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先进控制技术在热风炉燃烧优化控制系统中的应用 被引量:2
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作者 苏培华 《工业加热》 CAS 2021年第7期35-37,共3页
结合热风炉的实际运行情况,采用先进的燃烧优化控制技术,实现了热风炉燃烧系统的自动控制,通过动态优化算法,发现了热风炉的最佳空燃比,实现了炉内燃烧过程的优化控制。运行结果表明,该技术提高了穹顶和排气温度的控制精度,降低了燃气... 结合热风炉的实际运行情况,采用先进的燃烧优化控制技术,实现了热风炉燃烧系统的自动控制,通过动态优化算法,发现了热风炉的最佳空燃比,实现了炉内燃烧过程的优化控制。运行结果表明,该技术提高了穹顶和排气温度的控制精度,降低了燃气消耗。该控制技术可以明显提高热风炉的经济效益,具有巨大的推广价值。 展开更多
关键词 热风炉 自优化算法 软测量 先进控制技术
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一种水声通信Turbo均衡中的软迭代信道估计算法 被引量:12
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作者 唐怀东 朱敏 武岩波 《电子与信息学报》 EI CSCD 北大核心 2013年第3期677-682,共6页
Turbo均衡技术是水声相干通信克服信道多径、消除码间干扰(ISI)的有效工具。Turbo均衡实际使用时需要对时变、多径信道进行良好的估计。为了提高信道估计的效果,该文基于时变横向滤波和相位旋转信道模型,提出一种水声通信Turbo均衡中的... Turbo均衡技术是水声相干通信克服信道多径、消除码间干扰(ISI)的有效工具。Turbo均衡实际使用时需要对时变、多径信道进行良好的估计。为了提高信道估计的效果,该文基于时变横向滤波和相位旋转信道模型,提出一种水声通信Turbo均衡中的软迭代信道估计算法。该算法采用快速自优化最小均方算法得到各数据符号处的横向滤波器系数矢量并与二阶锁相环联合优化计算。通过仿真比较,该算法明显优于硬迭代信道估计算法,且相位估计性能优于其他文献中的软迭代信道估计算法。在海上试验中,水声通信距离5 km,方向近似垂直,接收阵起伏周期10 s,起伏幅度5 m左右,在此情况下进行数据采集。将该算法用于对海试数据的单通道Turbo均衡处理,实现无误码输出,验证了所提算法在软迭代信道相位估计方面的优势。 展开更多
关键词 水声通信 TURBO均衡 信道估计 快速自优化最小均方算法 锁相环
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一种用于水声相干通信的快速自适应自最佳均衡器(英文) 被引量:1
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作者 赵亮 朱敏 《声学技术》 CSCD 北大核心 2007年第6期1259-1263,共5页
多通道判决反馈均衡器(MC-DFE)是水声相干通信克服信道多径效应、消除码间干扰(ISI)的主要手段。本文提出了一种用于水声相干通信系统的分集合并自最佳自适应多通道判决反馈均衡器。该算法将快速自优化LMS分集合并(FOLMSDC)算法、快速... 多通道判决反馈均衡器(MC-DFE)是水声相干通信克服信道多径效应、消除码间干扰(ISI)的主要手段。本文提出了一种用于水声相干通信系统的分集合并自最佳自适应多通道判决反馈均衡器。该算法将快速自优化LMS分集合并(FOLMSDC)算法、快速自优化LMS(FOLMS)算法和快速自优化LMS相位补偿(FOLMSPC)算法有机地结合在一起。该算法一方面可以进一步减少运算复杂度,另一方面,由于算法中的步长因子和相位跟踪因子可以自适应地更新,因此算法可以更好地跟踪水声信道的变化,进一步提高通信系统的接收性能。仿真结果表明,本文提出的算法的性能优于现有算法。 展开更多
关键词 水声相干通信 快速自优化LMS自适应更新算法 判决反馈均衡
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BLDC电机温度退化多段Wiener过程建模 被引量:6
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作者 袁庆洋 叶建华 李晓钢 《北京航空航天大学学报》 EI CAS CSCD 北大核心 2018年第7期1514-1519,共6页
无刷直流(BLDC)电机应用广泛,其温度退化过程呈现多段性,需建立多段退化模型,而模型参数较多时,参数估计过程对初始值敏感且易陷入局部最优。首先,针对电机的加速退化数据进行研究,采用正态加权平均(Gauss滤波)的方式滤波,改进实际数据... 无刷直流(BLDC)电机应用广泛,其温度退化过程呈现多段性,需建立多段退化模型,而模型参数较多时,参数估计过程对初始值敏感且易陷入局部最优。首先,针对电机的加速退化数据进行研究,采用正态加权平均(Gauss滤波)的方式滤波,改进实际数据在模型参数的估计中的应用。然后,引入转换函数对Wiener模型改进,建立多段Wiener模型。其次,以极大化似然函数进行参数估计,计算时采用改进粒子群优化(PSO)算法得到估计值,对比非线性模型的残差的正态性,同时分析各模型理论寿命分布及实际该批次失效分布,确定多段模型合理性;得到的模型结果说明电机在退化过程中发生了退化机理的改变,且变换速度快。最后,以非线性模型不同时刻的寿命分布给出该应力下电机的寿命预测,这对电机的预测与健康管理(PHM)有重要意义。 展开更多
关键词 无刷直流(BLDC)电机 退化建模 多段Wiener过程 单纯形自优化粒子群优化(PSO)算法 预测与健康管理(PHM)
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Adaptive Optimal Capacity Perception and Control for Wireless Multi-Hop Networks 被引量:1
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作者 Zhao Haitao Dong Yuning +2 位作者 Liu Nanjie Zhang Hui Tian Feng 《China Communications》 SCIE CSCD 2012年第11期23-30,共8页
In wireless multimedia communications, it is extremely difficult to derive general end-to-end capacity results because of decentralized packet scheduling and the interference between communicating nodes. In this paper... In wireless multimedia communications, it is extremely difficult to derive general end-to-end capacity results because of decentralized packet scheduling and the interference between communicating nodes. In this paper, we present a state-based channel capacity perception scheme to provide statistical Quality-of-Service (QoS) guarantees under a medium or high traffic load for IEEE 802.11 wireless multi-hop networks. The proposed scheme first perceives the state of the wireless link from the MAC retransmission information and extends this information to calculate the wireless channel capacity, particularly under a saturated traffic load, on the basis of the interference among flows and the link state in the wireless multi-hop networks. Finally, the adaptive optimal control algorithm allocates a network resource and forwards the data packet by taking into consideration the channel capacity deployments in multi-terminal or multi-hop mesh networks. Extensive computer simulations demonstrate that the proposed scheme can achieve better performance in terms of packet delivery ratio and network throughput compared to the existing capacity prediction schemes. 展开更多
关键词 wireless multi-hop networks capacity perception: statistical Quality of Service (QoS) CROSS-LAYER
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A Grey Wolf Optimization-Based Tilt Tri-rotor UAV Altitude Control in Transition Mode 被引量:2
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作者 MA Yan WANG Yingxun +2 位作者 CAI Zhihao ZHAO Jiang LIU Ningjun 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2022年第2期186-200,共15页
To solve the problem of altitude control of a tilt tri-rotor unmanned aerial vehicle(UAV)in the transition mode,this study presents a grey wolf optimization(GWO)based neural network adaptive control scheme for a tilt ... To solve the problem of altitude control of a tilt tri-rotor unmanned aerial vehicle(UAV)in the transition mode,this study presents a grey wolf optimization(GWO)based neural network adaptive control scheme for a tilt trirotor UAV in the transition mode.Firstly,the nonlinear model of the tilt tri-rotor UAV is established.Secondly,the tilt tri-rotor UAV altitude controller and attitude controller are designed by a neural network adaptive control method,and the GWO algorithm is adopted to optimize the parameters of the neural network and the controllers.Thirdly,two altitude control strategies are designed in the transition mode.Finally,comparative simulations are carried out to demonstrate the effectiveness and robustness of the proposed control scheme. 展开更多
关键词 tilt tri-rotor unmanned aerial vehicle altitude control neural network adaptive control grey wolf optimization(GWO)
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Multi-modality liver image registration based on multilevel B-splines free-form deformation and L-BFGS optimal algorithm 被引量:1
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作者 宋红 李佳佳 +1 位作者 王树良 马婧婷 《Journal of Central South University》 SCIE EI CAS 2014年第1期287-292,共6页
A new coarse-to-fine strategy was proposed for nonrigid registration of computed tomography(CT) and magnetic resonance(MR) images of a liver.This hierarchical framework consisted of an affine transformation and a B-sp... A new coarse-to-fine strategy was proposed for nonrigid registration of computed tomography(CT) and magnetic resonance(MR) images of a liver.This hierarchical framework consisted of an affine transformation and a B-splines free-form deformation(FFD).The affine transformation performed a rough registration targeting the mismatch between the CT and MR images.The B-splines FFD transformation performed a finer registration by correcting local motion deformation.In the registration algorithm,the normalized mutual information(NMI) was used as similarity measure,and the limited memory Broyden-Fletcher- Goldfarb-Shannon(L-BFGS) optimization method was applied for optimization process.The algorithm was applied to the fully automated registration of liver CT and MR images in three subjects.The results demonstrate that the proposed method not only significantly improves the registration accuracy but also reduces the running time,which is effective and efficient for nonrigid registration. 展开更多
关键词 multi-modal image registration affine transformation B-splines free-form deformation (FFD) L-BFGS
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一种基于机器自学习的LTE容量规划方法 被引量:1
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作者 江洪峰 郑卓文 《信息通信》 2018年第1期199-200,共2页
随着业务的高速发展,对网络资源的需求也不断升高,有限的投资下,资源的投放应更加关注建网效益,更加精准的进行网络建设。因此,如何做好网络质量与网络效益之间的平衡,做好基于网络效益的无线网精确规划成为首要任务。文章提出一种基于... 随着业务的高速发展,对网络资源的需求也不断升高,有限的投资下,资源的投放应更加关注建网效益,更加精准的进行网络建设。因此,如何做好网络质量与网络效益之间的平衡,做好基于网络效益的无线网精确规划成为首要任务。文章提出一种基于机器自学习的LTE容量规划方法,实现从传统话务预测到机器化自动识别容量需求、再到后评估的自优化闭环管理。 展开更多
关键词 LTE容量规划 机器自学习 场景化地物标签 算法自优化
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A novel adaptive mutative scale optimization algorithm based on chaos genetic method and its optimization efficiency evaluation 被引量:5
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作者 王禾军 鄂加强 邓飞其 《Journal of Central South University》 SCIE EI CAS 2012年第9期2554-2560,共7页
By combing the properties of chaos optimization method and genetic algorithm,an adaptive mutative scale chaos genetic algorithm(AMSCGA) was proposed by using one-dimensional iterative chaotic self-map with infinite co... By combing the properties of chaos optimization method and genetic algorithm,an adaptive mutative scale chaos genetic algorithm(AMSCGA) was proposed by using one-dimensional iterative chaotic self-map with infinite collapses within the finite region of [-1,1].Some measures in the optimization algorithm,such as adjusting the searching space of optimized variables continuously by using adaptive mutative scale method and making the most circle time as its control guideline,were taken to ensure its speediness and veracity in seeking the optimization process.The calculation examples about three testing functions reveal that AMSCGA has both high searching speed and high precision.Furthermore,the average truncated generations,the distribution entropy of truncated generations and the ratio of average inertia generations were used to evaluate the optimization efficiency of AMSCGA quantificationally.It is shown that the optimization efficiency of AMSCGA is higher than that of genetic algorithm. 展开更多
关键词 chaos genetic optimization algorithm CHAOS genetic algorithm optimization efficiency
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A new artificial immune algorithm and its application for optimization problems 被引量:1
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作者 于志刚 宋申民 段广仁 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2006年第2期129-133,共5页
A new artificial immune algorithm (AIA) simulating the biological immune network system with selfadjustment function is proposed in this paper. AIA is based on the modified immune network model in which two methods ... A new artificial immune algorithm (AIA) simulating the biological immune network system with selfadjustment function is proposed in this paper. AIA is based on the modified immune network model in which two methods of affinity measure evaluated are used, controlling the antibody diversity and the speed of convergence separately. The model proposed focuses on a systemic view of the immune system and takes into account cell-cell interactions denoted by antibody affinity. The antibody concentration defined in the immune network model is responsible directly for its activity in the immune system. The model introduces not only a term describing the network dynamics, but also proposes an independent term to simulate the dynamics of the antigen population. The antibodies' evolutionary processes are controlled in the algorithms by utilizing the basic properties of the immune network. Computational amount and effect is a pair of contradictions. In terms of this problem, the AIA regulating the parameters easily attains a compromise between them. At the same time, AIA can prevent premature convergence at the cost of a heavy computational amount (the iterative times). Simulation illustrates that AIA is adapted to solve optimization problems, emphasizing muhimodal optimization. 展开更多
关键词 artificial immune network optimization algorithm preventing premature convergence.
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An improved self-adaptive membrane computing optimization algorithm and its applications in residue hydrogenating model parameter estimation 被引量:1
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作者 芦会彬 薄翠梅 杨世品 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第10期3909-3915,共7页
In order to solve the non-linear and high-dimensional optimization problems more effectively, an improved self-adaptive membrane computing(ISMC) optimization algorithm was proposed. The proposed ISMC algorithm applied... In order to solve the non-linear and high-dimensional optimization problems more effectively, an improved self-adaptive membrane computing(ISMC) optimization algorithm was proposed. The proposed ISMC algorithm applied improved self-adaptive crossover and mutation formulae that can provide appropriate crossover operator and mutation operator based on different functions of the objects and the number of iterations. The performance of ISMC was tested by the benchmark functions. The simulation results for residue hydrogenating kinetics model parameter estimation show that the proposed method is superior to the traditional intelligent algorithms in terms of convergence accuracy and stability in solving the complex parameter optimization problems. 展开更多
关键词 optimization algorithm membrane computing benchmark function improved self-adaptive operator
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Real-valued multi-area self set optimization in immunity-based network intrusion detection system 被引量:1
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作者 Zhang Fengbin Xi Liang Wang Shengwen 《High Technology Letters》 EI CAS 2012年第1期1-6,共6页
The real-valued self set in immunity-based network intrusion detection system (INIDS) has some defects: multi-area and overlapping, which are ignored before. The detectors generated by this kind of self set may hav... The real-valued self set in immunity-based network intrusion detection system (INIDS) has some defects: multi-area and overlapping, which are ignored before. The detectors generated by this kind of self set may have the problem of boundary holes between self and nonself regions, and the generation efficiency is low, so that, the self set needs to be optimized before generation stage. This paper proposes a self set optimization algorithm which uses the modified clustering algorithm and Gaussian distribution theory. The clustering deals with multi-area and the Gaussian distribution deals with the overlapping. The algorithm was tested by Iris data and real network data, and the results show that the optimized self set can solve the problem of boundary holes, increase the efficiency of detector generation effectively, and improve the system's detection rate. 展开更多
关键词 immunity-based network intrusion detection system (NIDS) real-valued self set OPTIMIZATION
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Vibration mechanism analysis and algorithm optimization of contactor contact system
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作者 HUANG Kepeng WANG Fazhan +2 位作者 ZHAO Mingji GUO Baoliang OU Daquan 《Journal of Measurement Science and Instrumentation》 CAS CSCD 2021年第4期396-404,共9页
In order to solve the problem of vibration bounce caused by the contact between moving and stationary contacts in the process of switching on,two-degree-of-freedom motion differential equation of the contact system is... In order to solve the problem of vibration bounce caused by the contact between moving and stationary contacts in the process of switching on,two-degree-of-freedom motion differential equation of the contact system is established.Genetic algorithm is used to optimize the pull in process of AC contactor.The whole process of contact bounce was observed and analyzed by high-speed photography experiment.The theory and experimental results were very similar.The iron core has collided before the contact is separated,which further aggravates the contact bounce.When the iron core bounces collided again,the bounce of the contact was not affected.During the operation of the contactor,the movement of the moving iron core will cause slight vibration of the system.The contact bounce time and the maximum amplitude are reduced.The research results provide a theoretical basis for further control and reduction of contact bounce. 展开更多
关键词 electrical switch contact bounce two-degree-of-freedom motion differential equation algorithm optimization high-speed photography
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Research on Network-on-chip Dynamic and Adaptive Algorithm and Choice Strategy
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作者 Dong Li 《International Journal of Technology Management》 2013年第2期15-19,共5页
With further increase of the number of on-chip device, the bus structure has not met the requirements. In order to make better communication between each part, the chip designers need to explore a new structure to sol... With further increase of the number of on-chip device, the bus structure has not met the requirements. In order to make better communication between each part, the chip designers need to explore a new structure to solve the interconnection of on-chip device. The paper proposes a network-on-chip dynamic and adaptive algorithm which selects NoC platform with 2-dimension mesh as the carrier, incorporates communication energy consumption and delay into unified cost function and uses ant colony optimization to realize NOC map facing energy consumption and delay. The experiment indicates that compared with random map, single objective optimization can separately saves (30% - 47 %) and ( 20% - 39%) in communication energy consumption and execution time compared with random map, and joint objective optimization can further excavate the potential of time dimension in mapping scheme dominated by the energy. 展开更多
关键词 NETWORK-ON-CHIP system on chip energy consumption DELAY MAP
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Intelligent Metal Detection and Disposal Automation Equipment Based on Geometric Optimization Driving Algorithm
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作者 TIAN Xuehui LI Chengzu +3 位作者 WEI Kehan QIAN Yang ZHANG Lu WANG Rongwu 《Journal of Donghua University(English Edition)》 CAS 2024年第5期492-504,共13页
In order to solve the problem of metal impurities mixed in the production line of wood pulp nonwoven raw materials,intelligent metal detection and disposal automation equipment is designed.Based on the principle of el... In order to solve the problem of metal impurities mixed in the production line of wood pulp nonwoven raw materials,intelligent metal detection and disposal automation equipment is designed.Based on the principle of electromagnetic induction,the precise positioning of metal coordinates is realized by initial inspection and multi-directional re-inspection.Based on a geometry optimization driving algorithm,the cutting area is determined by locating the center of the circle that covers the maximum area.This approach aims to minimize the cutting area and maximize the use of materials.Additionally,the method strives to preserve as many fabrics at the edges as possible by employing the farthest edge covering circle algorithm.Based on a speed compensation algorithm,the flexible switching of upper and lower rolls is realized to ensure the maximum production efficiency.Compared with the metal detection device in the existing production line,the designed automation equipment has the advantages of higher detection sensitivity,more accurate metal coordinate positioning,smaller cutting material areas and higher production efficiency,which can make the production process more continuous,automated and intelligent. 展开更多
关键词 intelligent manufacturing electromagnetic induction metal detection geometric optimization driving algorithm automation equipment
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Optimized Ewald sum for electrostatics in molecular self-assembly systems at interfaces 被引量:1
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作者 Cong Pan Zhonghan Hu 《Science China Chemistry》 SCIE EI CAS CSCD 2015年第6期1044-1050,共7页
We extend the recent formulation of the Ewald sum for electrostatics in a two-dimensionally periodic three-dimensional multi- atom layer or two-dimensional single-atom layer system with a rectangular periodic boundary... We extend the recent formulation of the Ewald sum for electrostatics in a two-dimensionally periodic three-dimensional multi- atom layer or two-dimensional single-atom layer system with a rectangular periodic boundary condition (J Chem Theory, Comput, 2014, 10: 534-542) to that with a parallelogrammic periodic boundary condition in general. Following the discussion of an efficient implementation of the formula, we suggest a simple setup of parameters using a relatively smaller screening factor and the associated larger real space cutoff distance to reach an optimized algorithm of an order N computational cost. The connection between the previous application of the Ewald sum to ionic crystal systems and the future application to mo- lecular self-assembly or disassembly systems on solid surfaces or at liquid-liquid interfaces ate illustrated to demonstrate the applicability of the present work to simulate the self-assembly process and to produce dynamical, structural and thermody- namic properties of experimental self-assembly systems of interest. 展开更多
关键词 Ewald summation INTERFACE
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Synergistic fibroblast optimization: a novel nature-inspired computing algorithm 被引量:2
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作者 T T DHIVYAPRABHA P SUBASHINI M KRISHNAVENI 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2018年第7期815-833,共19页
The evolutionary algorithm, a subset of computational intelligence techniques, is a generic population-based stochastic optimization algorithm which uses a mechanism motivated by biological concepts. Bio-inspired comp... The evolutionary algorithm, a subset of computational intelligence techniques, is a generic population-based stochastic optimization algorithm which uses a mechanism motivated by biological concepts. Bio-inspired computing can implement successful optimization methods and adaptation approaches, which are inspired by the natural evolution and collective behavior observed in species, respectively. Although all the meta-heuristic algorithms have different inspirational sources, their objective is to find the optimum(minimum or maximum), which is problem-specific. We propose and evaluate a novel synergistic fibroblast optimization(SFO) algorithm, which exhibits the behavior of a fibroblast cellular organism in the dermal wound-healing process. Various characteristics of benchmark suites are applied to validate the robustness, reliability, generalization, and comprehensibility of SFO in diverse and complex situations. The encouraging results suggest that the collaborative and self-adaptive behaviors of fibroblasts have intellectually found the optimum solution with several different features that can improve the effectiveness of optimization strategies for solving non-linear complicated problems. 展开更多
关键词 Synergistic fibroblast optimization (SFO) Fitness analysis Convergence Benchmark suite Monk's dataset
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An enhanced hybrid and adaptive meta-model based global optimization algorithm for engineering optimization problems 被引量:4
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作者 ZHOU Guan DUAN LiBin +3 位作者 ZHAO WanZhong WANG ChunYan MA ZhengDong GU JiChao 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2016年第8期1147-1155,共9页
Due to the good balance between high efficiency and accuracy, meta-model based optimization algorithm is an important global optimization category and has been widely applied. To better solve the highly nonlinear and ... Due to the good balance between high efficiency and accuracy, meta-model based optimization algorithm is an important global optimization category and has been widely applied. To better solve the highly nonlinear and computation intensive en- gineering optimization problems, an enhanced hybrid and adaptive meta-model based global optimization (E-HAM) is first proposed in this work. Important region update method (IRU) and different sampling size strategies are proposed in the opti- mization method to enhance the performance. By applying self-moving and scaling strategy, the important region will be up- dated adaptively according to the search results to improve the resulting precision and convergence rate. Rough sampling strategy and intensive sampling strategy are applied at different stages of the optimization to improve the search efficiently and avoid results prematurely gathering in a small design space. The effectiveness of the new optimization algorithm is verified by comparing to six optimization methods with different variables bench mark optimization problems. The E-HAM optimization method is then applied to optimize the design parameters of the practical negative Poisson's ratio (NPR) crash box in this work. The results indicate that the proposed E-HAM has high accuracy and efficiency in optimizing the computation intensive prob- lems and can be widely used in engineering industry. 展开更多
关键词 global optimization META-MODELING important region update method crash box
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Graph and Hint Based Algorithm for Machining Feature Automation Recognition and Mapping
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作者 张汝珍 周雄辉 邱彦杰 《Journal of Shanghai Jiaotong university(Science)》 EI 2009年第5期574-579,共6页
Feature recognition is a process of extracting machining features which has engineering meaning from solid model, and it is a key technology of CAD/CAPP/CAM integration. This paper presents an effective and efficient ... Feature recognition is a process of extracting machining features which has engineering meaning from solid model, and it is a key technology of CAD/CAPP/CAM integration. This paper presents an effective and efficient methodology of recognizing machining feature. In this approach, features are classified into two categories: pocket feature and predefined feature. Different feature type adopts its special hint and heuristic rule, and is helpful to recognize intersection feature. Feature classification optimizes search algorithm and shortens search scope dramatically. Meanwhile, extension and split algorithm is used to handle intersecting feature. Moreover, feature mapping based on machining knowledge is introduced to support downstream application better. Finally, case studies with complex intersecting features prove that the developed approach has stronger recognizing ability. 展开更多
关键词 feature recognition intersecting feature feature mapping
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Identification of a combination of SNPs associated with Graves' disease using swarm intelligence 被引量:6
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作者 WEI Bin PENG QinKe +1 位作者 ZHANG QuanWei LI ChenYao 《Science China(Life Sciences)》 SCIE CAS 2011年第2期139-145,共7页
Graves' disease,the production of thyroid-stimulating hormone receptor-stimulating antibodies leading to hyperthyroidism,is one of the most common forms of human autoimmune disease.It is widely agreed that complex... Graves' disease,the production of thyroid-stimulating hormone receptor-stimulating antibodies leading to hyperthyroidism,is one of the most common forms of human autoimmune disease.It is widely agreed that complex diseases are not controlled simply by an individual gene or DNA variation but by their combination.Single nucleotide polymorphisms(SNPs),which are the most common form of DNA variation,have great potential as a medical diagnostic tool.In this paper,the P-value is used as a SNP pre-selection criterion,and a wrapper algorithm with binary particle swarm optimization is used to find the rule for discriminating between affected and control subjects.We analyzed the association between combinations of SNPs and Graves' disease by investigating 108 SNPs in 384 cases and 652 controls.We evaluated our method by differentiating between cases and controls in a five-fold cross validation test,and it achieved a 72.9% prediction accuracy with a combination of 17 SNPs.The experimental results showed that SNPs,even those with a high P-value,have a greater effect on Graves' disease when acting in a combination. 展开更多
关键词 Graves' disease single nucleotide polymorphism case-control study swarm intelligence
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