To evaluate the biological safety of manufactured heterologous deproteinized bone and to provide an experimental basis for clinical applications. Methods ： Deproteinized bone （ 10 mm） and leaching liquor were made...To evaluate the biological safety of manufactured heterologous deproteinized bone and to provide an experimental basis for clinical applications. Methods ： Deproteinized bone （ 10 mm） and leaching liquor were made from pig ribs with a series of physical and chemical methods, then were evaluated through acute and subacute toxicity test, hemolysis test, pyrogen test, intracutaneous test, intramuscular implantation test and cytotoxity test. Results ： No obvious toxicity, hemolysis, pyrogenic characteristics, skin irritation, inflammatory reaction after intramusclar implantation and cytotoxity were observed. Conclusions： The heterologous deproteinized bone has good biological safety and meets all the demands of scaffold material for tissue engineering.展开更多
Introduction:Rectal prolapse is a condition that occurs infrequently in men and there is little literature guiding treatment in this population.The purpose of this study was to evaluate the surgical approach and outco...Introduction:Rectal prolapse is a condition that occurs infrequently in men and there is little literature guiding treatment in this population.The purpose of this study was to evaluate the surgical approach and outcomes of rectal-prolapse repair in men.Methods:A retrospective multicenter review was conducted of consecutive men who underwent rectal-prolapse repair between 2004 and 2014.Surgical approaches and outcomes,including erectile function and fecal continence,were evaluated.Results:During the study period,58 men underwent rectal-prolapse repair and the mean age of repair was 52.7624.1 years.The mean follow-up was 13.2 months(range,0.5–117 months).The majority of patients underwent endoscopic evaluation(78%),but few patients underwent anal manometry(16%),defecography(9%)or ultrasound(3%).Ten patients(17%)underwent biofeedback/pelvic-floor physical therapy prior to repair.Nineteen patients(33%)underwent a perineal approach(most were perineal proctosigmoidectomy).Thirty-nine patients(67%)underwent repair using an abdominal approach(all were suture rectopexy)and,of these,77%were completed using a minimally invasive technique.The overall complication rate was 26%including urinary retention(16%),which was more common in patients undergoing the perineal approach(32%vs.8%,P=0.028),urinary-tract infection(7%)and wound infection(3%).The overall recurrence rate was 9%,with no difference between abdominal and perineal approaches.Information on sexual function was missing in the majority of patients both before and after surgery(76%and 78%,respectively).Conclusion:Rectal-prolapse repair in men is safe and has a low recurrence rate;however,sexual function was poorly recorded across all institutions.Further studies are needed to evaluate to best approach to and functional outcomes of rectal-prolapse repair in men.展开更多
文摘To evaluate the biological safety of manufactured heterologous deproteinized bone and to provide an experimental basis for clinical applications. Methods ： Deproteinized bone （ 10 mm） and leaching liquor were made from pig ribs with a series of physical and chemical methods, then were evaluated through acute and subacute toxicity test, hemolysis test, pyrogen test, intracutaneous test, intramuscular implantation test and cytotoxity test. Results ： No obvious toxicity, hemolysis, pyrogenic characteristics, skin irritation, inflammatory reaction after intramusclar implantation and cytotoxity were observed. Conclusions： The heterologous deproteinized bone has good biological safety and meets all the demands of scaffold material for tissue engineering.
文摘Introduction:Rectal prolapse is a condition that occurs infrequently in men and there is little literature guiding treatment in this population.The purpose of this study was to evaluate the surgical approach and outcomes of rectal-prolapse repair in men.Methods:A retrospective multicenter review was conducted of consecutive men who underwent rectal-prolapse repair between 2004 and 2014.Surgical approaches and outcomes,including erectile function and fecal continence,were evaluated.Results:During the study period,58 men underwent rectal-prolapse repair and the mean age of repair was 52.7624.1 years.The mean follow-up was 13.2 months(range,0.5–117 months).The majority of patients underwent endoscopic evaluation(78%),but few patients underwent anal manometry(16%),defecography(9%)or ultrasound(3%).Ten patients(17%)underwent biofeedback/pelvic-floor physical therapy prior to repair.Nineteen patients(33%)underwent a perineal approach(most were perineal proctosigmoidectomy).Thirty-nine patients(67%)underwent repair using an abdominal approach(all were suture rectopexy)and,of these,77%were completed using a minimally invasive technique.The overall complication rate was 26%including urinary retention(16%),which was more common in patients undergoing the perineal approach(32%vs.8%,P=0.028),urinary-tract infection(7%)and wound infection(3%).The overall recurrence rate was 9%,with no difference between abdominal and perineal approaches.Information on sexual function was missing in the majority of patients both before and after surgery(76%and 78%,respectively).Conclusion:Rectal-prolapse repair in men is safe and has a low recurrence rate;however,sexual function was poorly recorded across all institutions.Further studies are needed to evaluate to best approach to and functional outcomes of rectal-prolapse repair in men.
