运动康复训练的临床实践,并为相关研究提供科学依据。展开更多
In the present paper, effects of electroacupuncture (EA) of 3 points of the Heart Meridian and other 3 points of the Lung Meridian on changes of electrocardiogram (ECG), small intestinal electrogram (SIG) and electroe...In the present paper, effects of electroacupuncture (EA) of 3 points of the Heart Meridian and other 3 points of the Lung Meridian on changes of electrocardiogram (ECG), small intestinal electrogram (SIG) and electroencephalogram (EEG) in intravenous drip of pituitrin induced myocardial ischemia rabbits. The three points of the Heart Meridian are "Shenmen" (HT 7), "Lingdao" (HT 4) and one point between HT 7 and HT 4, the 3 points of the Lung Meridian are "Taiyuan"(LU 9), Lieque (LU 7) and one point between LU 9 and LU 7. These points are punctured with filiform needles and stimulated electrically by setting the parameters being frequency of 2.5 Hz, dense sparse waves and duration of 10 min. Results display that the regulative effect of EA of the Heart Meridian is superior to that of EA of the Lung Meridian on the three indexes, showing a closer correlation between the whole Heart Meridian and activities of ECG, SIG and EEG.展开更多
Objective. To study the features and mechanism of the cerebral evoked potentials by repetitive stimulation of calf muscle in Duchenne muscular dystrophy (DMD) patients with obvious muscular dystrophy and psuedohypertr...Objective. To study the features and mechanism of the cerebral evoked potentials by repetitive stimulation of calf muscle in Duchenne muscular dystrophy (DMD) patients with obvious muscular dystrophy and psuedohypertrophy. Methods. Cerebral evoked potentials by stimulation of calf muscles and somatosensory evoked potentials (SEPs) by the stimulation of posterior tibial nerves at ankle were measured in 10 patients with DMD and 10 normal controls matched with gender and age. The intensity of the magnetic stimulation was at 30% of maximal output (2.1 Tesla, MagPro magnetic stimulator, Dantec) and the frequency was 1 Hz. The low intensity of magnetic stimulation was just sufficient to produce a contraction of the muscle belly underneath the coil. Recording electrode was placed at 2 cm posterior to the Cz, reference to Fpz. The latencies of N33, P38, N48 and P55 and amplitude (P38- N48) were recorded. SEPs were recorded by routine methods. Results. In normal subjects, the amplitudes of cerebral evoked potentials by magnetic stimulation of calf muscle was 40% lower than that by electrical stimulation of the posterior tibial nerves at ankle. The latency of P38 was 2.9± 2.1 ms longer compared with electrical stimulation of the posterior tibial nerves at ankle. In 6 patients, P38 latency from magnetic stimulation was remarkably prolonged (P< 0.01), and in 4 patients, there was no remarkable response. SEPs evoked by electrical stimulation were normal in all of the patients. Conclusion. DMD is an available model for the study of mechanism of cerebral evoked potentials by magnetic stimulating muscle. We can conclude that the responses from magnetic stimulation were produced by muscle input. The abnormal responses in patients may relate to decreased input of muscle by stimulating dystrophic and psedohypertrophic muscle.展开更多
文摘目的:研究人在主动进行肢体运动时脑电(electroencephalogram,EEG)和肢体表面肌电(surface electromyogram,sEMG)信号特征,并与其被动受迫产生相同肢体动作模式时EEG和sEMG信号特征做比较,探讨两者在激活大脑运动皮层神经和产生外周神经-肌肉活动时的不同作用特点与效应,对于了解运动传导通路的功能状态有重要的临床价值,也可为研究开发脑卒中康复治疗新技术提供科学依据。方法:本文主要设计了自主和被动屈腕动作两种实验范式并建立了一套完整的软、硬件系统(LabVIEW软件,DAQ采集卡和视觉反馈系统)进行试验。招募9名被试者(4男,5女)进行了主动和被动屈腕实验,同步采集了被试者EEG和sEMG数据。结果:被动与主动屈腕动作情况下EEG时频变化和平均EMG信号包络幅度的变化及其信号功率谱变化特征趋势大致类似;被动与主动肢体动作事件一样会诱发事件相关去同步(event related de-synchronization,ERD)现象,即证明被动动作下大脑皮层运动区与外周神经系统均能被相应激活,且能够产生联系;被动与主动屈腕时脑-肌电信号频域相干性相似,且被动情况下屈肌EMG与C3脑区EEG信号的相干性幅值比自主动作时增强。这可能是由于被迫动作时会诱发想象动作,从而能增强相应脑区神经元被激发程度。结论:本文结果可支持重复被动肢体运动康复训练的临床实践,并为相关研究提供科学依据。
文摘In the present paper, effects of electroacupuncture (EA) of 3 points of the Heart Meridian and other 3 points of the Lung Meridian on changes of electrocardiogram (ECG), small intestinal electrogram (SIG) and electroencephalogram (EEG) in intravenous drip of pituitrin induced myocardial ischemia rabbits. The three points of the Heart Meridian are "Shenmen" (HT 7), "Lingdao" (HT 4) and one point between HT 7 and HT 4, the 3 points of the Lung Meridian are "Taiyuan"(LU 9), Lieque (LU 7) and one point between LU 9 and LU 7. These points are punctured with filiform needles and stimulated electrically by setting the parameters being frequency of 2.5 Hz, dense sparse waves and duration of 10 min. Results display that the regulative effect of EA of the Heart Meridian is superior to that of EA of the Lung Meridian on the three indexes, showing a closer correlation between the whole Heart Meridian and activities of ECG, SIG and EEG.
文摘Objective. To study the features and mechanism of the cerebral evoked potentials by repetitive stimulation of calf muscle in Duchenne muscular dystrophy (DMD) patients with obvious muscular dystrophy and psuedohypertrophy. Methods. Cerebral evoked potentials by stimulation of calf muscles and somatosensory evoked potentials (SEPs) by the stimulation of posterior tibial nerves at ankle were measured in 10 patients with DMD and 10 normal controls matched with gender and age. The intensity of the magnetic stimulation was at 30% of maximal output (2.1 Tesla, MagPro magnetic stimulator, Dantec) and the frequency was 1 Hz. The low intensity of magnetic stimulation was just sufficient to produce a contraction of the muscle belly underneath the coil. Recording electrode was placed at 2 cm posterior to the Cz, reference to Fpz. The latencies of N33, P38, N48 and P55 and amplitude (P38- N48) were recorded. SEPs were recorded by routine methods. Results. In normal subjects, the amplitudes of cerebral evoked potentials by magnetic stimulation of calf muscle was 40% lower than that by electrical stimulation of the posterior tibial nerves at ankle. The latency of P38 was 2.9± 2.1 ms longer compared with electrical stimulation of the posterior tibial nerves at ankle. In 6 patients, P38 latency from magnetic stimulation was remarkably prolonged (P< 0.01), and in 4 patients, there was no remarkable response. SEPs evoked by electrical stimulation were normal in all of the patients. Conclusion. DMD is an available model for the study of mechanism of cerebral evoked potentials by magnetic stimulating muscle. We can conclude that the responses from magnetic stimulation were produced by muscle input. The abnormal responses in patients may relate to decreased input of muscle by stimulating dystrophic and psedohypertrophic muscle.