融书法教育于校园活动的实践探索

如何让书法走进校园、走进孩子的生活,让它成为学生学习生活中珍贵的记忆,成为校园文化的宝贵财富?基于这些问题,南京市中央路小学遵循'儿童自体验'理念——融书法于校园活动的实践研究,独辟新路让学生成为校园书法活动的主体,活动内容自策划、活动过程自体验、活动效能自评价,让书法这颗优秀传统文化的种子,借助校园书法活动在学生心中萌芽。

Experiment study of optimization on prediction index gases of coal spontaneous combustion

The coal of Anyuan Mine has the characteristic of easy spontaneous combustion. Conventional method is difficult to predict it. Coal samples from this mine were tested in laboratory. The data obtained from laboratory determination were initialized for the value which was defined as "K". The ratio of each index gas and value of "K", and the ratio of combination index gases and value of "K", were analyzed simultaneously. The research results show that for this coal mine, if there is carbon monoxide in the gas sample, the phenomenon of oxidation and temperature rising for coal exists in this mine; if there is C_2H_4 in the gas sample, the temperature of coal perhaps exceeds 130 °C. If the coal temperature is between 35 °C and 130 °C, prediction and forecast for coal spontaneous combustion depend on the value of Φ(CO)/K mainly; if the temperature of coal is between 130 °C and 300 °C, prediction and forecast for coal spontaneous combustion depend on the value of Φ(C_2H_6)/Φ(C_2H_2) and Φ(C_2H_6)/K. The research results provide experimental basis for the prediction of coal spontaneous combustion in Anyuan coal mine, and have better guidance on safe production of this coal mine.

Inhibition of p38 mitogen-activated protein kinase attenuates experimental autoimmune hepatitis: Involvement of nuclear factor kappa B

To investigate the role of p38 mitogen-activated protein kinase （p38MAPK） in murine experimental autoimmune hepatitis （EAH）.METHODS： To induce EAH, the syngeneic S-100 antigen emulsified in complete Freud＇s adjuvant was injected intraperitoneally into adult male C57BI/6 mice. Liver injury was assessed by serum ALT and liver histology. The expression and activity of p38 MAPK were measured by Western blot and kinase activity assays. In addition, DNA binding activities of nuclear factor kappa B （NF-KB） were analyzed by electrophoretic mobility shift assay. The effects of SB203580, a specific p38 MAPK inhibitor, on liver injuries and expression of proinflammatory cytokines （interferon-y, IL-12, IL-1β and TNF-α） were observed.RESULTS： The activity of p38 MAPK and NF-~：B was increased and reached its peak 14 or 21 d after the first syngeneic S-100 administration. Inhibition of p38 MAPK activation by SB203580 decreased the activation of NF-~：B and the expression of proinflammatory cytokines. Moreover, hepatic injuries were improved significantly after SB203580 administration.

Three-dimensional Ordered Silica Colloidal Film Self-assembly Deposited on a VerticalSubstrate

A method for preparation of particle crystal film constructed from monodisperse silica colloidal particles in diameter of about 300 nm is reported. The films were prepared from an ethanol suspension by vertical deposition that relies on capillary forces to assemble colloidal crystal particles on a vertical substrate. The 3D ordered films were characterized by transmission spectra and scanning electric microscope (SEM). The effect of evaporation temperature, particle concentration and sintered temperature on the quality of colloidal particle crystal film was investigated.

Field Performance Analysis of Shoes Used in the Takraw Games in Malaysia

Using proper footwear is crucial to avoid pain, deformations and injuries on foot. For athletes, a pair of good shoes is vital for comfort and may add to performance improvement. The main objective of this study is to study the performance of some commonly used shoes in the takraw games by using experimental tests and thermal measurements. The momentum and kinetic energies that were generated by the takraw shoes were also measured. The methods used in this study included free fall test, impact force analysis and surface thermal assessment. From the outcomes of the experiments, it was found that the prototype FA shoe was better in absorption of momentum and impact force than the other shoes and also with lower surface temperature after the trial game. These outcomes suggested that it was more suitable to be worn by the takraw players for better performance. All the information obtained from this study are particularly useful for improvement on the current design oftakraw shoe.

Self-dual Vortices in Schrdinger-Chern-Simons Model

By making use of the U（1） gauge potential decomposition theory and the Ф-mapping topological current theory, we investigate the Schroedinger-Chern-Simons model in the thin-film superconductor system and obtain an exact Bogomolny self-dual equation with a topological term. It is revealed that there exist self-dual vortices in the system. We study the inner topological structure of the self-dual vortices and show that their topological charges are topologically quantized and labeled by Hopf indices and Brouwer degrees. Furthermore, the vortices are found generating or annihilating at the limit points and encountering, splitting or merging at the bifurcation points of the vector field Ф.

Phage displaying peptides mimic schistosoma antigenic epitopes selected by rat natural antibodies and protective immunity induced by their immunization in mice

AIM: To obtain the short peptides mimic antigenic epitopes selected by rat natural antibodies to schistosomes, and to explore their immunoprotection against schistosomiasis in mice.METHODS: Adults worm antigens (AWA) were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and enzyme-linked transferred immunoblotting methods with normal SD rat sera (NRS). The killing effects on schistosomula with fresh and heat-inactivated sera from SD rats were observed. Then the purified IgG from sera of SD rats was used to biopan a phage random peptide library and 20 randomly selected positive clones were detected by ELISA and 2 of them were sequenced.Sixty female mice were immunized thrice with positive phage clones (0, 2nd, 4th wk). Each mouse was challenged with 40 cercariae, and all mice were killed 42 d after challenge. The worms and the liver eggs were counted. RESULTS: NRS could specifically react to the molecules of 75 000, 47 000, 34 500 and 23 000 of AWA. Sera from SD rats showed that the mortality rate of schistosomula was 76.2%, and when the sera were heat-inactivated in vitro, the mortality rate was decreased to 41.0% after being cultured for 48 h. The specific phages bound to IgG were enriched about 300-folds after three rounds of biopanning. Twenty clones were detected by ELISA, 19 of them bound to the specific IgG of rat sera. Immunization with these epitopes was carried out in mice. Compared with the control groups, the mixture of two mimic peptides could induce 34.9% (P = 0.000) worm reduction and 67.6% (P = 0.000) total liver egg reduction in mice. Two different mimic peptides could respectively induce 31.0% (P = 0.001), 14.5% (P = 0.074) worm reduction and 61.2% (P = 0.000), 35.7% (P = 0.000) total liver egg reduction. The specific antibody could be induced by immunization of the mimic peptides, and the antibody titer in immunized mice reached more than 1:6 400 as detected by ELISA.CONCLUSION: Specific peptides mimic antigenic molecules can be obtained by biopanning the phage random peptide library and a partially protective immunity against schistosome infection can be stimulated by these phage epitopes in mice.

Test Bench for Robotics and Autonomy： Overview and Test Results

In this paper, the TAS-I （Thales Alenia Space-Italy） Test Bench for Robotics and Autonomy （TBRA） is presented. It is based on a flexible and modular software architecture （Framework Engine）, in which each functional module （representing the GNC subsystems） implements a key functionality of the GNC （Guidance Navigation and Control）. Modules communicate by means of standardised interfaces designed for exchange of necessary information among the modules composing the entire system. This approach permits the interchange-ability of each subsystem without affecting the overall functionalities of the GNC system. In this paper, the TBRA system, together with the implemented functional modules will be described. Tests results will be reported and future development will be discussed.

连续的光谱

文章主要介绍广州美术学院建筑艺术设计学院中照明设计数学的内容构成、教学理念和教学成果的价值体现，试图探索一种适合艺术设计、强调设计应用的照明设计教学方法。

GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice

GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. Here we investigated the role of GPR54 in T cell and immune tolerance. GPR54 deficiency led to an enlarged thymus, an increased number of thymocytes, and altered thymic micro-architecture starting around puberty, indicating GPR54 function in T-cell development through its regulatory effect on the gonadal system. However, flow cytometry revealed a significant reduction in the peripheral regulatory T cell population and a moderate decrease in CD4 single-positive thymocytes in prepubertal Gpr54^(-/-) mice. These phenotypes were confirmed in chimeric mice with GPR54 deficient bone marrow-derived cells. In addition, we found elevated T cell activation in peripheral and thymic T cells in Gpr54^(-/-) mice. When intact mice were immunized with myelin oligodendrocyte glycoprotein, a more severe experimental autoimmune encephalomyelitis(EAE) developed in the Gpr54^(-/-) mice. Interestingly, aggravated EAE disease was also manifested in castrated and bone marrow chimeric Gpr54^(-/-) mice compared to the respective wild-type control,suggesting a defect in self-tolerance resulting from GPR54 deletion through a mechanism that bypassed sex hormones. These findings demonstrate a novel role for GPR54 in regulating self-tolerant immunity in a sex hormone independent manner.

A Comparison of the L2 Motivational Self System Between Chinese EFL and ESL Learners

This present study attempts to conduct a comparison of the tripartite model of L2 Motivational Self System in two different learning contexts, Chinese EFL and ESL learning settings. It was designed using a mixed methods approach, with a primary questionnaire instrument being supported by secondary interview data. The quantitative data was submitted to Amos version 18.0 to evaluate proposed models. It was found that L2 learning experience was the most important predictive dimension of intended learning effort for both samples. However, the roles of the other two components, the ideal L2 self and the ought-to L2 self, appeared to be unstable, which concludes that D6rnyei＇s tripartite model obtained partial support in both EFL and ESL contexts. The analysis of qualitative data offers strong evidence for the claim that the future self-guides do not necessarily result in intended effort unless some essential conditions are met.

Experimental study and analysis of a novel multi-media plate heat exchanger

The experimental study and analysis of a novel multi-media plate heat exchanger were performed in this paper.This novel multi-media plate heat exchanger was self-developed during the process of the investigation and design of the alpha magnetic spectrometer(AMS) thermal system.The plate of this kind of novel plate heat exchanger is formed by discontinuous structure wave consisting of convex sphere and concave sphere,its heat transfer performance is better than that of the BR1 chevron plate heat exchanger,and its resistance characteristics are superior to those of the normally used 60-degree plate heat exchanger.Furthermore,the mechanism analysis of heat transfer enhancement shows that the spherical wave structure can reduce the local field synergy angle,so as to improve the field synergy degree of velocity vector and temperature gradient vector.