目的研究溃疡性结肠炎(ulcerative colitis,UC)不同中医证型自发荧光成像(auto fluorescence imaging,AFI)内镜下荧光强度[绿/红(the ratio of green to red,G/R比值)]的特征,为UC中医辨证提供客观依据。方法收集UC患者49例,根据白光内...目的研究溃疡性结肠炎(ulcerative colitis,UC)不同中医证型自发荧光成像(auto fluorescence imaging,AFI)内镜下荧光强度[绿/红(the ratio of green to red,G/R比值)]的特征,为UC中医辨证提供客观依据。方法收集UC患者49例,根据白光内镜(white light endoscopy,WLE)黏膜形态和G/R比值对大肠湿热组(19例)、脾胃气虚组(30例)和健康对照组(21名)进行统计分析。结果脾胃气虚组和大肠湿热组G/R比值分别为(1.147±0.137)和(0.915±0.114),较健康对照组(1.227±0.137)降低,差异均有统计学意义(P<0.05,P<0.01),其中大肠湿热组G/R比值较脾胃气虚组更低(P<0.01)。大肠湿热组活动期内镜活动指数(endoscopic index,EI)以中度(11例)和重度(5例)为主;脾胃气虚组以缓解期(17例)和活动期EI轻度(7例)为主。活动期G/R比值小于缓解期(0.963vs1.220,P<0.01),且活动期EI轻、中、重度的G/R比值依次降低,分别为1.044、0.967和0.830(P<0.01)。结论 UC大肠湿热证的炎症程度高于脾胃气虚证。AFI能较好地反映UC的炎症程度。展开更多
It is well known that angiogenesis is critical in the transition from premalignant to malignant lesions.Consequently,early detection and diagnosis based on morphological changes to the microvessels are crucial.In the ...It is well known that angiogenesis is critical in the transition from premalignant to malignant lesions.Consequently,early detection and diagnosis based on morphological changes to the microvessels are crucial.In the last few years,new imaging techniques which utilize the properties of light-tissue interaction have been developed to increase early diagnosis of gastrointestinal(GI) tract neoplasia.We analyzed several "red-flag" endoscopic techniques used to enhance visualization of the vascular pattern of preneoplastic and neoplastic lesions(e.g.trimodal imaging including autofluorescence imaging,magnifying endoscopy and narrow band imaging).These new endoscopic techniques provide better visualization of mucosal microsurface structure and microvascular architecture and may enhance the diagnosis and characterization of mucosal lesions in the GI tract.In the near future,it is expected that trimodal imaging endoscopy will be practiced as a standard endoscopy technique as it is quick,safe and accurate for making a precise diagnosis of gastrointestinal pathology,with an emphasis on the diagnosis of early GI tract cancers.Further large-scale randomized controlled trials comparing these modalities in different patient subpopulations are warranted before their endorsement in the routine practice of GI endoscopy.展开更多
Over the last few years,improvements in endoscopic imaging technology have enabled identification of dysplasia and early cancer in Barrett's oesophagus.New techniques should exhibit high sensitivities and specific...Over the last few years,improvements in endoscopic imaging technology have enabled identification of dysplasia and early cancer in Barrett's oesophagus.New techniques should exhibit high sensitivities and specificities and have good interobserver agreement.They should also be affordable and easily applicable to the community gastroenterologist.Ideally,these modalities must exhibit the capability of imaging wide areas in real time whilst enabling the endoscopist to specifically target abnormal areas.This review will specifically focus on some of the novel endoscopic imaging modalities currently available in routine practice which includes chromoendoscopy,autofluorescence imaging and narrow band imaging.展开更多
文摘目的研究溃疡性结肠炎(ulcerative colitis,UC)不同中医证型自发荧光成像(auto fluorescence imaging,AFI)内镜下荧光强度[绿/红(the ratio of green to red,G/R比值)]的特征,为UC中医辨证提供客观依据。方法收集UC患者49例,根据白光内镜(white light endoscopy,WLE)黏膜形态和G/R比值对大肠湿热组(19例)、脾胃气虚组(30例)和健康对照组(21名)进行统计分析。结果脾胃气虚组和大肠湿热组G/R比值分别为(1.147±0.137)和(0.915±0.114),较健康对照组(1.227±0.137)降低,差异均有统计学意义(P<0.05,P<0.01),其中大肠湿热组G/R比值较脾胃气虚组更低(P<0.01)。大肠湿热组活动期内镜活动指数(endoscopic index,EI)以中度(11例)和重度(5例)为主;脾胃气虚组以缓解期(17例)和活动期EI轻度(7例)为主。活动期G/R比值小于缓解期(0.963vs1.220,P<0.01),且活动期EI轻、中、重度的G/R比值依次降低,分别为1.044、0.967和0.830(P<0.01)。结论 UC大肠湿热证的炎症程度高于脾胃气虚证。AFI能较好地反映UC的炎症程度。
文摘It is well known that angiogenesis is critical in the transition from premalignant to malignant lesions.Consequently,early detection and diagnosis based on morphological changes to the microvessels are crucial.In the last few years,new imaging techniques which utilize the properties of light-tissue interaction have been developed to increase early diagnosis of gastrointestinal(GI) tract neoplasia.We analyzed several "red-flag" endoscopic techniques used to enhance visualization of the vascular pattern of preneoplastic and neoplastic lesions(e.g.trimodal imaging including autofluorescence imaging,magnifying endoscopy and narrow band imaging).These new endoscopic techniques provide better visualization of mucosal microsurface structure and microvascular architecture and may enhance the diagnosis and characterization of mucosal lesions in the GI tract.In the near future,it is expected that trimodal imaging endoscopy will be practiced as a standard endoscopy technique as it is quick,safe and accurate for making a precise diagnosis of gastrointestinal pathology,with an emphasis on the diagnosis of early GI tract cancers.Further large-scale randomized controlled trials comparing these modalities in different patient subpopulations are warranted before their endorsement in the routine practice of GI endoscopy.
文摘Over the last few years,improvements in endoscopic imaging technology have enabled identification of dysplasia and early cancer in Barrett's oesophagus.New techniques should exhibit high sensitivities and specificities and have good interobserver agreement.They should also be affordable and easily applicable to the community gastroenterologist.Ideally,these modalities must exhibit the capability of imaging wide areas in real time whilst enabling the endoscopist to specifically target abnormal areas.This review will specifically focus on some of the novel endoscopic imaging modalities currently available in routine practice which includes chromoendoscopy,autofluorescence imaging and narrow band imaging.
