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莫达非尼在小鼠体内的药动学-药效学联合研究 被引量:4
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作者 马张庆 洪宗元 +1 位作者 汪五三 陶芳 《药学学报》 CAS CSCD 北大核心 2012年第1期101-104,共4页
对莫达非尼(modafinil,MOD)在小鼠体内的药动学和药效学进行联合研究,以阐明其关联性,为临床合理用药提供依据。以莫达非尼120 mg.kg-1对小鼠灌胃给药,采集给药后不同时间点血浆样本,用HPLC检测血浆药物浓度,分析平均血药浓度经时变化... 对莫达非尼(modafinil,MOD)在小鼠体内的药动学和药效学进行联合研究,以阐明其关联性,为临床合理用药提供依据。以莫达非尼120 mg.kg-1对小鼠灌胃给药,采集给药后不同时间点血浆样本,用HPLC检测血浆药物浓度,分析平均血药浓度经时变化并计算药动学参数。以小鼠自主活动计数为药效学指标,观测MOD 120 mg.kg-1灌胃给药后不同时间段内小鼠自主活动量(计数)的变化,分析与血浆药物浓度变化的相关性。结果显示,MOD在小鼠体内药动学过程符合二室模型,t1/2α,t1/2β,tmax,Cmax,AUC0-∞分别为0.42 h,3.10 h,1.00 h,41.34 mg.L-1和142.22 mg.L-1.h。MOD使小鼠自主活动明显增多,持续约4 h,且与血浆药物浓度呈同步变化,二者间存在明显的相关性。 展开更多
关键词 莫达非尼 药效学 自主治动
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Women, Conflict and Politics: Assessing Margaret Ekpo's Approach to Political Emancipation and Liberation in Nigeria
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作者 Nonso N. Bisong E. E. Andrew-Essien 《Sociology Study》 2012年第4期252-260,共9页
For generations, the potential of Nigerian women to contribute effectively to national development seems to be suppressed by many factors which cut across religious, environmental and cultural constraints. Consequentl... For generations, the potential of Nigerian women to contribute effectively to national development seems to be suppressed by many factors which cut across religious, environmental and cultural constraints. Consequently, women have strongly resolved to renegotiate their relevance through the adoption and utilization of various initiatives. At the forefront, one of these initiatives early in time was Margaret Ekpo (1914-2006), a Nigerian female political activist who unilaterally began radical movements in parts of Nigeria to transform the political consciousness of the Nigerian women, and to reverse gender-related inequalities in the country. This paper sets out to evaluate her approaches to what could be described as political re-engineering. It develops a framework drawing from theories of conflict resolution and the principles of liberalism and feminism. Findings show that despite of the limited formal education and political ideologies to which she was exposed to, she was able to rise above the prevailing challenges of her time to build a firm pedestal upon which many women politicians in Nigeria have stood to launch themselves to political limelight. The study concludes that the principles of liberalism and a desire to foster the political development of Nigeria account for Margaret Ekpo's venture into the political field. 展开更多
关键词 Margaret Ekpo WOMEN CONFLICT POLITICS emancipation
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