Chifu refers to the skin covering the areafrom the wrist joint to the elbow joint, about 1chi (1/3 meter) in length in adults.Acupuncture with filiform needle at certainpoints within Chifu area exhibits quitesatisfact...Chifu refers to the skin covering the areafrom the wrist joint to the elbow joint, about 1chi (1/3 meter) in length in adults.Acupuncture with filiform needle at certainpoints within Chifu area exhibits quitesatisfactory therapeutic results for treatment ofsprain and contusion of the four extremities.The following are some examples.展开更多
Objective The objective of this study was to clarify the potential mechanism of quercetin against knee osteoarthritis(KOA)based on network pharmacology and molecular docking.Methods The targets of quercetin were predi...Objective The objective of this study was to clarify the potential mechanism of quercetin against knee osteoarthritis(KOA)based on network pharmacology and molecular docking.Methods The targets of quercetin were predicted by PubChem and Swiss Target Prediction databases,and the targets of KOA were obtained by DisGeNET,OMIM,and GeneCards databases.Then,the targets of quercetin and KOA were intersected to find the potential targets of quercetin against KOA.The protein–protein interaction network was constructed through the STRING database,and the core targets were screened.Gene ontology(GO)functions enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed using DAVID database.The drug–target–pathway–disease network was constructed by Cytoscape software,and the molecular docking verification was performed by Vina.Results There were 49 potential targets for quercetin against KOA,including 10 core targets.GO functions enrichment analysis showed that the biological process of quercetin against KOA mainly involved the negative regulation of apoptotic process,collagen catabolic process,and extracellular matrix disassembly.KEGG pathway enrichment analysis showed that quercetin against KOA was closely related to PI3K-Akt signaling pathway,Rap 1 signaling pathway,FoxO signaling pathway,Ras signaling pathway,TNF signaling pathway,and ErbB signaling pathway.The results of molecular docking showed that the binding energies between ligand and receptors were less than−5 kcal·mol−1.Conclusions The molecular mechanism of quercetin against KOA involves many targets and pathways,which can regulate the proliferation and apoptosis of chondrocytes,degradation of extracellular matrix,and inflammatory reaction.Quercetin can stably bind to the active pockets of core target proteins,thereby exerting the effect against KOA.展开更多
Objective To observe clinical therapeutic effects of integrative acupuncture therapy on gonarthrosis. Methods One hundred and sixty cases of gonarthrosis were randomly divided into two groups （80 cases in each group...Objective To observe clinical therapeutic effects of integrative acupuncture therapy on gonarthrosis. Methods One hundred and sixty cases of gonarthrosis were randomly divided into two groups （80 cases in each group） ： an observation group treated by electroacupuncture （EA） plus massage at points and a control group treated with conventional medicine. Results In the observation group, the cured rate was 57.50%, and the effective rate was 88.75%. In the control group, the cured rate was 36.25%, and the effective rate was 73.75%. The differences between the two groups in the cured rate and the total effective rate were of significance （X^2-test, P〈0. 01, P〈0.05）. Conclusion EA combined with massage at points is definitely effective in treating gonarthrosis.展开更多
文摘Chifu refers to the skin covering the areafrom the wrist joint to the elbow joint, about 1chi (1/3 meter) in length in adults.Acupuncture with filiform needle at certainpoints within Chifu area exhibits quitesatisfactory therapeutic results for treatment ofsprain and contusion of the four extremities.The following are some examples.
基金funded by the Project of Chinese Medicine Science and Technology Development Planning in Shandong Province(2017-018)the Project of Scientific Research and Development Plan of Colleges and Universities in Shandong Province(J18KB130)the Project of the First Batch of Excellent Scientific Research and Innovation Team in Shandong University of Chinese Medicine(220316).
文摘Objective The objective of this study was to clarify the potential mechanism of quercetin against knee osteoarthritis(KOA)based on network pharmacology and molecular docking.Methods The targets of quercetin were predicted by PubChem and Swiss Target Prediction databases,and the targets of KOA were obtained by DisGeNET,OMIM,and GeneCards databases.Then,the targets of quercetin and KOA were intersected to find the potential targets of quercetin against KOA.The protein–protein interaction network was constructed through the STRING database,and the core targets were screened.Gene ontology(GO)functions enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed using DAVID database.The drug–target–pathway–disease network was constructed by Cytoscape software,and the molecular docking verification was performed by Vina.Results There were 49 potential targets for quercetin against KOA,including 10 core targets.GO functions enrichment analysis showed that the biological process of quercetin against KOA mainly involved the negative regulation of apoptotic process,collagen catabolic process,and extracellular matrix disassembly.KEGG pathway enrichment analysis showed that quercetin against KOA was closely related to PI3K-Akt signaling pathway,Rap 1 signaling pathway,FoxO signaling pathway,Ras signaling pathway,TNF signaling pathway,and ErbB signaling pathway.The results of molecular docking showed that the binding energies between ligand and receptors were less than−5 kcal·mol−1.Conclusions The molecular mechanism of quercetin against KOA involves many targets and pathways,which can regulate the proliferation and apoptosis of chondrocytes,degradation of extracellular matrix,and inflammatory reaction.Quercetin can stably bind to the active pockets of core target proteins,thereby exerting the effect against KOA.
文摘Objective To observe clinical therapeutic effects of integrative acupuncture therapy on gonarthrosis. Methods One hundred and sixty cases of gonarthrosis were randomly divided into two groups （80 cases in each group） ： an observation group treated by electroacupuncture （EA） plus massage at points and a control group treated with conventional medicine. Results In the observation group, the cured rate was 57.50%, and the effective rate was 88.75%. In the control group, the cured rate was 36.25%, and the effective rate was 73.75%. The differences between the two groups in the cured rate and the total effective rate were of significance （X^2-test, P〈0. 01, P〈0.05）. Conclusion EA combined with massage at points is definitely effective in treating gonarthrosis.
