目的分析初诊精神分裂症患者自发脑活动与认知功能的相关性。方法选取2016年1月~2018年1月武汉市汉口医院收治的初诊精神分裂症患者80例为观察组,并选取同期进行健康检查的80例健康志愿者为对照组。比较两组观察对象的BDST激活脑区计数...目的分析初诊精神分裂症患者自发脑活动与认知功能的相关性。方法选取2016年1月~2018年1月武汉市汉口医院收治的初诊精神分裂症患者80例为观察组,并选取同期进行健康检查的80例健康志愿者为对照组。比较两组观察对象的BDST激活脑区计数、体积、认知功能,分析BDST激活脑区计数和体积与患者认知功能的相关性。结果观察组与对照组患者的右侧额上回(47 vs 43)、额中回(42 vs 59)、额下(28 vs 53)、颞上回(52 vs 27)、颞中回(28 vs 16)、颞下回(38 vs 37)的BDST激活脑区计数比较差异无统计学意义(P>0.05),观察组患者的左侧额上回BDST激活脑区计数为19显著低于对照组患者的64,差异有统计学意义(P<0.05);观察组与对照组患者的左侧AFC、右侧AFC、左侧DLFC、右侧DLFC、右侧VLFC、左侧顶叶后下部、右侧顶叶后下部、左侧扣带回前上部、右侧扣带回前上部的BDST激活脑区体积比较差异无统计学意义(P>0.05);观察组患者左侧VLFC的BDST激活脑区体积为(15.54±8.92)显著低于对照组患者的(67.78±46.65),差异有统计学意义(P<0.05)。观察组患者的威斯康星卡片分类数、数字广度顺/倒背个数、词语流畅性均低于对照组患者,威斯康星持续错误数、Stroop A/B/C和连线A/B均高于对照组,差异有统计学意义(P<0.05)。左侧额上回BDST激活脑区计数与词语流畅性成绩呈现正相关趋势(r=0.033,P=0.038);左侧VLFC的BDST激活脑区体积与数字广度顺背成绩呈现正相关趋势(r=0.530,P=0.005)。结论初诊精神分裂症患者存在认知损害,左侧额上回BDST激活脑区计数和左侧VLFC的BDST激活脑区体积与患者认知功能存在相关性,说明精神分裂症的发病与自发脑活动异常相关。展开更多
[Objective] The aim was to probe into developing changes of spontaneous electrical activities of primordial hippocampus in Bufo bufo gargarizans in postembryonic phase. [Method] Microelectrode technique was used to re...[Objective] The aim was to probe into developing changes of spontaneous electrical activities of primordial hippocampus in Bufo bufo gargarizans in postembryonic phase. [Method] Microelectrode technique was used to record extracellularly spontaneous electrical activities of neurons in primordial hippocampus of B.bufo gargarizans in postembryonic phase. [Result] Single, consecutive single, burst, consecutive burst and anomalous spontaneous firing were recorded in primordial hippocampus, in which four kinds of spontaneous firings were recorded in forepart of postembryonic development except the anomalous spontaneous firing, and the burst spontaneous firing and consecutive burst spontaneous firing were predominant. The five kinds of spontaneous firings mentioned were recorded in anaphase of postembryonic development and the single and burst spontaneous firing were predominant.Following with the development of primordial hippocampus, the amplitudes of action potential of single firing and consecutive firing enhanced gradually, and it reaches the maximum in the metamorphosis phase; the differences of the frequencies of consecutive single firing and consecutive burst firing were not significant. [Conclusion] Following with the development of primordial hippocampus, the neuronal electrical activities showed diversification, the developmental degree of the primordial hippocampus in the metamorphosis phase was close to the subadult and adult.展开更多
文摘目的分析初诊精神分裂症患者自发脑活动与认知功能的相关性。方法选取2016年1月~2018年1月武汉市汉口医院收治的初诊精神分裂症患者80例为观察组,并选取同期进行健康检查的80例健康志愿者为对照组。比较两组观察对象的BDST激活脑区计数、体积、认知功能,分析BDST激活脑区计数和体积与患者认知功能的相关性。结果观察组与对照组患者的右侧额上回(47 vs 43)、额中回(42 vs 59)、额下(28 vs 53)、颞上回(52 vs 27)、颞中回(28 vs 16)、颞下回(38 vs 37)的BDST激活脑区计数比较差异无统计学意义(P>0.05),观察组患者的左侧额上回BDST激活脑区计数为19显著低于对照组患者的64,差异有统计学意义(P<0.05);观察组与对照组患者的左侧AFC、右侧AFC、左侧DLFC、右侧DLFC、右侧VLFC、左侧顶叶后下部、右侧顶叶后下部、左侧扣带回前上部、右侧扣带回前上部的BDST激活脑区体积比较差异无统计学意义(P>0.05);观察组患者左侧VLFC的BDST激活脑区体积为(15.54±8.92)显著低于对照组患者的(67.78±46.65),差异有统计学意义(P<0.05)。观察组患者的威斯康星卡片分类数、数字广度顺/倒背个数、词语流畅性均低于对照组患者,威斯康星持续错误数、Stroop A/B/C和连线A/B均高于对照组,差异有统计学意义(P<0.05)。左侧额上回BDST激活脑区计数与词语流畅性成绩呈现正相关趋势(r=0.033,P=0.038);左侧VLFC的BDST激活脑区体积与数字广度顺背成绩呈现正相关趋势(r=0.530,P=0.005)。结论初诊精神分裂症患者存在认知损害,左侧额上回BDST激活脑区计数和左侧VLFC的BDST激活脑区体积与患者认知功能存在相关性,说明精神分裂症的发病与自发脑活动异常相关。
基金Supported by grants from the Liaoning Provincial Department of Education(2011196)~~
文摘[Objective] The aim was to probe into developing changes of spontaneous electrical activities of primordial hippocampus in Bufo bufo gargarizans in postembryonic phase. [Method] Microelectrode technique was used to record extracellularly spontaneous electrical activities of neurons in primordial hippocampus of B.bufo gargarizans in postembryonic phase. [Result] Single, consecutive single, burst, consecutive burst and anomalous spontaneous firing were recorded in primordial hippocampus, in which four kinds of spontaneous firings were recorded in forepart of postembryonic development except the anomalous spontaneous firing, and the burst spontaneous firing and consecutive burst spontaneous firing were predominant. The five kinds of spontaneous firings mentioned were recorded in anaphase of postembryonic development and the single and burst spontaneous firing were predominant.Following with the development of primordial hippocampus, the amplitudes of action potential of single firing and consecutive firing enhanced gradually, and it reaches the maximum in the metamorphosis phase; the differences of the frequencies of consecutive single firing and consecutive burst firing were not significant. [Conclusion] Following with the development of primordial hippocampus, the neuronal electrical activities showed diversification, the developmental degree of the primordial hippocampus in the metamorphosis phase was close to the subadult and adult.
