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中孕期母血清甲胎蛋白和游离β-hCG筛查胎儿腹裂和脐膨出的效率 被引量:8
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作者 陈益明 张闻 +6 位作者 卢莎 梅瑾 王昊 王姗 顾琳媛 张丽丹 褚雪莲 《浙江大学学报(医学版)》 CAS CSCD 北大核心 2017年第3期268-273,共6页
目的:评估中孕期母血清甲胎蛋白(MSAFP)和游离人绒毛膜促性腺激素β亚基(β-hCG)在产前筛查胎儿腹裂和脐膨出中的价值。方法:回顾性分析2007年10月至2016年9月在杭州市五家产前筛查中心自愿接受产前筛查的622 639名孕妇的出生缺陷监测... 目的:评估中孕期母血清甲胎蛋白(MSAFP)和游离人绒毛膜促性腺激素β亚基(β-hCG)在产前筛查胎儿腹裂和脐膨出中的价值。方法:回顾性分析2007年10月至2016年9月在杭州市五家产前筛查中心自愿接受产前筛查的622 639名孕妇的出生缺陷监测资料及产前筛查随访结果。根据有无胎儿先天性腹壁缺损(腹裂、脐膨出)将研究对象分为病例组和健康对照组。病例组是指经超声诊断并通过终止妊娠确诊为腹裂和脐膨出胎儿的孕妇共60例,包括腹裂组30例、脐膨出组30例;健康对照组为随机抽取同时期胎儿发育正常的孕妇116名。采用时间分辨荧光免疫法检测两病例和健康对照组MSAFP、游离β-hCG水平。用受试者工作特征(ROC)曲线对MSAFP和游离β-hCG的筛查效能进行评价。结果:腹裂组孕妇MSAFP水平为4.41(0.88~11.69)MOM,脐膨出组为2.31(0.72~23.20)MOM,均高于健康对照组的0.98(0.41~2.26)MOM,差异均有统计学意义(均P<0.01)。腹裂组血清游离β-hCG水平为1.25(0.35~19.94)MOM,高于健康对照组的0.86(0.17~6.11)MOM,差异有统计学意义(P<0.05);脐膨出组游离β-hCG水平为1.03(0.21~8.95)MOM,与健康对照组比较差异无统计学意义(P>0.05)。MSAFP筛查腹裂和脐膨出胎儿的AUC分别为0.897(95%CI:0.822~0.972)和0.852(95%CI:0.762~0.942)(均P<0.01)。MSAFP筛查先天腹壁缺损(腹裂、脐膨出)的最佳临界值为1.655 MOM,此时的敏感度为68.30%,特异度为99.60%,约登指数为0.649。结论:中孕期MSAFP筛查先天腹壁缺损具有较高的敏感度和特异度,是筛查先天腹壁缺损的一个较好的标志物。 展开更多
关键词 绒毛膜促性腺激素 β-亚单位 人/血液 甲胎蛋白类/血液 腹裂/病 因学疝 /病因学 壁/畸形 孕妇 妊娠中期 产前诊断 例对照研究
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Bile peritonitis due to intra-hepatic bile duct rupture 被引量:1
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作者 R Lochan BV Joypaul 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第42期6728-6729,共2页
Generalized biliary peritonitis is a serious intra-abdominal emergency. Most of them occur due to duodenal ulcer perforation and rapidly evolve into bacterial peritonitis due to contamination by gut organisms and food... Generalized biliary peritonitis is a serious intra-abdominal emergency. Most of them occur due to duodenal ulcer perforation and rapidly evolve into bacterial peritonitis due to contamination by gut organisms and food. In this situation, recognition of the pathology and its treatment is straightforward and is usually associated with a good outcome. There are a few unusual causes of biliary peritonitis, of which rupture of the biliary tree is one.We describe a rare case of biliary peritonitis due to rupture of an intra-hepatic biliary radical. Unusual causes of peritonitis do interrupt our daily routine emergency surgical experience. Rapid recognition of the presence of peritonitis, adequate resuscitation, recognition of operative findings, establishment of biliary anatomy, and performance of a meticulous surgical procedure resulted in a good outcome. 展开更多
关键词 Biliary peritonitis Intra-hepatic biliary radicle RUPTURE
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Spontaneous rupture of a hepatic hydatid cyst into the peritoneum causing only mild abdominal pain:A case report 被引量:2
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作者 Kemal Karakaya 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第5期806-808,共3页
Hydatid disease is an endemic disease in certain areas of the world. It is located mostly in the liver. Spontaneous rupture of the hydatid cyst into the peritoneum is a rare condition, which is accompanied by serious ... Hydatid disease is an endemic disease in certain areas of the world. It is located mostly in the liver. Spontaneous rupture of the hydatid cyst into the peritoneum is a rare condition, which is accompanied by serious morbidity and mortality generally. We present herein a case with a spontaneous rupture of a hepatic hidatid disease into the peritoneum without any serious symptoms. A 15-year- old boy was admitted to the emergency room with a mild abdominal pain lasting for a day. Physical examination revealed only mild abdominal tenderness. There was no history of trauma or complaints related to hydatid diseases. Ultrasonography showed a large amount of free fluid and a cystic lesion with irregular borders in the liver. He was operated on. Postoperative albendazol therapy was given for 2 mo. No recurrence or secondary hydatidosis was seen on CT investigation in the 3^th, 6^th and 12^th mo following surgery. 展开更多
关键词 Hydatid disease Spontaneous rupture LIVER
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Complications of collagenous colitis
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作者 Hugh James Freeman 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第11期1643-1645,共3页
Microscopic forms of colitis have been described, including collagenous colitis. This disorder generally has an apparently benign clinical course. However, a number of gastric and intestinal complications, possibly co... Microscopic forms of colitis have been described, including collagenous colitis. This disorder generally has an apparently benign clinical course. However, a number of gastric and intestinal complications, possibly coincidental, may develop with collagenous colitis. Distinctive inflammatory disorders of the gastric mucosa have been described, including lymphocytic gastritis and collagenous gastritis. Celiac disease and collagenous sprue (or collagenous enteritis) may occur. Colonic ulceration has been associated with use of nonsteroidal anti-inflammatory drugs, while other forms of inflammatory bowel disease, including ulcerative colitis and Crohn's disease, may evolve from coUagenous colitis. Submucosal "dissection", colonic fractures or mucosal tears and perforation from air insufflation during colonoscopy may occur and has been hypothesized to be due to compromise of the colonic wall from submucosal collagen deposition. Similar changes may result from increased intraluminal pressure during barium enema contrast studies. Finally, malignant disorders have also been reported, including carcinoma and lymphoproliferative disease. 展开更多
关键词 Colonic fractures Colonic perforation Celiac disease Collagenous gastritis Collagenous sprue Cat scratch colon Colon cancer Microscopic colitis
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Spontaneous rupture of the giant gastric stromal tumor(> 35 cm) as a rare cause of acute abdomen: a case report 被引量:1
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作者 Libo Feng Dong Xia +2 位作者 Qing Liu Yi Liu Liang Xu 《The Chinese-German Journal of Clinical Oncology》 CAS 2014年第4期194-196,共3页
A case of spontaneous rupture of giant gastrointestinal stromal tumor(GIST) of stomach causing acute abdomen is described below. A male patient with abdominal mass presented with symptoms and signs of acute abdomen af... A case of spontaneous rupture of giant gastrointestinal stromal tumor(GIST) of stomach causing acute abdomen is described below. A male patient with abdominal mass presented with symptoms and signs of acute abdomen after admitting for 1 day. After preoperative management and evaluation, an exploratory laparotomy was performed, where rupture of a huge tumor in the stomach was found. A subtotal gastrectomy including the mass was performed and the final immunohistochemical examination verified that the neoplasm was a high risk GIST. The postoperative period was uneventful and the patient received treatment with imatinib mesylate, and regular follow-up without recurrence. 展开更多
关键词 gastric stromal tumor RUPTURE acute abdomen SURGERY
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