Background: Campylobacter jejuni enteritis is the most common antecedent infection in Guillain Barré syndrome (GBS). C. jejuni related GBS is usually acute motor axonal neuropathy (AMAN), but previous reports des...Background: Campylobacter jejuni enteritis is the most common antecedent infection in Guillain Barré syndrome (GBS). C. jejuni related GBS is usually acute motor axonal neuropathy (AMAN), but previous reports described many cases of the demyelinating subtype of GBS (acute inflammatory demyelinating polyneuropathy ) after C. jejuni infection. Objective: To investigate whether C. jejuni infection elicits AIDP. Methods: In 159 consecutive patients with GBS, antibodies against C. jejuni were measured using ELISA. Antecedent C. jejuni infection was determined by the strict criteria of positive C. jejuni serology and a history of a diarrheal illness within the previous 3 weeks. Electrodiagnostic studies were performed weekly for the first 4 weeks, and sequential findings were analyzed. Results: There was evidence of recent C. jejuni infection in 22 (14% ) patients. By electrodiagnostic criteria, these patients were classified with AMAN (n = 16; 73% ) or AIDP (n = 5; 23% ) or as unclassified (n = 1) in the first studies. The five C. jejuni positive patients with the AIDP pattern showed prolongedmotor distal latencies in two or more nerves and had their rapid normalization within 2 weeks, eventually all showing the AMAN pattern. In contrast, patients with cytomegalovirus or Epstein Barr virus related AIDP (n = 13) showed progressive increases in distal latencies in the 8 weeks after onset. Conclusion: Patients with C. jejuni related Guillain Barré syndrome can show transient slowing of nerve conduction, mimicking demyelination, but C. jejuni infection does not appear to elicit acute inflammatory demyelinating polyneuropathy.展开更多
We reviewed 100 cases with Guillain－ Barré syndrome (GBS) from 1980 to 1999, and found that the features of GBS in electrophysiological classification, age, area, seasonal distributions, and in preceding illness...We reviewed 100 cases with Guillain－ Barré syndrome (GBS) from 1980 to 1999, and found that the features of GBS in electrophysiological classification, age, area, seasonal distributions, and in preceding illness in northwestern China are different in some aspects from those in Europe and North America or in northern China. The demyelinating pattern appeares as a major subtype not only in different age groups, but also in different test times after symptom onset.展开更多
文摘Background: Campylobacter jejuni enteritis is the most common antecedent infection in Guillain Barré syndrome (GBS). C. jejuni related GBS is usually acute motor axonal neuropathy (AMAN), but previous reports described many cases of the demyelinating subtype of GBS (acute inflammatory demyelinating polyneuropathy ) after C. jejuni infection. Objective: To investigate whether C. jejuni infection elicits AIDP. Methods: In 159 consecutive patients with GBS, antibodies against C. jejuni were measured using ELISA. Antecedent C. jejuni infection was determined by the strict criteria of positive C. jejuni serology and a history of a diarrheal illness within the previous 3 weeks. Electrodiagnostic studies were performed weekly for the first 4 weeks, and sequential findings were analyzed. Results: There was evidence of recent C. jejuni infection in 22 (14% ) patients. By electrodiagnostic criteria, these patients were classified with AMAN (n = 16; 73% ) or AIDP (n = 5; 23% ) or as unclassified (n = 1) in the first studies. The five C. jejuni positive patients with the AIDP pattern showed prolongedmotor distal latencies in two or more nerves and had their rapid normalization within 2 weeks, eventually all showing the AMAN pattern. In contrast, patients with cytomegalovirus or Epstein Barr virus related AIDP (n = 13) showed progressive increases in distal latencies in the 8 weeks after onset. Conclusion: Patients with C. jejuni related Guillain Barré syndrome can show transient slowing of nerve conduction, mimicking demyelination, but C. jejuni infection does not appear to elicit acute inflammatory demyelinating polyneuropathy.
文摘We reviewed 100 cases with Guillain－ Barré syndrome (GBS) from 1980 to 1999, and found that the features of GBS in electrophysiological classification, age, area, seasonal distributions, and in preceding illness in northwestern China are different in some aspects from those in Europe and North America or in northern China. The demyelinating pattern appeares as a major subtype not only in different age groups, but also in different test times after symptom onset.
