青少年跳水运动员膝关节力量训练手段的实验研究

采用等动肌力测试仪对受试者训练前后的膝肌力进行了测试与比较,研究认为:青少年跳水运动员的峰力矩,相当峰力矩,峰力矩屈/伸在试验前后的比较汇总都有显著性变化,得到明显地提高;说明本试验以屈膝状态下半蹲或者跳跃练习使膝关节的肌群力量得到锻炼和提高。

全膝关节置换后关节线变化对髌股关节生物力学的影响

背景:全膝关节置换翻修的主要原因除感染外,聚乙烯衬垫磨损以及假体松动也是最常见的原因,关节线高度对髌股关节生物力学的影响尚无定论。目的:观察全膝关节置换后关节线变化对髌股关节生物力学的影响。方法:建立全膝关节置换后膝关节三维有限元模型,计算膝关节屈曲度在0°,30°,60°和90°时不同关节线高度对股四头肌拉力、骸韧带拉力和髌股关节间作用力变化的影响。结果与结论:1膝关节屈曲0°时,关节线高度在-3-4.5 mm变化对股四头肌拉力、膑腱拉力和髌股关节间作用力没有太大影响。2在膝关节屈曲30°-90°时,关节线高度在3 mm以下对股四头肌拉力、膑腱拉力和髌股关节间作用力影响不大;关节线高度超过3 mm对股四头肌拉力、膑腱拉力和髌股关节间作用力的影响比较明显。3因此建议全膝关节置换术中关节线的高度最好控制在正负3 mm以内。

Potential Targets and Molecular Mechanism of Quercetin Against Knee Osteoarthritis

Objective The objective of this study was to clarify the potential mechanism of quercetin against knee osteoarthritis(KOA)based on network pharmacology and molecular docking.Methods The targets of quercetin were predicted by PubChem and Swiss Target Prediction databases,and the targets of KOA were obtained by DisGeNET,OMIM,and GeneCards databases.Then,the targets of quercetin and KOA were intersected to find the potential targets of quercetin against KOA.The protein–protein interaction network was constructed through the STRING database,and the core targets were screened.Gene ontology(GO)functions enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed using DAVID database.The drug–target–pathway–disease network was constructed by Cytoscape software,and the molecular docking verification was performed by Vina.Results There were 49 potential targets for quercetin against KOA,including 10 core targets.GO functions enrichment analysis showed that the biological process of quercetin against KOA mainly involved the negative regulation of apoptotic process,collagen catabolic process,and extracellular matrix disassembly.KEGG pathway enrichment analysis showed that quercetin against KOA was closely related to PI3K-Akt signaling pathway,Rap 1 signaling pathway,FoxO signaling pathway,Ras signaling pathway,TNF signaling pathway,and ErbB signaling pathway.The results of molecular docking showed that the binding energies between ligand and receptors were less than−5 kcal·mol−1.Conclusions The molecular mechanism of quercetin against KOA involves many targets and pathways,which can regulate the proliferation and apoptosis of chondrocytes,degradation of extracellular matrix,and inflammatory reaction.Quercetin can stably bind to the active pockets of core target proteins,thereby exerting the effect against KOA.

The Knee Wear Prediction of UHMWPE Tibial Insert Using VIPRO Platform

The failure mechanism was postulated as a combination of the high level of loading during normal activities and a non-conforming contact mechanism between the femoral condyles and the tibial insert. The question that arises is： could be this phenomenon evaluated quantitatively a priori, e.g., could be the failure due to delamination wear predicted？ In order to do some finite element simulations were performed to dynamically determinate the contact area and contact pressure for three different activities. The results obtained using VIPRO platform lead to the conclusion that many clinically reported failures of the tibial tray are caused by the adhesive and fatigue wear.

Preliminary clinical randomized controlled trial on knee osteoarthritis treated with moxibustion

Objective To observe the therapeutic effect of moxibustion on pain, stiffness and physical dysfunction caused by knee osteoarthritis （KOA）, and make an assessment on the effectiveness and safety of this therapy. Methods Fifty-nine cases of KOA were randomly divided into a moxibustion group （31 cases） and a sham-moxibustion group （28 cases）. The treatment of moxibustion was given at Nèixīyǎn （内膝眼 EX-LE 4）, Dúbí （犊鼻 ST 35） and Ashi points with real moxa cone in the moxibustion group and sham moxa cone in the sham-moxibustion group, 3 cones on each point per time, once every two days, 3 times per week for consecutively 6 weeks. The results were recorded in week 3 and 6 of the treatment, and the follow-up visit was performed 6 weeks after the end of treatment. The Western Ontario and Mcmaster Universities Osteoarthritis Index （WOMAC） and the shortest walking time of 46 m were adopted to evaluate the recovery situation of joint function. The UT-325 digital thermal detector was put to use to record the temperature change in the most obvious painful points of knee joint before and after the moxibustion. Results All the scores of WOMAC in the moxibustion group were apparently decreased in week 3 and 6 of the treatment as well as the follow-up visit, separately （P〈0.05, P〈0.01, P〈0.001）. The stiffness score of follow-up visit in the sham-moxibustion group, compared before the treatment, was lowered （P〈0.05）. The scores of pain, stiffness and physical function in the moxibustion group had a greater decrease than those in the sham-moxibustion group in week 6 of treatment and the follow-up visit （P〈0.01, P〈0.05）. The shortest walking time of 46 m in the moxibustion group after 6 weeks of the treatment was apparently reduced as compared with that before treatment （P〈0.01）, but there was no apparent improvement in the sham-moxibustion group （P〉0.05）, and the between-group difference was not significant statistically （P〉0.05）. The temperature of treatment point after the moxibustion was （49.81±3.10）？℃ in the moxibustion group and （40.98±1.67）？℃ in the sham-moxibustion group, which was both increased apparently as compared with that before the treatment （P〈0.001, P〈0.01）, and more obviously in the moxibustion group （P〈0.001）. Conclusion The moxibustion, which can obviously improve the clinical symptoms of the patients with KOA, such as pain, stiffness and physical dysfunction, is safe and effective.

Effects of acupuncture and Chinese massage on the functions of knee flexors and extensors in patients with knee osteoarthritis:randomized controlled trial

Objective To observe and evaluate the clinical efficacy of acupuncture and Chinese massage on knee osteoarthritis and conduct the analysis on the functions of knee flexors and extensors in patients. Methods Eighty cases were randomly divided into an observation group and a control group, 40 cases in each one. In observation group, acupuncture combined with Chinese massage was applied. The main acupoints for acupuncture were Nèixīyǎn （内膝眼 EX-LE 4）, Hèdǐng （鹤顶 EX-LE 2）, Dúbí （犊鼻 ST 35）, etc. In Chinese massage, gun-fa （rolling）, rou-fa （kneading）, na-fa （grasping）, ca-fa （rubbing） and passive movements of joints were applied. In control group, Fenbid was administered orally. The efficacy evaluation, JOA score and the result of isokinetic testing were compared before and after treatment in two groups. Results ① The total effective rate was 90.0% （36/40） in observation group and was 87.5% （35/40） in control group, indicating equivalent efficacy between two groups （P0.05）. JOA score after treatment increased remarkably compared with that before treatment in two groups （both P0.01）. ② It was indicated in isokinetic test of two groups that peak torque （PT）, total work （TW） and average power （AP） after treatment were all improved in comparison with those before treatment （P0.05, P0.01） and the improvement after treatment in observation group was much more remarkable as compared with that in control group （all P0.05）. Conclusion Acupuncture and Chinese massage can improve significantly in the symptoms, the muscle strength of the flexors and extensors as well as motor function of the patients with knee osteoarthritis, which is superior to that achieved with Fenbid.

Warm Needling Moxibustion for Knee Osteoarthritis: A Randomized Controlled Trial

Objective: To observe the clinical effect of warm needling moxibustion for knee osteoarthritis(KOA) by a randomized controlled trial. Methods: Sixty cases with KOA were randomly divided into an observation group and a control group, 30 cases in each group. The observation group was treated by warm needling moxibustion. The control group was treated by simple acupuncture. Ten sessions made one course and the two groups were treated for two courses. The scores of knee joint pain, stiffness and knee functions before and after the treatment were observed. Results: The scores of Western Ontario and Mc Master Universities osteoarthritis index(WOMAC) on pain, stiffness and joint functions before and after treatment in both groups were statistically different(all P<0.05). The comparisons of the scores in pain, stiffness and joint function after treatment between the two groups were all statistically different(all P<0.05). The total effective rate was 93.3% in the observation group and 80.0% in the control group. The differences of the clinical effects between the two groups were statistically significant(P<0.05). Conclusion: Warm needling moxibustion can improve the clinical symptoms and functions of the patients with KOA, and is better than ordinary acupuncture in the therapeutic effect.