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基于支持向量机集成方法的膀胱癌预后研究
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作者 杨帆 杨大利 朱熹 《北京信息科技大学学报(自然科学版)》 2017年第1期24-31,共8页
将支持向量机方法应用于膀胱癌预后研究,提出一种基于差异性的BoostingSVM模型集成方法。膀胱癌患者数据集呈现小样本、类别不平衡特性。故通过重采样得到局部类别平衡的子训练集,以获得泛化性良好的支持向量机基分类器。同时提出一种... 将支持向量机方法应用于膀胱癌预后研究,提出一种基于差异性的BoostingSVM模型集成方法。膀胱癌患者数据集呈现小样本、类别不平衡特性。故通过重采样得到局部类别平衡的子训练集,以获得泛化性良好的支持向量机基分类器。同时提出一种基于差异性度量的模型调优方法,增大基分类器间的差异性,克服样本量不足的问题,提高模型整体的泛化性。实验表明,改进方法相比于传统支持向量机方法相对错误率下降17.76%,多数类和少数类平均召回率的标准差相对下降84.36%。 展开更多
关键词 膀胱癌预后 支持向量机 集成学习 基分类器 差异性
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成纤维细胞生长因子受体3的表达预测膀胱癌预后 被引量:1
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作者 黄玉清 张良 +1 位作者 周海滨 李丹丹 《吉林医学》 CAS 2022年第6期1479-1480,共2页
目的:探讨研究成纤维细胞生长因子受体3(FGFR3)的表达预测膀胱癌预后的临床意义。方法:选择2017年4月~2021年4月膀胱癌患者80例为观察对象,分析FGFR3基因热点突变外显因子(7、10、15)和FGFR3蛋白表达在膀胱癌预后中的预测价值。结果:FG... 目的:探讨研究成纤维细胞生长因子受体3(FGFR3)的表达预测膀胱癌预后的临床意义。方法:选择2017年4月~2021年4月膀胱癌患者80例为观察对象,分析FGFR3基因热点突变外显因子(7、10、15)和FGFR3蛋白表达在膀胱癌预后中的预测价值。结果:FGFR3基因突变率、蛋白表达率分别为18.75%、27.50%;FGFR3基因突变与年龄、吸烟史、病理分期、肿瘤大小、复发情况等参数指标存在相关性(P<0.05);FGFR3基因突变和蛋白表达一致性为33.33%,但二者没有关联(P>0.05);FGFR3基因突变和蛋白表达与患者总生存期(OS)无联系(P>0.05),FGFR3蛋白表达对无瘤生存期(DFS)不会造成影响(P>0.05),但FGFR3基因突变型膀胱癌的DFS显著低于野生型(P<0.05)。结论:FGFR3用于膀胱癌预后评估中有一定应用价值,可根据FGFR3基因变化来评估膀胱癌复发风险,但患者DFS短,需加强FGFR3基因突变监测来采取对症处理。 展开更多
关键词 成纤维细胞生长因子受体3 膀胱癌预后 预测价值
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Expression and Significance of PTEN in Bladder Transitional Cell Carcinoma 被引量:1
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作者 张建华 杨为民 周四维 《The Chinese-German Journal of Clinical Oncology》 CAS 2005年第4期218-220,共3页
Objective: To explore the expression of anti-oncogene PTEN in bladder transitional cell carcinoma and its clinical significance. Methods: Using immunohistochemical S-P methods, the expression of PTEN gene was detect... Objective: To explore the expression of anti-oncogene PTEN in bladder transitional cell carcinoma and its clinical significance. Methods: Using immunohistochemical S-P methods, the expression of PTEN gene was detected in 62 specimens of bladder cancer and 18 specimens of normal bladder tissue. Results: In the 62 bladder cancers, the positive rate of PTEN was 53.2% (33/62). All 18 normal bladder tissues were positive for the PTEN expression. The expression of PTEN was negatively correlated to tumor grades (P〈0.05). Conclusion: The reduced expression of PETN might play an important role in carcinogenesis and progression of bladder cancer. Detection of PTEN might be useful for judgement of tumor development and prognosis. 展开更多
关键词 transitional cell carcinoma PTEN gene IMMUNOHISTOCHEMISTRY
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A clinical analysis and prognostic study of 62 cases with T1G3 urothelial carcinoma of the bladder
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作者 Fengyao Wang Qinchao Yu Yanan Liu 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第4期233-236,共4页
Objective:The aim of our study was to clarify the clinicopathological factors affecting the outcome of T1G3 urothelial carcinoma of the bladder.Methods:We retrospectively reviewed 62 cases of T1G3 bladder cancer treat... Objective:The aim of our study was to clarify the clinicopathological factors affecting the outcome of T1G3 urothelial carcinoma of the bladder.Methods:We retrospectively reviewed 62 cases of T1G3 bladder cancer treated with transuretheral resection of bladder toumor (TURBT) followed by intravesical instillation between 1997 and 2009.Cumulative survival was analyzed by Kaplan-Meier method.Cox regression was used for univariate and multivariate analysis.Log-rank method was used for the significance test.The statistical difference was accepted when the P value was lower than 0.05.Results:Median follow-up period was 40 months (6-140 months).Forty-one cases of intravesical recurrence (66%) were observed during follow-up.Two-and 5-year recurrence-free survival rates were 43.4% and 35.1%.Fourteen cases of progression (23%) were observed during the follow-up period.Two-and 5-year progression-free survival rates were 86.4% and 83.5%,respectively.Significant factors for tumor recurrence and progression were analyzed by Cox regression.Tumor multiplicity (RR=2.250),size (RR=1.039) and history of recurrence (RR=2.162) were significantly correlated with recurrence and tumor multiplicity (RR=3.695) was significantly correlated with progression on multivariate analysis.Conclusion:Tumor multiplicity,size,history of recurrence were correlated with recurrence and tumor multiplicity was significantly correlated with progression.Tumor multiplicity,size and history of recurrence should be taken into account when we make therapy strategies for T1G3 urothelial carcinoma of the bladder. 展开更多
关键词 T1G3 urothelial carcinoma of the bladder PROGNOSIS survival analysis
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Prognostic value of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in bladder carcinoma 被引量:1
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作者 许克新 侯树坤 杜志军 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第5期743-745,155,共3页
OBJECTIVES: To detect the level of matrix metalloproteinase-2 (MMP-2) mRNA and the tissue inhibitor of metalloproteinase-2 (TIMP-2) mRNA in bladder transitional cell carcinoma (BTCC), and to estimate the prognosis for... OBJECTIVES: To detect the level of matrix metalloproteinase-2 (MMP-2) mRNA and the tissue inhibitor of metalloproteinase-2 (TIMP-2) mRNA in bladder transitional cell carcinoma (BTCC), and to estimate the prognosis for bladder tumor based on the quality and quantity of MMP-2 and TIMP-2 mRNA. METHODS: Thirty-five samples of human BTCC and 15 normal fresh bladder tissues were studied by RT-PCR analysis followed by computer-assisted image analysis. RESULTS: The level of the MMP-2 mRNA in BTCC was significantly increased compared with that in normal bladder epithelium. The positive rates of MMP-2 and TIMP-2 mRNA were 71.4% and 65.7% in BTCC, and 66.7% and 60.0% in the normal bladder wall. The expression intensity of the MMP-2 mRNA by image analysis tended to increase with tumor grading and staging, which showed statistical significance. Similarly, the MMP-2 to TIMP-2 ratio also showed statistically significant difference between normal bladder tissue and bladder carcinoma (P 展开更多
关键词 ADULT Aged Aged 80 and over BLADDER Bladder Neoplasms FEMALE Gelatinase A Gene Expression Regulation Neoplastic Humans Male Middle Aged Neoplasm Staging Predictive Value of Tests Prognosis RNA Messenger Research Support Non-U.S. Gov't Tissue Inhibitor of Metalloproteinase-2
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