脾主运化,为气血生化之源,也是膏脂转输的重要保障,血脂亦由水谷精微所化生,并依赖脾的运化功能输布周身。脾失健运、膏脂转输障碍是血脂异常的关键病机。高密度脂蛋白(high density lipoprotein,HDL)在疾病状态之下发生翻译后修饰成为...脾主运化,为气血生化之源,也是膏脂转输的重要保障,血脂亦由水谷精微所化生,并依赖脾的运化功能输布周身。脾失健运、膏脂转输障碍是血脂异常的关键病机。高密度脂蛋白(high density lipoprotein,HDL)在疾病状态之下发生翻译后修饰成为“失功能”HDL (dysfunctional HDL,dys-HDL),影响其参与胆固醇逆向转运、抗炎、抗氧化等作用,导致血脂异常从而诱发动脉粥样硬化(atherosclerosis,AS)的发生发展并产生与其相关的标志物。本文在“脾主运化”的理论指导下,探讨“脾失健运-膏脂转输障碍”与HDL蛋白修饰的关系,将有助于从HDL及其亚类蛋白修饰层面丰富脾主运化理论的科学内涵,为临床“从脾论治”AS性心血管疾病提供新思路和新靶点。展开更多
肥胖是一种发生在脂肪组织中,由于能量代谢失衡而导致患者体重升高,超出标准体重20%的疾病。由于肥胖可以导致高血压、糖尿病、胰岛素抵抗等多种疾病,并且我国肥胖患者的数量仍然有逐年增加的趋势,因此解决肥胖问题已经成为我国的一项...肥胖是一种发生在脂肪组织中,由于能量代谢失衡而导致患者体重升高,超出标准体重20%的疾病。由于肥胖可以导致高血压、糖尿病、胰岛素抵抗等多种疾病,并且我国肥胖患者的数量仍然有逐年增加的趋势,因此解决肥胖问题已经成为我国的一项重要任务。膏脂理论源于《黄帝内经》中对于膏脂的论述,认为肥胖大多由膏脂积聚所导致。治疗方面多采用山楂、红曲、决明子等中药消膏降浊,再结合临床实际情况辨证论治,合理施药。为中医中药治疗肥胖提供新思路。Obesity is a disease that occurs in the adipose tissue and causes the patient’s body weight to rise by more than 20% of the standard body weight due to the imbalance of energy metabolism. Since obesity can lead to hypertension, diabetes, insulin resistance and other diseases, and the number of obese patients in China is still increasing year by year, solving the obesity problem has become an important task in China. The theory of paste fat comes from the discussion on paste fat in Huangdi Neijing, which believes that obesity is mostly caused by the accumulation of paste fat. In terms of treatment, hawthorn, red yeast, Cassia seed and other traditional Chinese medicines are used to reduce turbidity, and then combined with the clinical situation of syndrome differentiation and treatment, reasonable application of medicine. It provides a new idea for the treatment of obesity with traditional Chinese medicine.展开更多
文摘脾主运化,为气血生化之源,也是膏脂转输的重要保障,血脂亦由水谷精微所化生,并依赖脾的运化功能输布周身。脾失健运、膏脂转输障碍是血脂异常的关键病机。高密度脂蛋白(high density lipoprotein,HDL)在疾病状态之下发生翻译后修饰成为“失功能”HDL (dysfunctional HDL,dys-HDL),影响其参与胆固醇逆向转运、抗炎、抗氧化等作用,导致血脂异常从而诱发动脉粥样硬化(atherosclerosis,AS)的发生发展并产生与其相关的标志物。本文在“脾主运化”的理论指导下,探讨“脾失健运-膏脂转输障碍”与HDL蛋白修饰的关系,将有助于从HDL及其亚类蛋白修饰层面丰富脾主运化理论的科学内涵,为临床“从脾论治”AS性心血管疾病提供新思路和新靶点。
文摘肥胖是一种发生在脂肪组织中,由于能量代谢失衡而导致患者体重升高,超出标准体重20%的疾病。由于肥胖可以导致高血压、糖尿病、胰岛素抵抗等多种疾病,并且我国肥胖患者的数量仍然有逐年增加的趋势,因此解决肥胖问题已经成为我国的一项重要任务。膏脂理论源于《黄帝内经》中对于膏脂的论述,认为肥胖大多由膏脂积聚所导致。治疗方面多采用山楂、红曲、决明子等中药消膏降浊,再结合临床实际情况辨证论治,合理施药。为中医中药治疗肥胖提供新思路。Obesity is a disease that occurs in the adipose tissue and causes the patient’s body weight to rise by more than 20% of the standard body weight due to the imbalance of energy metabolism. Since obesity can lead to hypertension, diabetes, insulin resistance and other diseases, and the number of obese patients in China is still increasing year by year, solving the obesity problem has become an important task in China. The theory of paste fat comes from the discussion on paste fat in Huangdi Neijing, which believes that obesity is mostly caused by the accumulation of paste fat. In terms of treatment, hawthorn, red yeast, Cassia seed and other traditional Chinese medicines are used to reduce turbidity, and then combined with the clinical situation of syndrome differentiation and treatment, reasonable application of medicine. It provides a new idea for the treatment of obesity with traditional Chinese medicine.
