AIM＂ TO evaluate the impact of alcohol dehydrogenase 2 （ADH2） and aldehyde dehydrogenase 2 （ALDH2） polymorphisms on esophageal cancer risk. METHODS;One hundred and ninety-one esophageal cancer patients and 198 he...AIM＂ TO evaluate the impact of alcohol dehydrogenase 2 （ADH2） and aldehyde dehydrogenase 2 （ALDH2） polymorphisms on esophageal cancer risk. METHODS;One hundred and ninety-one esophageal cancer patients and 198 healthy controls from Yanting County were enrolled in this study. ADH2 and ALDH2 genotypes were examined by polymerase-chain-reaction with the confronting-two-pair-primer （PCR-CTPP） method. Unconditional logistic regression was used to calculate the odds ratios （OR） and 95% confidence interval （95% CI）. RESULTS; Both ADH2＊1 allele and ALDH2＊1/＊2 allele showed an increased risk of developing esophageal cancer. The adjusted OR （95% CI） for ADH2＊1 allele compared with ADH2＊2/＊2 was 1.65 （95% CI = 1.02-2.68） and 1.67 （95% CI = 1.02-2.72） for ALDH2＊1/＊2 compared with ALDH2＊1/＊1. A significant interaction between ALDH2 and drinking was detected regarding esophageal cancer risk, the OR was 1.83 （95% CI = 1.13-2.95）. Furthermore, when compared with ADH2＊2/＊2 and ALDH2＊1/＊1 carriers, ADH2＊1 and ALDH2＊2 carriers showed an elevated risk of developing esophageal cancer among non-alcohol drinkers展开更多
Objective： To analyze the results and introduce the experiences of transhiatal esophagectomy in combined with different synthetic therapy. Methods： Seventy-one patients with esophageal carcinoma, median age was 62, ...Objective： To analyze the results and introduce the experiences of transhiatal esophagectomy in combined with different synthetic therapy. Methods： Seventy-one patients with esophageal carcinoma, median age was 62, 40 of stage Ⅰ, 26 of Ⅱa, 4 of stage Ⅱb, 1 of stage Ⅳ, were treated with transhiatal esophagectomy. 9 and 17 patients were treated with preoperative radiotherapy （4000 cGy） and postoperative adjuvant radiotherapy （6000 cGy） respectively; 5 patients were treated with preoperative chemotherapy. Results： The postoperative 1, 3 and 5 years survival rates were 100%, 91.43%, and 86.21% for stage Ⅰ; 92%, 83.33%, and 57.14% for stage Ⅱa; 75%, 50%, and 50% for stage Ⅱb; 100%, 0, and 0 for stag Ⅳ and 95.71%, 86.89%, and 71.70% as a whole, respectively. The incidence of complications was 12.68%. Conclusion： Transhiatal esophagectomy combined with chemotherapy or radiotherapy may be beneficial to patients with esophageal carcinoma at stage Ⅱa or earlier who can＇t tolerate or need not be treated by transthoracic esophagectomy.展开更多
The treatments of shoulder joint subluxation following apoplexy with acupuncture, tuina, acupoint injection, and comprehensive methods in recent 10 years were reviewed. By comparing and analyzing the clinical effects ...The treatments of shoulder joint subluxation following apoplexy with acupuncture, tuina, acupoint injection, and comprehensive methods in recent 10 years were reviewed. By comparing and analyzing the clinical effects of different methods, acupuncture combing with rehabilitation therapy is considered as a satisfactory one in treating subluxation following apoplexy.展开更多
基金Supported partly by Sichuan University Youth Scientific Research Fund (2003) and partly by research fund from Sasakawa Classmate Association (065)
文摘AIM＂ TO evaluate the impact of alcohol dehydrogenase 2 （ADH2） and aldehyde dehydrogenase 2 （ALDH2） polymorphisms on esophageal cancer risk. METHODS;One hundred and ninety-one esophageal cancer patients and 198 healthy controls from Yanting County were enrolled in this study. ADH2 and ALDH2 genotypes were examined by polymerase-chain-reaction with the confronting-two-pair-primer （PCR-CTPP） method. Unconditional logistic regression was used to calculate the odds ratios （OR） and 95% confidence interval （95% CI）. RESULTS; Both ADH2＊1 allele and ALDH2＊1/＊2 allele showed an increased risk of developing esophageal cancer. The adjusted OR （95% CI） for ADH2＊1 allele compared with ADH2＊2/＊2 was 1.65 （95% CI = 1.02-2.68） and 1.67 （95% CI = 1.02-2.72） for ALDH2＊1/＊2 compared with ALDH2＊1/＊1. A significant interaction between ALDH2 and drinking was detected regarding esophageal cancer risk, the OR was 1.83 （95% CI = 1.13-2.95）. Furthermore, when compared with ADH2＊2/＊2 and ALDH2＊1/＊1 carriers, ADH2＊1 and ALDH2＊2 carriers showed an elevated risk of developing esophageal cancer among non-alcohol drinkers
文摘Objective： To analyze the results and introduce the experiences of transhiatal esophagectomy in combined with different synthetic therapy. Methods： Seventy-one patients with esophageal carcinoma, median age was 62, 40 of stage Ⅰ, 26 of Ⅱa, 4 of stage Ⅱb, 1 of stage Ⅳ, were treated with transhiatal esophagectomy. 9 and 17 patients were treated with preoperative radiotherapy （4000 cGy） and postoperative adjuvant radiotherapy （6000 cGy） respectively; 5 patients were treated with preoperative chemotherapy. Results： The postoperative 1, 3 and 5 years survival rates were 100%, 91.43%, and 86.21% for stage Ⅰ; 92%, 83.33%, and 57.14% for stage Ⅱa; 75%, 50%, and 50% for stage Ⅱb; 100%, 0, and 0 for stag Ⅳ and 95.71%, 86.89%, and 71.70% as a whole, respectively. The incidence of complications was 12.68%. Conclusion： Transhiatal esophagectomy combined with chemotherapy or radiotherapy may be beneficial to patients with esophageal carcinoma at stage Ⅱa or earlier who can＇t tolerate or need not be treated by transthoracic esophagectomy.
文摘The treatments of shoulder joint subluxation following apoplexy with acupuncture, tuina, acupoint injection, and comprehensive methods in recent 10 years were reviewed. By comparing and analyzing the clinical effects of different methods, acupuncture combing with rehabilitation therapy is considered as a satisfactory one in treating subluxation following apoplexy.
