In order to deal with the dynamic positioning system control problems of dredgers working under strong dredging reaction or harsh environments,an adaptive backstepping method is proposed.Disturbances are estimated and...In order to deal with the dynamic positioning system control problems of dredgers working under strong dredging reaction or harsh environments,an adaptive backstepping method is proposed.Disturbances are estimated and compensated for by the adaptive method without extra sensors on dredging equipment,and the control mechanism is simplified.Adaptive control is used to compensate for the reaction and environmental disturbances on the dredger,so the dredger can maintain the desired position with a minimum error and shock.The proposed adaptive robust controller guarantees the global asymptotic stability of the closed-loop system and rapid position tracking of the dredger.The simulation results show that the proposed controller has superior performance in position tracking and robustness to large disturbances.展开更多
A recombinant inbred line (RIL) population composed of 157 lines derived from an inter-subspecific hybrid of Daguandao/IR28 by the single seed descent method was used as materials, and the quantitative trait loci (...A recombinant inbred line (RIL) population composed of 157 lines derived from an inter-subspecific hybrid of Daguandao/IR28 by the single seed descent method was used as materials, and the quantitative trait loci (QTLs) coffering the resistance to sheath blight in the 157 RILs and the parents were detected using the toothpick inoculation method. The disease indexes of rice sheath blight in the two parents and 157 RILs were scored and the QTLs responsible for rice sheath blight resistance were detected accordingly by QTL Cartographer software. The results showed that a total of 4 QTLs (qsbl, qsb2, qsb5-1, qsb5-2) conferring sheath blight resistance were detected on chromosomes 1, 2 and 5, and their variance explained ranged from 10.41% to 36.92%. The additive effect of qsb5-1 was negative, indicat- ing that the QTLs derived from donor parent IR 28 could enhance the resistance to sheath blight. However, the additive effects of qsbl, qsb2 and qsb5-2 were positive, indicating that the QTLs derived from donor parent Daguandao weakened the resis- tance to sheath blight.展开更多
Self-diffraction appears when the strong laser goes through two-dimensional material suspension,and this spatial self-phase modulation(SPPM)phenomenon can be used to measure nonlinear optical parameters and achieve op...Self-diffraction appears when the strong laser goes through two-dimensional material suspension,and this spatial self-phase modulation(SPPM)phenomenon can be used to measure nonlinear optical parameters and achieve optical switch.At present,the mechanism of SPPM is still ambiguous.The debate mainly focuses on whether the phenomenon is caused by the nonlinear refractive index of the two-dimensional material or the thermal effect of the laser.The lack of theory limits the dimension of the phase modulation to the radius of the diffraction ring and the vertical imbalance.Therefore,it is urgent to establish a unified and universal SSPM theoretical system of two-dimensional material.展开更多
In the light of C-mapping method and topological current theory, the stability of disclinations around a spherical particle in nematic liquid crystals is studied. We consider two different defect structures around a s...In the light of C-mapping method and topological current theory, the stability of disclinations around a spherical particle in nematic liquid crystals is studied. We consider two different defect structures around a spherical particle: disclination ring and point defect at the north or south pole of the particle. We calculate the free energy of these different defects in the elastic theory. It is pointed out that the total Frank free energy density can be divided into two parts. One is the distorted energy density of director field around the disclinations. The other is the free energy density of disclinations themselves, which is shown to be concentrated at the defect and to be topologically quantized in the unit of (k - k24)π/2. It is shown that in the presence of saddle-splay elasticity a dipole (radial and hyperbolic hedgehog) configuration that accompanies a particle with strong homeotropic anchoring takes the structure of a small disclination ring, not a point defect.展开更多
Mg−Al layered double hydroxides(LDHs),produced on cast Mg−xCa(x=0.5,0.8,2.0,wt.%)alloys by an in-situ growth method,showed good corrosion resistance compared to the bare magnesium substrate.The influence mechanism of ...Mg−Al layered double hydroxides(LDHs),produced on cast Mg−xCa(x=0.5,0.8,2.0,wt.%)alloys by an in-situ growth method,showed good corrosion resistance compared to the bare magnesium substrate.The influence mechanism of the second phase(Mg_(2)Ca)on LDHs production was investigated.Increasing Ca content increased the amount of Mg_(2)Ca,decreasing the grain size and the corrosion rate of the alloys.The increased amount of the second phase particles and the grain refinement promoted the growth of LDHs,and thus led to the decreasing of corrosion rate of the Mg−xCa alloys with LDHs.A higher Mg_(2)Ca amount resulted in forming fluffy LDHs.Due to the dual effects of the second phase(Mg_(2)Ca)for LDHs growth and microgalvanic corrosion,LDHs/Mg−0.8Ca showed the lowest corrosion rate.展开更多
The proceeding of cancer development seems to be driven by the complex interaction among cells, stroma and adjacent tissue. Here we advocate a new conception, cancer field, to describe the development of cancer, a com...The proceeding of cancer development seems to be driven by the complex interaction among cells, stroma and adjacent tissue. Here we advocate a new conception, cancer field, to describe the development of cancer, a complex adaptive system. Cancer field may be divided into center of tumor, periphery of tumor and adjacent tissue. The balance of inhibitors and inducers, including the interaction among cancer cells, niche and adjacent tissue, governs the switch of development of cancer field, which mimic embryonic development, a dynamic process of self-organization. The radial component of intra-tumor heterogeneity raises the field change effects in cancer field. Research strategy may be changed from single cancer cell to cancer field, from malignant transform to cancer development biology.展开更多
Slip of a composite box beam may reduce its stiffness, enlarge its deformation and affect its performance. In this work, the governing differential equations and boundary conditions of composite box beams were establi...Slip of a composite box beam may reduce its stiffness, enlarge its deformation and affect its performance. In this work, the governing differential equations and boundary conditions of composite box beams were established. Analytic solutions of combined differential equations were also established. Partial degree of freedom was adopted to establish a new FEA element of three-dimensional beam, taking into account the slip effect. Slip and its first-order derivative were introduced into the nodes of composite box beams as generalized degree of freedom. Stiffness matrix and load array of beam elements were established. A three-dimensional nonlinear calculation program was worked out. The results show that the element is reliable and easy to divide and is suitable for special nonlinear analysis of large-span composite box beams.展开更多
The effect of Zn addition on the microstructure, tensile properties and electrochemical properties of as-annealed 3003 Al alloy was investigated through TEM observations, tensile tests and Tafel polarization analysis....The effect of Zn addition on the microstructure, tensile properties and electrochemical properties of as-annealed 3003 Al alloy was investigated through TEM observations, tensile tests and Tafel polarization analysis. High density precipitates are observed in the Zn-containing alloys and the alloy with 1.8% Zn addition also has rod-like precipitates. Tensile test results indicate that Zn has a great effect on tensile strength of 3003 Al alloy. The alloy with 1.5% Zn addition has the highest ultimate tensile strength. The electrochemical results indicate that Zn addition to 3003 Al alloy also has great impact on the corrosion potential of the 3003 A1 alloy in 0.5% NaCl solution and ethylene glycol-water solution. The corrosion potential varies with the Zn content and shifts negatively.展开更多
Near 50 years history of the development of radioisotope neutron sources in China is briefly reviewed.The structure design,preparing technology and production status of routine neutron sources including 210Po-Be sourc...Near 50 years history of the development of radioisotope neutron sources in China is briefly reviewed.The structure design,preparing technology and production status of routine neutron sources including 210Po-Be sources,210Po mock fission sources,241Am-Be sources,238Pu-Be sources,252Cf spontaneous fission sources and other special-shape neutron sources are summarized.In addition,the prospects of development on radioisotope neutron source in China are predicted from the needs of nuclear power construction,oil well-logging,neutron moisture gauge and neutron brachytherapy.展开更多
Heteroatom-doped carbon has been demonstrated to be one of the most promising non-noble metal catalysts with high catalytic activity and stability through the modification of the electronic and geometric structures.In...Heteroatom-doped carbon has been demonstrated to be one of the most promising non-noble metal catalysts with high catalytic activity and stability through the modification of the electronic and geometric structures.In this study,we develop a novel solvent method to prepare interconnected N,S co-doped three-dimensional(3D)carbon networks with tunable nanopores derived from an asso-ciated complex based on melamine and sodium dodecylbenzene sulfonate(SDBS).After the intro-duction of silica templates and calcination,the catalyst exhibits 3D networks with interconnected 50-nm pores and partial graphitization.With the increase of the number of Lewis base sites caused by the N doping and change of the carbon charge and spin densities caused by the S doping,the designed N,S co-doped catalyst exhibits a similar electrochemical activity to that of the commercial 20-wt%Pt/C as an oxygen reduction reaction catalyst.In addition,in an aluminum-air battery,the proposed catalyst even outperforms the commercial 5-wt%Pt/C catalyst.Both interconnected porous structures and synergistic effects of N and S contribute to the superior catalytic perfor-mance.This study paves the way for the synthesis of various other N-doped and co-doped carbon materials as efficient catalysts in electrochemical energy applications.展开更多
In the present paper, initial-boundary value problem of plane stress state of micropolar theory of elasticity is considered for orthotropic material in the domain of thin rectangle. General hypotheses are formulated, ...In the present paper, initial-boundary value problem of plane stress state of micropolar theory of elasticity is considered for orthotropic material in the domain of thin rectangle. General hypotheses are formulated, which are the qualitative results of the asymptotic method of integration of the stated initial-boundary value problem. On the basis of the accepted hypotheses general applied one-dimensional models of dynamics of bending deformation of micropolar orthotropic elastic thin bars with free fields of displacements and rotations are constructed with and without consideration of shear deformations. With the help of the constructed models different dynamic problems of micropolar bars can be studied. Here concrete problems of free and forced vibrations of hinged supported micropolar orthotropic elastic thin bar are studied. Numerical analysis is done and specific features of dynamic characteristics of micropolar material are revealed. Particularly, it is shown that there is a frequency of vibrations of the micropolar bar that does not depend on bar sizes.展开更多
Objective:To observe the anti-inflammatory effect,as well as the effect on the expression of microtubule-associated protein light chain 3B(LC3B)and Beclin-1 of herbal cake-partitioned moxibustion in rats with experime...Objective:To observe the anti-inflammatory effect,as well as the effect on the expression of microtubule-associated protein light chain 3B(LC3B)and Beclin-1 of herbal cake-partitioned moxibustion in rats with experimental autoimmune thyroiditis(EAT).Methods:Female Sprague-Dawley rats were randomly divided into a normal group and a modeling group.The EAT rat model was prepared by a combination of antigen immunization plus iodine agent induction.After the model was prepared,rats in the modeling group were randomly and equally divided into a model group and a herbal cake-partitioned moxibustion group.In the herbal cake-partitioned moxibustion group,moxibustion was alternately applied to two groups of points[Dazhui(GV14)-Mingmen(GV4)and Tiantu(CV22)-Guanyuan(CV4)],and the treatment continued for 30 d.Rats in the normal and model groups were only fixed identically without intervention.Histopathological manifestations of thyroid glands were observed by hematoxylin-eosin staining;the concentrations of thyroid peroxidase antibodies(TPOAb),thyroglobulin antibodies(TGAb),interleukin-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)were detected by enzyme-linked immunosorbent assay;real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry were used to detect the mRNA and protein expression of autophagy-related factors LC3B and Beclin-1 in thyroid tissue.Results:There were massive follicular destruction,lymphocytic infiltration,and interstitial fibrous tissue hyperplasia of the thyroid glands in the model group.Some follicles of the thyroid glands were destroyed with few lymphocyte infiltrations and fibrous tissue hyperplasia in the moxibustion group.Compared with the normal group,the concentrations of serum TPOAb,TGAb,IL-1β,IL-6,and TNF-αwere increased in the model rats(P<0.05);the mRNA and protein expression levels of LC3B and Beclin-1 in thyroid tissue were reduced in the model group(P<0.05).Compared with the model group,the concentrations of serum TPOAb,TGAb,IL-1β,IL-6,and TNF-αwere reduced in the herbal cake-partitioned moxibustion group(P<0.05);the mRNA and protein expression levels of LC3B and Beclin-1 in thyroid tissue were increased in the herbal cake-partitioned moxibustion group(P<0.05).The mRNA and protein expression of LC3B and Beclin-1 in thyroid tissue was negatively correlated with the serum levels of TPOAb and TGAb.Conclusion:Herbal cake-partitioned moxibustion reduces the inflammatory response in the thyroid glands of EAT rats and lowers the levels of serum TPOAb and TGAb.This may be related to the regulation of mRNA and protein expression of the autophagy-associated factors LC3B and Beclin-1 in rat thyroid tissue.展开更多
Objective To observe the sexual differences in electrophysiological properties of neurons in the robust nucleus of the arcopallium (RA) in adult zebra finches, and to provide the direct electrophysiological evidence...Objective To observe the sexual differences in electrophysiological properties of neurons in the robust nucleus of the arcopallium (RA) in adult zebra finches, and to provide the direct electrophysiological evidence for the sexual dimorphism of birdsong. Methods Whole-cell recording was used to record the spontaneous action potential firing rates from RA projection neurons in acute brain slices. Results The projection neurons of RA in male birds fired spontaneously at 10 Hz or above, while in female birds, the frequency was significantly lower, and even no firings could be detected. Conclusion There is a sexual difference in electrophysiological properties of projection neurons in RA, which may result from the difference in the levels of steroid hormones in birds.展开更多
Based on the principle of virtual equivalent gain,the evolution of self-similar pulses in a normal dispersion-decreasing fiber is investigated.The occurrence of wave breaking during the process under highly nonlinear ...Based on the principle of virtual equivalent gain,the evolution of self-similar pulses in a normal dispersion-decreasing fiber is investigated.The occurrence of wave breaking during the process under highly nonlinear conditions and the effect of its revealed four-wave mixing on the process are also analyzed.The results indicate that the pulse spectrum broadeningin the initial stage is dominated by self-phase modulation while by four-wave mixing in the later stage.The more intense nonlinearity is,the faster the pulse evolution converges to the self-similarity synchronously in both the time domain and the spectrum domain.展开更多
Noble and active gases are released from geological samples during gas extraction for noble gas isotope analyses. The active gases should be removed before inletting to mass spectrometers for the analyses. The normal ...Noble and active gases are released from geological samples during gas extraction for noble gas isotope analyses. The active gases should be removed before inletting to mass spectrometers for the analyses. The normal noble gas preparation systems can clean up most geological samples. However, authigenic minerals from sedimentary rocks in oil/gas fields contain organic matter, which cannot be cleaned up by the normal preparation systems and thus influence the noble gas analyses. We introduce a novel gas purification system (PRC patent No. ZL201320117751.2), which includes several reversible purification pumps with different absorbing and degassing temperatures. It can well clean up water steam, carbon dioxide and organic gas- es. Mica minerals are often used for 40Ar/39Ar dating. A muscovite sample (2082MS) which could not be cleaned up by the normal preparation system with two SAES NP10 getters, becomes the test sample for a comparative experiment in this study. The experiment is assigned into 4 sections with the organic gas removal system (OGRS) "Closed/Opened" in turn. When the OGRS is closed only with two NP10 getters for purification, the 40At intensities increase in curves with inlet time because of impurities, the 40Ar/39Ar dating results yield age errors about +2%-±1% (20-). When the OGRS is opened for purification, in contrast, the 40Ar intensities decrease linearly with inlet time. This indicates that the gases have been cleaned up effectively, and the 40Ar/39Ar results yield ages with errors in ±0.4%. The OGRS is very helpful to obtain high-quality analysis data.展开更多
基金The National Basic Research Program of China (973 Program) (No. 2005CB221505)Open Fund of Provincial Open Laboratory for Control Engineering Key Disciplines (No. KG2009-02)
文摘In order to deal with the dynamic positioning system control problems of dredgers working under strong dredging reaction or harsh environments,an adaptive backstepping method is proposed.Disturbances are estimated and compensated for by the adaptive method without extra sensors on dredging equipment,and the control mechanism is simplified.Adaptive control is used to compensate for the reaction and environmental disturbances on the dredger,so the dredger can maintain the desired position with a minimum error and shock.The proposed adaptive robust controller guarantees the global asymptotic stability of the closed-loop system and rapid position tracking of the dredger.The simulation results show that the proposed controller has superior performance in position tracking and robustness to large disturbances.
基金Supported by Jiangsu Province Science and Technology Support Program,China(BE2012307)Jiangsu Agricultural Science and Technology Innovation Fund[CX(12)1003-3]National High Technology Research and Development Program of China(863Program)(2011AA10A10)~~
文摘A recombinant inbred line (RIL) population composed of 157 lines derived from an inter-subspecific hybrid of Daguandao/IR28 by the single seed descent method was used as materials, and the quantitative trait loci (QTLs) coffering the resistance to sheath blight in the 157 RILs and the parents were detected using the toothpick inoculation method. The disease indexes of rice sheath blight in the two parents and 157 RILs were scored and the QTLs responsible for rice sheath blight resistance were detected accordingly by QTL Cartographer software. The results showed that a total of 4 QTLs (qsbl, qsb2, qsb5-1, qsb5-2) conferring sheath blight resistance were detected on chromosomes 1, 2 and 5, and their variance explained ranged from 10.41% to 36.92%. The additive effect of qsb5-1 was negative, indicat- ing that the QTLs derived from donor parent IR 28 could enhance the resistance to sheath blight. However, the additive effects of qsbl, qsb2 and qsb5-2 were positive, indicating that the QTLs derived from donor parent Daguandao weakened the resis- tance to sheath blight.
基金Project(6187031976)supported by the National Natural Science Foundation of China
文摘Self-diffraction appears when the strong laser goes through two-dimensional material suspension,and this spatial self-phase modulation(SPPM)phenomenon can be used to measure nonlinear optical parameters and achieve optical switch.At present,the mechanism of SPPM is still ambiguous.The debate mainly focuses on whether the phenomenon is caused by the nonlinear refractive index of the two-dimensional material or the thermal effect of the laser.The lack of theory limits the dimension of the phase modulation to the radius of the diffraction ring and the vertical imbalance.Therefore,it is urgent to establish a unified and universal SSPM theoretical system of two-dimensional material.
基金The project supported by the Natural Science Foundation of Shanghai Municipal Commission of Science and Technology under Grant No. 04ZR14059, National Natural Science Foundation of China under Grant No. 10447125, and the Shanghai Municipal Science and Technology Commission under Grant No. 04dz05905
文摘In the light of C-mapping method and topological current theory, the stability of disclinations around a spherical particle in nematic liquid crystals is studied. We consider two different defect structures around a spherical particle: disclination ring and point defect at the north or south pole of the particle. We calculate the free energy of these different defects in the elastic theory. It is pointed out that the total Frank free energy density can be divided into two parts. One is the distorted energy density of director field around the disclinations. The other is the free energy density of disclinations themselves, which is shown to be concentrated at the defect and to be topologically quantized in the unit of (k - k24)π/2. It is shown that in the presence of saddle-splay elasticity a dipole (radial and hyperbolic hedgehog) configuration that accompanies a particle with strong homeotropic anchoring takes the structure of a small disclination ring, not a point defect.
基金supported by the National Natural Science Foundation of China(No.51971040)the Fundamental Research Funds for the Central Universities,China(No.2020CDJQY-A007)+1 种基金China Postdoctoral Science Foundation(Nos.2017M620410,2018T110942)the Chongqing Postdoctoral Scientific Research Foundation,China(No.Xm2017010).
文摘Mg−Al layered double hydroxides(LDHs),produced on cast Mg−xCa(x=0.5,0.8,2.0,wt.%)alloys by an in-situ growth method,showed good corrosion resistance compared to the bare magnesium substrate.The influence mechanism of the second phase(Mg_(2)Ca)on LDHs production was investigated.Increasing Ca content increased the amount of Mg_(2)Ca,decreasing the grain size and the corrosion rate of the alloys.The increased amount of the second phase particles and the grain refinement promoted the growth of LDHs,and thus led to the decreasing of corrosion rate of the Mg−xCa alloys with LDHs.A higher Mg_(2)Ca amount resulted in forming fluffy LDHs.Due to the dual effects of the second phase(Mg_(2)Ca)for LDHs growth and microgalvanic corrosion,LDHs/Mg−0.8Ca showed the lowest corrosion rate.
文摘The proceeding of cancer development seems to be driven by the complex interaction among cells, stroma and adjacent tissue. Here we advocate a new conception, cancer field, to describe the development of cancer, a complex adaptive system. Cancer field may be divided into center of tumor, periphery of tumor and adjacent tissue. The balance of inhibitors and inducers, including the interaction among cancer cells, niche and adjacent tissue, governs the switch of development of cancer field, which mimic embryonic development, a dynamic process of self-organization. The radial component of intra-tumor heterogeneity raises the field change effects in cancer field. Research strategy may be changed from single cancer cell to cancer field, from malignant transform to cancer development biology.
基金Project(50708112) supported by the National Natural Science Foundation of ChinaProject(IRT1296) supported by the Program for Changjiang Scholars and Innovative Research Team in University
文摘Slip of a composite box beam may reduce its stiffness, enlarge its deformation and affect its performance. In this work, the governing differential equations and boundary conditions of composite box beams were established. Analytic solutions of combined differential equations were also established. Partial degree of freedom was adopted to establish a new FEA element of three-dimensional beam, taking into account the slip effect. Slip and its first-order derivative were introduced into the nodes of composite box beams as generalized degree of freedom. Stiffness matrix and load array of beam elements were established. A three-dimensional nonlinear calculation program was worked out. The results show that the element is reliable and easy to divide and is suitable for special nonlinear analysis of large-span composite box beams.
文摘The effect of Zn addition on the microstructure, tensile properties and electrochemical properties of as-annealed 3003 Al alloy was investigated through TEM observations, tensile tests and Tafel polarization analysis. High density precipitates are observed in the Zn-containing alloys and the alloy with 1.8% Zn addition also has rod-like precipitates. Tensile test results indicate that Zn has a great effect on tensile strength of 3003 Al alloy. The alloy with 1.5% Zn addition has the highest ultimate tensile strength. The electrochemical results indicate that Zn addition to 3003 Al alloy also has great impact on the corrosion potential of the 3003 A1 alloy in 0.5% NaCl solution and ethylene glycol-water solution. The corrosion potential varies with the Zn content and shifts negatively.
文摘Near 50 years history of the development of radioisotope neutron sources in China is briefly reviewed.The structure design,preparing technology and production status of routine neutron sources including 210Po-Be sources,210Po mock fission sources,241Am-Be sources,238Pu-Be sources,252Cf spontaneous fission sources and other special-shape neutron sources are summarized.In addition,the prospects of development on radioisotope neutron source in China are predicted from the needs of nuclear power construction,oil well-logging,neutron moisture gauge and neutron brachytherapy.
基金supported by the National Natural Science Foundation of China (51674297)the Natural Science Foundation of Hunan Province (2016JJ2137)the Fundamental Research Funds for the Central Universities of Central South University (2015cx001)~~
文摘Heteroatom-doped carbon has been demonstrated to be one of the most promising non-noble metal catalysts with high catalytic activity and stability through the modification of the electronic and geometric structures.In this study,we develop a novel solvent method to prepare interconnected N,S co-doped three-dimensional(3D)carbon networks with tunable nanopores derived from an asso-ciated complex based on melamine and sodium dodecylbenzene sulfonate(SDBS).After the intro-duction of silica templates and calcination,the catalyst exhibits 3D networks with interconnected 50-nm pores and partial graphitization.With the increase of the number of Lewis base sites caused by the N doping and change of the carbon charge and spin densities caused by the S doping,the designed N,S co-doped catalyst exhibits a similar electrochemical activity to that of the commercial 20-wt%Pt/C as an oxygen reduction reaction catalyst.In addition,in an aluminum-air battery,the proposed catalyst even outperforms the commercial 5-wt%Pt/C catalyst.Both interconnected porous structures and synergistic effects of N and S contribute to the superior catalytic perfor-mance.This study paves the way for the synthesis of various other N-doped and co-doped carbon materials as efficient catalysts in electrochemical energy applications.
文摘In the present paper, initial-boundary value problem of plane stress state of micropolar theory of elasticity is considered for orthotropic material in the domain of thin rectangle. General hypotheses are formulated, which are the qualitative results of the asymptotic method of integration of the stated initial-boundary value problem. On the basis of the accepted hypotheses general applied one-dimensional models of dynamics of bending deformation of micropolar orthotropic elastic thin bars with free fields of displacements and rotations are constructed with and without consideration of shear deformations. With the help of the constructed models different dynamic problems of micropolar bars can be studied. Here concrete problems of free and forced vibrations of hinged supported micropolar orthotropic elastic thin bar are studied. Numerical analysis is done and specific features of dynamic characteristics of micropolar material are revealed. Particularly, it is shown that there is a frequency of vibrations of the micropolar bar that does not depend on bar sizes.
基金This work was supported by the National TCM Leading Talents Support Program-Qihuang Scholars(国家中医药领军人才支持计划-岐黄学者)National Program on Key Basic Research Project“973 Program”(国家重点基础研究发展计划“973计划项目”,No.2015CB554501)+1 种基金Projects of National Natural Science Foundation of China(国家自然科学基金项目,No.82074551,No.81704176)Youth Project from Department of Science and Education,Shanghai Health Commission(上海市卫健委科教处青年基金,No.20194Y0013).
文摘Objective:To observe the anti-inflammatory effect,as well as the effect on the expression of microtubule-associated protein light chain 3B(LC3B)and Beclin-1 of herbal cake-partitioned moxibustion in rats with experimental autoimmune thyroiditis(EAT).Methods:Female Sprague-Dawley rats were randomly divided into a normal group and a modeling group.The EAT rat model was prepared by a combination of antigen immunization plus iodine agent induction.After the model was prepared,rats in the modeling group were randomly and equally divided into a model group and a herbal cake-partitioned moxibustion group.In the herbal cake-partitioned moxibustion group,moxibustion was alternately applied to two groups of points[Dazhui(GV14)-Mingmen(GV4)and Tiantu(CV22)-Guanyuan(CV4)],and the treatment continued for 30 d.Rats in the normal and model groups were only fixed identically without intervention.Histopathological manifestations of thyroid glands were observed by hematoxylin-eosin staining;the concentrations of thyroid peroxidase antibodies(TPOAb),thyroglobulin antibodies(TGAb),interleukin-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)were detected by enzyme-linked immunosorbent assay;real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry were used to detect the mRNA and protein expression of autophagy-related factors LC3B and Beclin-1 in thyroid tissue.Results:There were massive follicular destruction,lymphocytic infiltration,and interstitial fibrous tissue hyperplasia of the thyroid glands in the model group.Some follicles of the thyroid glands were destroyed with few lymphocyte infiltrations and fibrous tissue hyperplasia in the moxibustion group.Compared with the normal group,the concentrations of serum TPOAb,TGAb,IL-1β,IL-6,and TNF-αwere increased in the model rats(P<0.05);the mRNA and protein expression levels of LC3B and Beclin-1 in thyroid tissue were reduced in the model group(P<0.05).Compared with the model group,the concentrations of serum TPOAb,TGAb,IL-1β,IL-6,and TNF-αwere reduced in the herbal cake-partitioned moxibustion group(P<0.05);the mRNA and protein expression levels of LC3B and Beclin-1 in thyroid tissue were increased in the herbal cake-partitioned moxibustion group(P<0.05).The mRNA and protein expression of LC3B and Beclin-1 in thyroid tissue was negatively correlated with the serum levels of TPOAb and TGAb.Conclusion:Herbal cake-partitioned moxibustion reduces the inflammatory response in the thyroid glands of EAT rats and lowers the levels of serum TPOAb and TGAb.This may be related to the regulation of mRNA and protein expression of the autophagy-associated factors LC3B and Beclin-1 in rat thyroid tissue.
基金supported by the National Natural Science Foundation of China (No. 30970363,30570232)the Natural Science Foundation of Guangdong Province, China (No. 05005910)
文摘Objective To observe the sexual differences in electrophysiological properties of neurons in the robust nucleus of the arcopallium (RA) in adult zebra finches, and to provide the direct electrophysiological evidence for the sexual dimorphism of birdsong. Methods Whole-cell recording was used to record the spontaneous action potential firing rates from RA projection neurons in acute brain slices. Results The projection neurons of RA in male birds fired spontaneously at 10 Hz or above, while in female birds, the frequency was significantly lower, and even no firings could be detected. Conclusion There is a sexual difference in electrophysiological properties of projection neurons in RA, which may result from the difference in the levels of steroid hormones in birds.
基金supported by the School Key Fund of South-central University for Nationalities(No.yzz05008)the Hubei Provincial Department of Education(No.Q20101613)
文摘Based on the principle of virtual equivalent gain,the evolution of self-similar pulses in a normal dispersion-decreasing fiber is investigated.The occurrence of wave breaking during the process under highly nonlinear conditions and the effect of its revealed four-wave mixing on the process are also analyzed.The results indicate that the pulse spectrum broadeningin the initial stage is dominated by self-phase modulation while by four-wave mixing in the later stage.The more intense nonlinearity is,the faster the pulse evolution converges to the self-similarity synchronously in both the time domain and the spectrum domain.
基金the National Science and Technology Major Project of China(Grant No.2011ZX05025-003-007)the 135 program of Chinese Academy of Sciences(Grant No.GIGCAS-135Y234151001)
文摘Noble and active gases are released from geological samples during gas extraction for noble gas isotope analyses. The active gases should be removed before inletting to mass spectrometers for the analyses. The normal noble gas preparation systems can clean up most geological samples. However, authigenic minerals from sedimentary rocks in oil/gas fields contain organic matter, which cannot be cleaned up by the normal preparation systems and thus influence the noble gas analyses. We introduce a novel gas purification system (PRC patent No. ZL201320117751.2), which includes several reversible purification pumps with different absorbing and degassing temperatures. It can well clean up water steam, carbon dioxide and organic gas- es. Mica minerals are often used for 40Ar/39Ar dating. A muscovite sample (2082MS) which could not be cleaned up by the normal preparation system with two SAES NP10 getters, becomes the test sample for a comparative experiment in this study. The experiment is assigned into 4 sections with the organic gas removal system (OGRS) "Closed/Opened" in turn. When the OGRS is closed only with two NP10 getters for purification, the 40At intensities increase in curves with inlet time because of impurities, the 40Ar/39Ar dating results yield age errors about +2%-±1% (20-). When the OGRS is opened for purification, in contrast, the 40Ar intensities decrease linearly with inlet time. This indicates that the gases have been cleaned up effectively, and the 40Ar/39Ar results yield ages with errors in ±0.4%. The OGRS is very helpful to obtain high-quality analysis data.